Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Cryo-electron microscopy structure of human G-protein-coupled receptor 30 in the presence of bicarbonate ions revealed unique extracellular pockets and critical residues for bicarbonate binding and activation.
Ricardo CH del Rosario, Fenna M Krienen ... Steven A McCarroll
Sibling-derived chimerism in marmosets is found only in cells of hematopoietic origin, especially microglia and macrophages in the brain, whose proportions vary widely across individuals and brain regions.
Natalie Gonzaga-Saavedra, Eleanor A Degen ... Shelby A Blythe
Epigenomics and quantitative imaging are used to investigate the re-establishment of histone modifications associated with the Polycomb group of epigenetic regulators during the Drosophila maternal-to-zygotic transition.
Pascale Pescher, Thibaut Douché ... Gerald F Späth
Integrated multi-omics profiling provides evidence for coordinated changes across RNA turnover, translation, phosphorylation, and protein degradation during Leishmania differentiation, generating candidate therapeutic targets for leishmaniasis.
Simultaneous EEG–fMRI recordings in 107 human participants link coupled slow oscillations and sleep spindles to thalamic coordination of hippocampal–prefrontal communication during deep sleep.
Population-level analysis of dendritic spine nanostructure identifies distinct synaptic signatures of schizophrenia and autism, revealing Ecrg4 as a regulator of schizophrenia-associated spine pathology.
Corey T Callaghan, Diana E Bowler ... Thomas Merckx
Across the tree of life, urban communities are consistently characterized by many urban-avoiding species and few urban exploiters, revealing a general pattern in biodiversity responses to urbanization.
Bordetella pertussis hijacks the host innate immune protein PGLYRP1 via tracheal cytotoxin to suppress inflammation and evade killing, revealing a novel immune evasion strategy.
