Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Septin-associated kinases functions in an adaptable regulatory network with overlapping functions to coordinate septin organization with actomyosin ring machinery to ensure robust cytokinesis in Saccharomyces cerevisiae.
Anne R Van Arsdale, Olga Meshcheryakova ... Jack Lenz
HPV-human DNA junction detection in serum cell-free DNA unambiguously identifies tumor genetic-signatures of integrated viral DNA from HPV-induced cancers and could be useful for recurrence prediction and monitoring residual disease.
At moderate densities, small mammalian herbivores can enhance livestock weight gains by suppressing toxic plants and improving both the abundance and nutritional quality of palatable forage in rangelands.
Primordial cardiomyocytes play an essential role in myocardial morphogenesis and coronary vascularization, but not in adult zebrafish heart regeneration.
A genome-wide RNA interference screen identified cellular processes that modulate the phase separation of a TDP-43 mutant, providing a framework for dissecting the link between its phase behavior and disease-associated aggregation.
Nahir Guadalupe Gazal, Maria Jose Castellanos-Montiel ... Nicolás Unsain
An actin-nucleation-dependent assembly of the axonal membrane skeleton reveals that βII-spectrin gap-and-patch patterns in human motor neurons represent an intermediate stage of cytoskeletal maturation.
Layer 6b neurons shape state-dependent brain rhythms and responses to orexin, revealing an underappreciated cortical mechanism that may help explain disrupted sleep-wake regulation in neurodevelopmental and psychiatric disorders more broadly.
Single-cell observations refute the expectation that centrosome positioning is critical for epithelial cell polarization while showing that proper positioning enhances polarization efficiency.
In complex life cycle taxa, the relationship between functional traits and threat status varies across developmental stages, making adult‑based threat predictions insufficient to reflect risks faced during other life stages.
Justin D Shin, Michael Satchell ... Shantanu P Jadhav
Rapid eye movement (REM) sleep organizes sparse, sequential cortical reactivation through chains of prefrontal high-frequency oscillations coupled to hippocampal theta, an inter-regional dialogue distinct from that of non-REM ripples.
