Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Ecology

    Stage-specific threats reveal the inadequacy of adult-centered conservation

    Yan-Fang Song, Yong-Le Wang ... Wei-Wei Zhou
    In complex life cycle taxa, the relationship between functional traits and threat status varies across developmental stages, making adult‑based threat predictions insufficient to reflect risks faced during other life stages.
    1. Neuroscience

    REM sleep prefrontal high-frequency oscillation chains mediate distinct cortical – hippocampal reactivation patterns compared to NREM sleep

    Justin D Shin, Michael Satchell ... Shantanu P Jadhav
    Rapid eye movement (REM) sleep organizes sparse, sequential cortical reactivation through chains of prefrontal high-frequency oscillations coupled to hippocampal theta, an inter-regional dialogue distinct from that of non-REM ripples.
    1. Neuroscience

    Preserved cerebellar functions despite structural degeneration in older adults

    Anda de Witte, Anouck Matthijs ... Jean-Jacques Orban de Xivry
    Cerebellar-dependent functions are mostly maintained or even enhanced across the lifespan, with cerebellar-mediated motor abilities remaining intact despite degeneration, in contrast to non-cerebellar measures.
    1. Developmental Biology

    Trpv4 links environmental temperature to testicular differentiation in hermaphroditic ricefield eel

    Zhi Yang, Tingting Luo ... Yuhua Sun
    Warm temperature promotes gonadal transformation of ricefield eel by inducing the expression of male pathway genes in ovaries via the Trpv4-pStat3-Kdm6b-Dmrt1 axis.
    1. Cell Biology

    Polo-like kinase phosphorylation of the orphan kinesin KIN-G negatively regulates centrin arm biogenesis in Trypanosoma brucei

    Yasuhiro Kurasawa, Qing Zhou ... Ziyin Li
    Polo-like kinase phosphorylation of the centrin arm-localized orphan kinesin KIN-G disrupts its microtubule-binding activity and inhibits centrin arm biogenesis in trypanosomes.
    1. Ecology

    Soil extracellular DNA fragments show variable degradation rates among sequences and environmental conditions

    Ting Li, Song Zhang ... Rongxiao Che
    Extracellular DNA degrades at markedly different rates across soils and sequences, substantially biasing estimates of prokaryotic abundance, diversity, and community composition.
    1. Neuroscience

    Differential locus coeruleus–hippocampus interactions during offline states

    Mingyu Yang, Oxana Eschenko
    Noradrenergic tone varies with arousal state, is inversely correlated with hippocampal ripple and sleep spindle oscillations, and differs according to ripple–spindle coupling, with potential implications for synaptic and systems consolidation.
    1. Neuroscience

    Realistic coupling enables flexible macroscopic traveling waves in the mouse cortex

    Guanhua Sun, James Hazelden ... Daniel B Forger
    Multimodal data-driven computational modeling reveals that realistic cortical connectivity can generate more macroscopic traveling waves than local or uniform connectivity in the mouse cortex.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Squidly harnesses enzyme functional hierarchy and contrastive learning to efficiently predict catalytic residues from sequence

    William JF Rieger, Mikael Bodén ... Ariane Mora
    Squidly enables efficient identification of enzyme catalytic residues by integrating functional hierarchies into a contrastive learning framework, requiring only protein sequences to produce scalable predictions across the known enzyme landscape.
    1. Cell Biology

    The insulin/IGF axis is critically important for controlling gene transcription in the podocyte

    Jenny A Hurcombe, Lusyan Dayalan ... Richard JM Coward
    Simultaneously knocking down both the insulin and IGF1 receptor in the kidney podocyte is highly detrimental, affecting spliceosome function and gene transcription.