Alexander L Tesmer, Paulius Viskaitis ... Denis Burdakov
Orexin neurons precisely track body movement across behavioral and metabolic states, revealing a neural mechanism that links motor activity to arousal and energy resources.
Reversible synaptic plasticity between sensory neurons and interneurons, switching between inhibitory and excitatory, underpins the neural basis of salt concentration memory-dependent preference reversal in Caenorhabditis elegans.
Enalapril combats the effects of senescence by activating the pSmad1/5/9–antioxidative gene axis, enhancing antioxidative defenses and promoting cell proliferation, thereby supporting healthy aging.
Eloise Giraud, Michael Lynn ... Jean-Philippe Thivierge
A novel software tool and ground-truth optogenetic validation is provided to automatically detect putative excitatory and inhibitory cells in neuronal recordings performed with large-scale multielectrode arrays.
It is proposed that innate immune cells are positioned to activate the naïve B cell repertoire and rational application of training stimuli could enforce this, offsetting original antigenic sin, wherein recall of ‘off-target’ B cell memory can obscure vaccine effectiveness.
Jessica Mella, Regan F Volk ... Abigail Buchwalter
The inner nuclear membrane protein emerin readily traffics through the secretory pathway via its hydrophobic transmembrane domain when tagged with C-terminal GFP.
