Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Structural Biology and Molecular Biophysics

    Two Glu/Asp residues cooperatively mediate an early step of ATP hydrolysis in GHKL ATPases MutL and GyrB

    Kenji Fukui, Ayaka Shibuya ... Takato Yano
    A cooperative catalytic mechanism provides a revised framework for understanding ATP hydrolysis in a broad subset of GHKL ATPases.
    1. Neuroscience

    Retinal curl as a functional signal for heading estimation beyond the focus of expansion

    Kontessa I Zorpala, Joan López-Moliner
    The rotational retinal flow generated by natural gaze stabilization is not merely visual noise to be subtracted but actively shapes human heading perception.
    1. Neuroscience

    Developmental synchrony of retinal waves, apoptosis, and angiogenesis in postnatal retina

    Michael A Savage, Cori Bertram ... Evelyne Sernagor
    An interdisciplinary approach uncovers a never-before-seen multifaceted synchrony of developmental processes in the rodent retina which are driven by purinergic signalling from apoptotic retinal ganglion cells.
    1. Developmental Biology

    Cellular basis of accelerated whole-tooth regeneration

    Talha Mubeen, Haowen He ... Jeffrey T Streelman
    Tooth plucking triggers a rapid, coordinated regeneration program in cichlids, accelerating replacement more than threefold through temporally organized epithelial, mesenchymal, immune, vascular, and neural signaling.
    1. Biochemistry and Chemical Biology

    Integrated respirometry and metabolomics unveil circadian metabolic dynamics in Drosophila

    Farheen Akhtar, Dania M Malik ... Aalim Weljie
    Wild-type flies anticipate daily respiratory demands by coordinating substrate use, whereas short-sleep and clock-deficient mutants shift toward reactive fuel use and altered redox metabolism.
    1. Neuroscience

    Region-specific mechanosensation modulates Drosophila postural control behaviour

    William Roseby, Jonathan AC Menzies ... Claudio R Alonso
    Behavioural, optogenetic, and gene expression analyses demonstrate that regional mechanosensory processes instructed by Hox gene inputs are essential for postural control in Drosophila larvae linking local body features to behaviour.
    1. Microbiology and Infectious Disease

    Identifying a novel mechanism of L-leucine uptake in Mycobacterium tuberculosis using a chemical genomic approach

    Nisheeth Agarwal, Himanshu Gogoi ... Bappaditya Dey
    A well-orchestrated machinery for L-leucine uptake is functional in Mycobacterium tuberculosis, which is important for the intracellular survival of the tuberculosis (TB) pathogen.
    1. Neuroscience

    Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep

    Lin Yan, Litao Wu ... Chang Liu
    A state-dependent inhibitory dopaminergic microcircuit co-regulates sleep and long-term memory via distinct signaling cascades.
    1. Microbiology and Infectious Disease

    A novel rapid host cell entry pathway determines the intracellular fate of Staphylococcus aureus

    Marcel Rühling, Fabio Schmelz ... Martin J Fraunholz
    An acid sphingomyelinase-dependent rapid uptake pathway for the pathogen Staphylococcus aureus is linked to altered intracellular infection dynamics.
    1. Physics of Living Systems

    A unifying model of T-cell signaling protein condensates in reconstitution experiments

    Yannick Azhri Din Omar, Simou Sun ... Arup K Chakraborty
    The formation of biomolecular condensates by multivalent membrane proteins is delayed by slow crosslinking dynamics, with a variety of condensate morphologies emerging under different experimental conditions.