Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Cell Biology

    Zasp52’s differentially expressed intrinsically disordered region confers thin filament stability at the Z-disc

    Nikolai Ho, Frieder Schöck
    The Z-disc of muscle sarcomeres is a solid aggregate stabilized by the intrinsically disordered region of the Alp/Enigma family protein Zasp52.
    1. Ecology
    2. Evolutionary Biology

    Evolution of sideways locomotion in crabs

    Junya Taniguchi, Tsubasa Inoue ... Yuuki Kawabata
    Sideways locomotion in true crabs likely originated once from a forward-moving ancestor, providing insight into how behavioral innovations shape evolutionary diversification.
    1. Cell Biology

    Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture

    Jessica Tittelmeier, Carl Alexander Sandhof ... Carmen Nussbaum-Krammer
    Restoring endolysosomal membrane fluidity limits tau seed escape, seeded aggregation, and neuronal toxicity in cell and animal models.
    1. Biochemistry and Chemical Biology

    A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins

    Daniel J Kelpsch, Liyun Zhang ... Steven A Farber
    An in vivo small-molecule drug screen in developing zebrafish larvae identifies dozens of unique chemical modulators capable of reducing atherogenic apolipoprotein B levels.
    1. Structural Biology and Molecular Biophysics

    Characterization of an early-diverging KCNE potassium-channel auxiliary subunit in the jawless vertebrate lamprey

    Go Kasuya, Kaei Ryu ... Koichi Nakajo
    A lamprey KCNE protein provides insight into the early evolution of vertebrate potassium-channel regulation.
    1. Structural Biology and Molecular Biophysics

    A membrane insertion code for intrinsically disordered proteins

    Fidha Nazreen Kunnath Muhammedkutty, Huan-Xiang Zhou
    A sequence-based method dubbed AroMIP predicts the membrane insertion propensities of aromatic-centered motifs, thereby advancing mechanistic understanding of membrane insertion and enriching the tools for studying intrinsically disordered protein (IDP)-membrane association.
    1. Neuroscience

    Adaptive behavior is guided by integrated representations of controlled and non-controlled information

    Bingfang Huang, Harrison Ritz, Jiefeng Jiang
    Controlled and non-controlled information are simultaneously encoded within an integrated representation in partially overlapping neural subspaces, and the strengths of both representations jointly predict performance.
    1. Neuroscience

    Top-down feedback in deep neural networks leads to functional differences during audiovisual integration

    Mashbayar Tugsbayar, Mingze Li ... Blake Richards
    Gain-modulating top-down feedback introduces behavioral differences between otherwise identical neural networks, particularly in a network with connectivity based on the human brain, which displays a flexible visual bias similar to that seen in humans.
    1. Structural Biology and Molecular Biophysics

    Optimising the tilt increment for in situ cryo-electron tomography

    Maarten Willem Tuijtel, Tomáš Majtner ... Martin Beck
    For in situ cryo-electron tomography, smaller tilt increments yield better-aligned tilt-series and higher-quality tomograms, with a 3° increment resulting in optimal subtomogram averaging resolution.
    1. Ecology

    Crickets evade bats via olfaction beyond acoustic cues

    Yannan Li, Wenhao Zhang ... Aiqing Lin
    Olfactory bat avoidance in crickets uncovers an overlooked sensory axis in this classic system and a functional eavesdropping strategy across phylogenetically distant predator–prey interactions.