Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Computational and Systems Biology
    2. Neuroscience

    Dichotomy between extracellular signatures of active dendritic chemical synapses and gap junctions

    Richa Sirmaur, Rishikesh Narayanan
    Fundamental distinctions in the extracellular signatures of active-dendritic chemical and electrical synapses necessitate a revision of conventional interpretations of local field potentials centered on chemical synapses.
    1. Cell Biology
    2. Physics of Living Systems

    The titin N2A-MARP signalosome constrains muscle longitudinal hypertrophy in response to stretch

    Robbert van der Pijl, Jochen Gohlke ... Coen Ottenheijm
    Titin-associated muscle ankyrin repeat proteins limit stretch-induced longitudinal muscle hypertrophy and link titin mechanosensing to mTOR signaling.
    1. Genetics and Genomics
    2. Neuroscience

    Acute opioid responses are modulated by dynamic interactions of Oprm1 and Fgf12

    Paige M Lemen, Yanning Zuo ... Hao Chen
    A time-dependent genetic interaction between the µ opioid receptor and genes drives early morphine responses in mice, highlighting pathways linked to human substance use disorder.
    1. Neuroscience

    Excitatory cholecystokinin neurons in the CA3 area regulate the navigation learning and neuroplasticity

    Fengwen Huang, Abdul Baset, Stephen Temitayo Bello
    Cholecystokinin release from CA3 inputs to CA1 links local excitatory circuitry to hippocampal plasticity and spatial memory.
    1. Neuroscience

    Behavioral signatures of post-decisional attention in preferential choice

    Ariel Zylberberg, Ian Krajbich, Michael N Shadlen
    Gaze patterns during value-based choice may reflect post-decision processes rather than a direct causal influence of attention on preference formation.
    1. Medicine

    Magnesium isoglycyrrhizinate alleviates alcohol-associated liver disease through targeting HSD11B1

    Lu Xiao, Lu Li ... Jia Xiao
    MgIG directly targets HSD11B1 to alleviate alcohol-associated liver disease by suppressing the HSD11B1–SREBP2–IDI1 pathway, thereby reducing hepatic steatosis, inflammation, and apoptosis.
    1. Microbiology and Infectious Disease

    An abundant merozoite surface protein of Plasmodium falciparum modulates susceptibility to inhibitory antibodies

    Isabelle G Henshall, Jill Chmielewski ... Danny W Wilson
    Pathogens can use surface proteins to limit immune responses, and the finding that merozoite surface protein 2 has this property could help in Plasmodium falciparum malaria vaccine development.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection

    Kely Catarine Matteucci, Nathalia PS Leite ... Ricardo T Gazzinelli
    TNF-driven metabolic reprogramming enhances glucose utilization in monocytes through inducible nitric oxide synthase (iNOS) and hypoxia-inducible factor 1α (HIF-1α), promoting parasite control and host resistance during Plasmodium infection.
    1. Neuroscience

    Sensory adaptation and pupil-linked arousal support flexible evidence accumulation during perceptual decision making

    Kara D McGaughey, Joshua I Gold
    Flexible evidence accumulation in dynamic environments relies on multiple mechanisms, including context-dependent modulations of sensory adaptation and pupil-linked arousal.
    1. Computational and Systems Biology
    2. Neuroscience

    Active dendrites enable robust spiking computations despite timing jitter

    Thomas SJ Burger, Michael E Rule, Timothy O'Leary
    The brain computes rapidly and reliably using brief electrical impulses and likely exploits internal memory in nerve cells to achieve this more efficiently than existing computing hardware and neural networks.