Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Chromosome-driven DnaA activity oscillations, modulated by DNA-binding proteins, enable bacteria to coordinate DNA replication with biomass growth independently of transcriptional regulation.
Laura Lopez-Blanch, Cristina Rodríguez-Marin ... Manuel Irimia
A multi-level assessment of the relevance of 18 highly conserved neural zebrafish microexons showed that individual deletions of most microexons did not exhibit strong phenotypes, likely because of compensatory changes.
Genomic evidence from 15th-century Bolivian maize reveals similarity to Central Andean maize from Peru, and pre-Inca and Inca-era breeding that enhanced maize development through selection within Andean agricultural networks.
Children’s social cognitive development emerges from the dynamic interplay of neural maturation, parental caregiving, and dyadic brain-to-brain synchrony.
The identification of 20 causal plasma proteins for prostate cancer represents a critical step toward addressing the need for improved diagnostic specificity and reveals promising new targets for therapeutic intervention.
Zahra Khodadadi, Daniel Trpevski ... Jeanette Hellgren Kotaleski
Biophysically detailed modeling predicts that a biologically plausible synaptic plasticity rule, gated by calcium and dopamine, enables single neurons to solve nonlinear binding tasks by exploiting dendritic nonlinearities.
Multimodal neuroimaging explained 66% of the cognitive–mental health link in children, outperforming polygenic scores (21%), and accounted for 58% of the environmental contribution to this relationship.
Cavefish exhibit resilience to chronic sleep loss and tolerate elevated DNA damage and reduced DNA repair responses without compromising healthspan or longevity.
