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    1. Microbiology and Infectious Disease

    The target of rapamycin signaling pathway regulates vegetative development, aflatoxin biosynthesis, and pathogenicity in Aspergillus flavus

    Guoqi Li, Xiaohong Cao ... Shihua Wang
    Exploration of the target of rapamycin pathway in Aspergillus flavus reveals critical regulatory elements influencing aflatoxin synthesis and stress tolerance, offering potential targets for antifungal strategies.
    1. Neuroscience

    Chronic activation of a negative engram induces behavioral and cellular abnormalities

    Alexandra L Jellinger, Rebecca L Suthard ... Steve Ramirez
    Repeatedly activating negative memory-bearing cells produces cellular and behavioral abnormalities.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Human DDX6 regulates translation and decay of inefficiently translated mRNAs

    Ramona Weber, Chung-Te Chang
    DDX6 triggers inefficiently translated mRNA decay by interacting with the ribosome through its FDF motif via the 5'-3' mRNA decay pathway.
    1. Neuroscience

    Clustered synapses develop in distinct dendritic domains in visual cortex before eye opening

    Alexandra H Leighton, Juliette E Cheyne, Christian Lohmann
    In vivo calcium imaging in visual cortex neurons before eye opening shows that clustered synaptic inputs develop in dendritic domains, which may be precursors of computational subunits after eye opening.
    1. Medicine

    Human HPSE2 gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome

    Filipa M Lopes, Celine Grenier ... Neil A Roberts
    Proof of concept that viral vector-mediated gene transfer improves bladder function in a preclinical model of an inherited early-onset lower urinary tract disease.
    1. Microbiology and Infectious Disease

    Bacteria are a major determinant of Orsay virus transmission and infection in Caenorhabditis elegans

    Brian G Vassallo, Noemie Scheidel ... Dennis H Kim
    Distinct members of the Caenorhabditis elegans microbiota can have widely divergent effects on Orsay virus transmission, such that associated bacteria can effectively determine host susceptibility versus resistance to viral infection.
    1. Biochemistry and Chemical Biology

    Intracellular Expression of a Fluorogenic DNA Aptamer Using Retron Eco2

    Mahesh A Vibhute, Corbin Machatzke ... Hannes Mutschler
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Statistical learning shapes pain perception and prediction independently of external cues

    Jakub Onysk, Nicholas Gregory ... Flavia Mancini
    Statistical learning shapes pain perception by allowing the brain to predict and modulate pain intensity based on temporal patterns, providing insights into pain regulation and their relevance to chronic pain.
    1. Ecology

    Adipokinetic hormone signaling mediates the enhanced fecundity of Diaphorina citri infected by ‘Candidatus Liberibacter asiaticus’

    Jiayun Li, Paul Holford ... Xiaoge Nian
    Molecular mechanism that Candidatus Liberibacter asiaticus improves the lipid metabolism and fecundity of Diaphorina citri through adipokinetic hormone and its receptor.
    1. Physics of Living Systems

    Gendered hiring and attrition on the path to parity for academic faculty

    Nicholas LaBerge, Kenneth Hunter Wapman ... Daniel B Larremore
    Achieving gender parity among U.S. tenured and tenure-track faculty will require changes to hiring, which has substantially greater impacts on faculty gender representation than gendered differences in attrition rates.