Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    How attention simplifies mental representations for planning

    Jason da Silva Castanheira, Christina Chang He ... Stephen M Fleming
    Spatial attention controls the information people become aware of and, in turn, incorporate into simplified perceptual representations for use in multi-step planning.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Inferring variant-specific effective reproduction numbers from combined case and sequencing data

    Marlin D Figgins, Trevor Bedford
    Integrating case counts with genomic sequences quantifies real-time transmission advantages of viral variants.
    1. Genetics and Genomics

    Autosomal allelic inactivation at loci with variable replication timing and dosage sensitivity

    Michael B Heskett, Athanasios E Vouzas ... Mathew J Thayer
    Stable allele-specific epigenetic regulation creates cellular mosaicism of numerous autosomal dosage-sensitive genes involved in human neurological and developmental disorders.
    1. Immunology and Inflammation

    TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy

    Josselyn D Barahona, Liping Yang ... Wayne M Yokoyama
    Uterine natural killer (NK) cells require TGF-β to be derived from conventional NK cells and contribute to successful pregnancy.
    1. Neuroscience

    Visual working memory guides attention rhythmically in humans

    Jiachen Lu, Yaochun Cai, Xilin Zhang
    Working memory alternates between remembered items in a rhythmic theta cycle.
    1. Cell Biology

    Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia

    Qian Lyu, Qingchao Li ... Huijie Zhao
    Deficiency in any of the interdependent C2a proteins (CCDC108, MYCBPAP, and CFAP70) collapses this central pair microtubule-associated projection, disrupting vertebrate ciliary movement, and causing primary ciliary dyskinesia phenotypes in mice.
    1. Immunology and Inflammation

    Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

    Peter Georgiev, Sheila Johnson ... Arlene H Sharpe
    A comprehensive investigation of extracellular asparagine utilization highlights its role as a critical regulator of murine CD4+ T cell activation, differentiation, and function.
    1. Neuroscience

    Medial prefrontal cortex encodes but is not required to generate goal-directed actions under threat

    Muhammad S Sajid, Ji Zhou, Manuel A Castro-Alamancos
    Medial prefrontal cortex activity is not required for learning or execution of adaptive avoidance behavior, despite encoding select task features.
    1. Immunology and Inflammation
    2. Neuroscience

    Cribriform plate microenvironment assembles a suppressive myeloid network during EAE-induced neuroinflammation

    Collin Laaker, Martin Hsu ... Zsuzsanna Fabry
    Regulatory immune cells accumulate at the nose-to-brain interface during neuroinflammation, potentially dampening damaging immune responses.
    1. Structural Biology and Molecular Biophysics

    Lenacapavir-induced lattice hyperstabilization is central to HIV-1 capsid failure at the nuclear pore complex and in the cytoplasm

    Arpa Hudait, Ryan C Burdick ... Gregory A Voth
    Lenacapavir disrupts HIV-1 capsid elasticity, inducing mechanical rupture at the nuclear pore, highlighting that altering viral material properties can be a viable antiviral drug design strategy.
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