Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
A sequence-based method dubbed AroMIP predicts the membrane insertion propensities of aromatic-centered motifs, thereby advancing mechanistic understanding of membrane insertion and enriching the tools for studying intrinsically disordered protein (IDP)-membrane association.
Controlled and non-controlled information are simultaneously encoded within an integrated representation in partially overlapping neural subspaces, and the strengths of both representations jointly predict performance.
Gain-modulating top-down feedback introduces behavioral differences between otherwise identical neural networks, particularly in a network with connectivity based on the human brain, which displays a flexible visual bias similar to that seen in humans.
Maarten Willem Tuijtel, Tomáš Majtner ... Martin Beck
For in situ cryo-electron tomography, smaller tilt increments yield better-aligned tilt-series and higher-quality tomograms, with a 3° increment resulting in optimal subtomogram averaging resolution.
Olfactory bat avoidance in crickets uncovers an overlooked sensory axis in this classic system and a functional eavesdropping strategy across phylogenetically distant predator–prey interactions.
Zenith D Rudich, Jiaxi Guan ... Jeremy M Van Raamsdonk
Comparing gene expression across a panel of nine long-lived mutants in a single study reveals that these mutants utilize both common and unique genetic strategies to achieve long life.
Foveal attentional processing coordinates with peripheral attention to dynamically shape global attention allocation and fixation behavior during active vision.
Hélène Vantomme, Valentin Quiniou ... David Klatzmann
Sex-specific biases in thymic T cell receptor selection enrich female CD8 T cell repertoires for autoimmunity-associated self-antigens, helping explain women’s increased susceptibility to autoimmune diseases.
Magdalena Solyga, Marek Zelechowski, Georg B Keller
Visuomotor mismatch events elicit robust human prediction error responses that exceed conventional oddball mismatch negativity, enabling translation of sensorimotor prediction mechanisms from mice to humans.
