Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Evolutionary Biology
    2. Genetics and Genomics

    Constraints on the G1/S transition pathway may favor selection of multicellularity as a passenger phenotype

    Tom Louis Ducrocq, Damien Laporte, Bertrand Daignan-Fornier
    A genetic analysis in yeast establishes that multicellularity can arise as a side-effect (passenger phenotype) of a completely independent fitness advantage unrelated to the benefits of group formation itself.
    1. Biochemistry and Chemical Biology

    Single-step in vitro reconstitution of the Escherichia coli ribosome mediated by two GTPase factors, EngA and ObgE

    Aya Sato, Weng Yu Lai ... Yoshihiro Shimizu
    A multi-step ribosome assembly method involving changes in ion concentration and temperature can now be carried out in a single step using the two GTPase factors, EngA and ObgE.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Enterovirus D68 2A protease causes nuclear pore complex dysfunction and independently contributes to motor neuron toxicity

    Katrina M Zinn, Mathew W McLaren ... Matthew J Elrick
    Enterovirus D68, a cause of acute flaccid myelitis, disrupts the composition and function of the nuclear pore complex primarily through its 2A protease, which is also toxic to motor neurons.
    1. Neuroscience

    Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity

    Ryo Masumura, Kyosuke Goda ... Naofumi Uesaka
    Disrupting oligodendrocytes during a narrow early-life window leaves cerebellar circuits permanently mistimed, but adult re-synchronization restores social and motor behavior.
    1. Cell Biology
    2. Neuroscience

    Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release

    Javier Emperador-Melero, Steven J Del Signore ... Avital A Rodal
    Presynaptic endocytic machinery is constitutively deployed to periactive zones, indicating independent assembly pathways for the exo- and endocytic machineries of nerve terminals.
    1. Immunology and Inflammation

    Tracheal terminal cells of Drosophila are immune privileged to maintain their Foxo-dependent structural plasticity

    Judith Bossen, Larissa Fritz ... Thomas Roeder
    Terminal tracheal cells in Drosophila evade innate immune activation, revealing a fundamental trade-off in which suppression of canonical immune signaling preserves Foxo-dependent plasticity and sustains respiratory function.
    1. Physics of Living Systems

    Quantifying intracellular mechanosensitive response upon spatially defined mechano-chemical triggering

    Elaheh Zare-Eelanjegh, Renard TM Lewis ... Tomaso Zambelli
    Cellular mechanotransmission depends on nuclear lamina composition, where A-type and B-type lamins define distinct nuclear mechanical responses, and microtubules dynamically buffer intracellular tension.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Host and antibiotic jointly select for greater virulence in Staphylococcus aureus

    Michelle Su, Kim L Hoang ... Timothy D Read
    Antibiotic resistance alters pathogen evolutionary trajectory.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Faroese whole genomes provide insight into ancestry and recent selection

    Iman Hamid, Ólavur Mortensen ... Noomi O Gregersen
    Present-day Faroese genomes reveal ancestry, bottleneck history, and signatures of selection, and offer a foundation for understanding the genetic architecture of health and disease in this North Atlantic founder population.
    1. Evolutionary Biology

    Are interphylum spiralian relationships resolvable?

    Ana Serra Silva, Maximilian J Telford
    Analyses of two independent phylogenomic datasets suggest an explosive radiation at the origin of Spiralia, with implications for understanding the group's evolutionary history.