Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
A conserved kinase network links nutrient sensing to chromosome segregation and gene regulation by modulating cohesin dynamics through phosphorylation.
Max S Farnworth, Yi Peng Toh ... Stephen H Montgomery
A cognitive adaptation in Heliconius butterflies, accompanied by strikingly divergent changes in two principal insect integration centres, reveals that neural circuits can differ strongly in their propensity for evolutionary change.
Oguzhan F Baltaci, Andrea Usseglio Gaudi ... Benjamin M Hogan
Pericytes regulate cerebrovascular development, while vascular smooth muscle cells prevent hemorrhage and blood–brain barrier breakdown at vascular hotspots in juvenile and adult zebrafish.
ITCH is an important regulator of SARS-CoV-2 life cycle, coordinating ubiquitination, assembly, autophagosome-mediated secretion, and spike stability, highlighting ITCH as a promising therapeutic target for antiviral intervention.
TrASPr+BOS enables accurate prediction and design of tissue-specific RNA splicing, even for tissues not trained on, uncovering unseen regulatory elements and guiding sequence edits that reshape splicing outcomes.
Simone Daniela Rencken, Georgi Tushev ... Gilles Laurent
A chromosome-scale, annotated reference genome for the common cuttlefish Sepia officinalis clarifies its karyotype and reveals cephalopod-specific gene family expansions across neural and non-neural tissues.
Cryo-EM structures unexpectedly show that there are two binding sites for RAB5, with the VPS15 site being the most evolutionarily ancient site, which is essential for endocytic sorting.
Interaction between LFA-1 on natural killer cells and GBP-130 on infected erythrocytes enables immune recognition and killing of Plasmodium falciparum-infected red blood cells.
