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A zebrafish Cas9 knock-in model enables lineage-specific gene disruption to uncover genetic dependencies in development and disease.

Mesolimbic dopamine ramps emerge only when overall event rates are high, thereby providing a key constraint on theories of dopamine signaling.

A newly discovered long noncoding RNA lnc-FANCI-2 suppresses RAS signaling to modulate Akt and Erk1/2 phosphorylation in high-risk HPV cervical cancer, consequently regulating HPV carcinogenesis.

Early immune pressure and co-occurring mutations drive changes in hepatitis C virus fitness and evolution, revealing key dynamics in the establishment of chronic infection.

Convolutional embedding models efficiently capture wide sequence context in antibody somatic hypermutation, avoiding exponential k-mer parameter scaling and eliminating the need for per-site modeling.

Gut dysbiosis and specific microbiota composition promoted the absorption of excess palmitic acid in the ileum, driving its accumulation in the serum.

Engineering self-amplifying RNA to intrinsically disarm the innate immune pathways it triggers enables durable, externally controlled gene expression with reduced cytotoxicity and cytokine release, eliminating the need for exogenous immunosuppressants.