Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Computational and Systems Biology
    2. Neuroscience

    Self-association enhances early attentional selection through automatic prioritization of socially salient signals

    Meike Scheller, Jan Tünnermann ... Jie Sui
    Self-related information automatically modulates early attentional selection into awareness through mechanisms distinct from physical salience, revealing an obligatory, individualized self-prioritization at the gateway to perception.
    1. Ecology
    2. Plant Biology

    Cardenolide toxin diversity impacts monarch butterfly growth and sequestration

    Anurag A Agrawal, Amy P Hastings, Paola Rubiano-Buitrago
    Confirming coevolutionary theory, monarch butterfly caterpillars show impaired growth and toxin sequestration when feeding on realistic cardenolide mixtures from their milkweed host plants.
    1. Neuroscience

    Distinct representational properties of cues and contexts shape fear and reversal learning

    Antoine Bouyeure, Daniel Pacheco-Estefan ... Nikolai Axmacher
    Fear updating relies on a flexible shift from generalized to item-specific, context-bound neural representations, revealing how the brain adapts to changing threat contingencies and why fear can return.
    1. Neuroscience

    The distinct role of human PIT in attention control

    Siyuan Huang, Lan Wang, Sheng He
    The human posterior inferotemporal cortex integrates endogenous and exogenous influences to form a unified attentional priority map for adaptive visual control.
    1. Neuroscience

    Sex-specific single transcript level atlas of vasopressin and its receptor (AVPR1a) in the mouse brain

    Anisa Azatovna Gumerova, Georgii Pevnev ... Vitaly Ryu
    Using RNAscope mapping provides the comprehensive, sex-specific atlas of vasopressin and its receptor gene expression across the murine brain, refining understanding of how vasopressin signaling is anatomically organized to regulate social behavior, stress responsivity, and homeostasis.
    1. Genetics and Genomics

    The impact of stability considerations on genetic fine-mapping

    Alan J Aw, Lionel Chentian Jin ... Yun S Song
    In statistical fine-mapping, signals stable across stratified subgroups can capture functionally important loci missed by covariate adjustment approaches, and prioritizing agreement between both approaches enhances functional variant discovery.
    1. Structural Biology and Molecular Biophysics

    Insights into substrate binding and utilization by hyaluronan synthase

    Zachery Stephens, Julia Karasinska, Jochen Zimmer
    Complementary biochemical and structural findings reveal molecular principles underlying substrate selectivity by a model hyaluronan synthase.
    1. Neuroscience

    Spatially targeted inhibitory rhythms differentially affect neuronal integration

    Drew B Headley, Benjamin Latimer ... Satish S Nair
    Beta and gamma inhibitory rhythms are preferentially tuned to govern synaptic integration in layer 5 pyramidal neurons by differentially modulating responses to inputs targeting distal dendritic and perisomatic compartments.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression

    Jie Lin, Yujian Wen ... Hao Zhu
    Compared with human-specific transcriptional factors, human-specific lncRNAs identified upon human lncRNAs’ orthologs in mammals have greatly evolved DNA-binding sites in archaic and modern humans in genes determining human traits.
    1. Neuroscience

    Readout and delayed transmission of initial afferent V1 activity in decisions about stimulus contrast

    Kieran S Mohr, Simon P Kelly
    Evidence is provided suggesting that aggregate neural activity at an early stage of visual processing (V1) can directly contribute to perceptual decisions in humans.