Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
MOTS-c, a mitochondrial-encoded microprotein, has immunological origins and functions, revealing for the first time that our immune system is encoded by both co-evolved nuclear and mitochondrial genomes.
In a mouse model of E. coli meningitis, non-myeloid TLR4 signaling is a key determinant of the inflammatory response in all leptomeningeal cells and of the increase in vascular permeability.
Angelly Vasquez-Correa, Johanna Arnet ... Ehab Abouheif
Latent developmental potential facilitates trait re-evolution with novel phenotypic patterns, adding a new perspective to understanding of the origins of novel traits in evolutionary and developmental biology.
Ali Özgür Argunşah, Tevye Jason Stachniak ... Theofanis Karayannis
Elfn1-mediated synaptic facilitation onto somatostatin-positive interneurons drives the local lateral inhibition required to functionally segregate cortical barrel and septal processing domains in mice.
Panagiotis Parthenios Sakagiannis, Anna-Maria Jürgensen, Martin Paul Nawrot
A three-layered modular architecture unifies diverse computational models of Drosophila larval behavior, enabling realistic closed-loop simulations from locomotion through chemotaxis to associative learning.
Cryo-electron microscopy structure of human G-protein-coupled receptor 30 in the presence of bicarbonate ions revealed unique extracellular pockets and critical residues for bicarbonate binding and activation.
Ricardo CH del Rosario, Fenna M Krienen ... Steven A McCarroll
Sibling-derived chimerism in marmosets is found only in cells of hematopoietic origin, especially microglia and macrophages in the brain, whose proportions vary widely across individuals and brain regions.
