Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Transforming a fragile protein helix into an ultrastable scaffold via a hierarchical AI and chemistry framework

    Jun Qiu, Guojin Tang ... Peng Zheng
    A hierarchical framework integrating artificial intelligence with chemical principles enables the conversion of fragile α-helices into ultrastable protein scaffolds.
    1. Structural Biology and Molecular Biophysics

    Membrane Biology: Two binding sites are better than one

    Mackenzie K Scott, John E Burke
    The reasons why two multiprotein complexes – VPS34 complex I and VPS34 complex II – are activated by different Rab proteins are becoming clearer.
    Version of Record
    Insight
    1. Structural Biology and Molecular Biophysics

    A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution

    Saulė Špokaitė, Yohei Ohashi ... Roger L Williams
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Lenacapavir-induced Lattice Hyperstabilization is Central to HIV-1 Capsid Failure at the Nuclear Pore Complex and in the Cytoplasm

    Arpa Hudait, Ryan C Burdick ... Gregory A Voth
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    A lipoprotein partner for the Escherichia coli outer membrane protein TolC

    Jim Horne, Elise Kaplan ... Ben F Luisi
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Membrane Proteins: A missing link for efflux pumps

    Hilal Wehbi, Isabelle Broutin
    A lipoprotein called YbjP could be the answer to a puzzle about efflux pumps in gram-negative bacteria.
    Version of Record
    Insight
    1. Structural Biology and Molecular Biophysics

    Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations

    Turner P Brown, Matthieu Chavent, Wonpil Im
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    The spike tip protein of bacteriophage T4

    Yves Mattenberger, Ekaterina S Knyazhanskaya ... Dominique Belin
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Adaptor protein supersaturation drives innate immune signaling and cell fate

    Alejandro Rodriguez Gama, Tayla Miller ... Randal Halfmann
    In-cell biophysical analyses identify a sequence-encoded energy storage function of innate immune adaptor proteins that allows cells to respond quickly and decisively to pathogenic signals.
    1. Structural Biology and Molecular Biophysics

    A Structural Code for Assembly Specificity in GID/CTLH-Type E3 Ligases

    Pia Maria van gen Hassend, Hermann Schindelin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
Load more

Highlights

    1. Structural Biology and Molecular Biophysics

    Two binding sites are better than one

    Mackenzie K Scott, John E Burke
    1. Structural Biology and Molecular Biophysics

    A missing link for efflux pumps

    Hilal Wehbi, Isabelle Broutin
    1. Structural Biology and Molecular Biophysics

    Receptor Proteins: Lipids challenge ligands to control receptors

    Adam JM Wollman

Senior editors

  1. Felix Campelo
    Pompeu Fabra University, Spain
  2. Qiang Cui
    Boston University, United States
  3. Volker Dötsch
    Goethe University, Germany
  4. See more editors