Browse the latest research

Interferon contributes to photosensitivity at least in part by causing Langerhans cell ADAM17 dysfunction, raising the possibility that anifrolumab ameliorates lupus skin disease in part by restoring Langerhans cell function.

A gene expression data-informed model reveals that a small fraction of interferon-producing cells can effectively constrain early virus spread in epithelial tissue, elucidating connections between critical dynamics and infection heterogeneity.

Dopaminergic and serotonergic neurons in the dorsal raphe nucleus have distinct electrical and morphological properties, which are differentially altered following dopamine and noradrenaline depletion.

Exploration of the phenotype space corresponding to the sequence space of viable SARS-CoV-2 nucleocapsid protein species reveals significant diversity of biophysical characteristics, nonlocal mutation effects, and functional constraints.

Reward and punishment learning is represented in partly overlapping regions of the brain while relying on specific intra- and inter-regional interactions.

Chronic perturbations of spiking activity trigger compensatory changes in GABAergic synaptic strength, but not compensatory changes in AMPAergic synaptic strength.

Parasite migration between mainland Tanzania and Zanzibar and ongoing transmission clusters within Zanzibar highlight the need for continued preventive measures to reduce malaria transmission in the archipelago.

A detailed physiological characterization of inputs to the motor thalamus adds nuance to the notion that information from the cerebellum and basal ganglia are segregated and provides a mechanism by which the basal ganglia can gate communication between cortical areas.

RNA polymerase III plays a crucial role in controlling virulence in response to environmental changes and provides a new molecular perspective into the development of asymptomatic malaria.