Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
A new analysis method to measure the propagation of different membrane currents along complex dendritic trees reveals the conditions leading to burst firing in a computational model of place cells.
Sohrab Salimian, Harrison Grier, Matthew Tyler Kaufman
Single neurons in mouse sensorimotor cortex are organized by their activity features into distinct subpopulations with area-spanning footprints whose boundaries align closely with anatomical and somatotopic borders.
Eutherian mammals living in China after the end-Cretaceous extinctions evolved larger tooth sizes first before becoming more specialized in their biting performance, mirroring a similar pattern in brain evolution.
Keratinocytes, which activate an EMT-like program in the skin, can prevent melanoma invasion, highlighting how changes in the tumor microenvironment can act as restraining forces in cancer.
Christopher Zhe Wei Lee, Farah Tasnim ... Florent Ginhoux
Co-culturing pluripotent stem cell-derived hepatocytes and macrophages establishes a physiologically relevant liver model that captures macrophage–hepatocyte interactions, significantly improves hepatocyte maturation, and enables more accurate prediction of immune-mediated drug toxicity.
Fine-scale exogenous attention within the foveola selectively enhances contrast gain at low-to-mid spatial frequencies while increasing response gain across a broad spatial frequency range.
Optical imaging and optogenetic inactivation of dorsal mouse neocortex reveal an unexpected role for retrosplenial cortex in the context-dependent transformation of whisker sensory information into licking for a water reward.
