Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Physics of Living Systems

    A unifying model of T-cell signaling protein condensates in reconstitution experiments

    Yannick Azhri Din Omar, Simou Sun ... Arup K Chakraborty
    The formation of biomolecular condensates by multivalent membrane proteins is delayed by slow crosslinking dynamics, with a variety of condensate morphologies emerging under different experimental conditions.
    1. Cell Biology

    Wound-induced syncytia outpace mononucleate neighbors during Drosophila wound repair

    James S White, Junmin Hua ... Andrea Page-McCaw
    In vivo live imaging, quantitative analysis, and computational modeling reveal that wound-induced epithelial cell fusion accelerates epithelial repair through several likely mechanisms.
    1. Neuroscience

    Retinotopic coding organizes the interaction between internally and externally oriented brain networks

    Adam Steel, Peter A Angeli, Caroline Robertson
    Internally and externally oriented brain networks are functionally coupled at a voxel scale through a common visuospatial code.
    1. Neuroscience

    Pathogenic O-GlcNAc dyshomeostasis is associated with cortical malformations and hyperactivity

    Florence Authier, Asad Jan ... Daan MF van Aalten
    A mouse model of O-GlcNAc transferase associated intellectual disability reveals brain structural and cognitive deficits providing an important platform for mechanistic and therapeutic discovery.
    1. Developmental Biology
    2. Genetics and Genomics

    PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development

    Julia Raulino Lima, Nicha Ungvijanpunya ... Jian Xu
    IR-couple NMD controls matrix transcript abundance during craniofacial morphogenesis.
    1. Ecology
    2. Plant Biology

    Asymmetric introgression and thermal advantage jointly drive climate-mediated lineage turnover in a mixed-ploidy reed

    Lele Liu, Wenyi Sheng ... Weihua Guo
    Climate warming can silently replace cold-adapted native lineages with warm-adapted ones through asymmetric introgression and physiological advantages, a process overlooked by species-level forecasts.
    1. Developmental Biology

    MATR3 is essential for oocyte growth and maturation quality through a dual molecular mechanism

    Yibing Bao, Zhenzi Zuo ... Chao Wang
    MATR3 coordinates oocyte transcription and follicular paracrine signaling to maintain normal oocyte growth and female fertility.
    1. Neuroscience

    Infants at high and low likelihood for autism show different EEG developmental trajectories in speech tracking and statistical learning

    Michel Godel, Ana Fló ... Marie Schaer
    In an auditory statistical learning experiment, infants at high likelihood for autism showed reduced neural entrainment to syllables, atypical developmental trajectories for word segmentation, and diminished novelty orientation to words.
    1. Neuroscience

    Enhanced tactile coding in rat neocortex under darkness

    Kotaro Yamashiro, Shiyori Tanaka ... Yuji Ikegaya
    Temporary darkness enhances the neural separability of tactile textures in the rat somatosensory cortex, revealing how sensory coding rapidly adapts to the absence of vision.
    1. Ecology
    2. Microbiology and Infectious Disease

    Environmental temperature is a strong driver of subspecies competition in the Drosophila microbiome

    Juan Bosco Gracia Alvira, Stefanie Migotti ... Christian Schlötterer
    Changes in abiotic factors, such as temperature, can affect the host fitness indirectly by modulating subspecies dynamics of key taxa, which are usually overlooked in microbiome research.