Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Julia J van Adrichem, Rolinka J van der Loo ... Ronald E van Kesteren
Remote memories in Alzheimer’s disease are impaired through loss of inhibitory control over cortical engram neurons by hyperexcitable parvalbumin interneurons.
Cell-line experiments and in vivo functional experiments provide the evidence that CT-type peptides can act as ligands for both CTR/CLR-type and PDF-type receptors in a deuterostome.
PTBP1 loss in mature astrocytes causes unique astrocytic splicing changes, not neuronal-like, contrasting its role in other non-neuronal cells and indicating PTBP1 depletion alone is ineffective to drive adult-astrocyte-to-neuron conversion.
Andrés B Crane, Michiko O Inouye ... J Troy Littleton
Patch-seq RNA profiling defines the overall RNA editing landscape and single neuron editing rules for individual genetically defined Drosophila larval motoneurons.
Fireflies that gather in swarms synchronize their flashing with rhythmic periodicity and provide insights into a new mechanism for the emergence of synchrony and periodicity.
Rahul K Suryawanshi, Priyadarshini Jaishankar ... James S Fraser
The development of new small molecules demonstrates how pharmacologic inhibition of the coronavirus macrodomain restores innate immunity, leading to reduced viral replication and improved outcomes in severe infection.
