Browse our latest Structural Biology and Molecular Biophysics articles

Cryo-electron microscopy structures of full-length P5CS, the proline synthesis enzyme, reveal that filamentation is crucial for the coordinated catalytic reactions between the glutamate kinase and γ-glutamyl phosphate reductase domains.

A cargo recognition α-helix was identified in Nup358, which is required for activation of a dynein-dependent transport pathway that is essential for brain development.

STIM1 regulates the contractility of blood vessels and blood pressure by organizing membrane contact sites and ion channel activity in vascular smooth muscle cells in a manner that is independent of its canonical function in store-operated Ca²⁺entry.

Cryogenic electron microscopy of the ryanodine receptor 1 at near-atomic resolution reveals a calcium-inactivated conformation and uncovers a conserved lipid-binding site.

The protein STIM1 helps to maintain membrane coupling sites in smooth muscle cells that regulate arterial contractility and blood pressure.

Flow stimulates PC-1/PC-2 clusters in the plasma membrane of endothelial cells, leading to Ca²⁺ influx, NOS, SK channel, and IK channel activation, vasodilation, and a reduction in blood pressure.

Visualization of the real-time conformational transitions of the human voltage-gated proton channel hHv1 provided novel insights into how voltage and pH gradients modify the dynamic behaviors of channel structures to control proton flow across membrane.

The X-ray crystal structure of the unusual carbon–carbon bond-forming biosynthetic enzyme CylK reveals a unique biochemical strategy for selective alkyl halide activation and substitution.

Deep mutagenesis experiments demonstrate that while cancer-causing mutations in Ras selectively alter regulatory interactions with GTPase-activating proteins, Ras is also activated by many mutations that decrease protein stability.

Advanced data analysis of molecular dynamics simulations of complex lipid membranes provides a quantitative and predictive model of the molecular features that control electroporation.