Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Neural computations in the foveal and peripheral visual fields during active search

    Jie Zhang, Xiaocang Zhu ... Huihui Zhou
    Foveal attentional processing coordinates with peripheral attention to dynamically shape global attention allocation and fixation behavior during active vision.
    1. Physics of Living Systems

    Viral commitment to infection depends on host metabolism

    Anastasios Marantos, Kim Sneppen ... Namiko Mitarai
    Energy-limited bacterial cells reduce phage adsorption, particularly for weakly binding viruses, revealing host physiology as a key factor in viral commitment to infection.
    1. Microbiology and Infectious Disease

    Three metabolic pathways replenishing the one-carbon pool collectively support growth and virulence of Listeria monocytogenes

    Sandra Freier, Sarah Frentzel ... Sven Halbedel
    Spontaneous reactivation of an interrupted biosynthetic gene reveals unexpected plasticity in folate-dependent one-carbon metabolism that promotes growth and virulence in the foodborne human pathogen Listeria monocytogenes.
    1. Neuroscience

    Overt visual attention modulates decision-related signals in the frontal cortex

    Blair RK Shevlin, Rachael Gwinn ... Ian Krajbich
    Brain activity in the pre-supplementary motor area and dorsolateral prefrontal cortex represents gaze-weighted accumulated evidence signals in value-based decision-making.
    1. Neuroscience

    α/β-Hydrolase domain-containing 6 (ABHD6) accelerates the desensitization and deactivation of TARP γ-2-containing AMPA receptors

    Rixu Cong, Huiran Li ... Chen Zhang
    The gating kinetics of AMPARs are regulated by ABHD6 in a TARP γ-2-dependent manner.
    1. Cell Biology
    2. Immunology and Inflammation

    MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide

    Michelle C Rice, Maria Imun ... Changhan Lee
    MOTS-c, a mitochondrial-encoded microprotein, has immunological origins and functions, revealing for the first time that our immune system is encoded by both co-evolved nuclear and mitochondrial genomes.
    1. Immunology and Inflammation

    TLR4 signaling drives tissue inflammation, Claudin-5 internalization, and vascular barrier breakdown in a mouse model of neonatal meningitis

    Philip V Seegren, Amir Rattner ... Jeremy Nathans
    In a mouse model of E. coli meningitis, non-myeloid TLR4 signaling is a key determinant of the inflammatory response in all leptomeningeal cells and of the increase in vascular permeability.
    1. Developmental Biology
    2. Evolutionary Biology

    Latent gene network expression underlies partial re-evolution of a polyphenic trait in the worker caste of ants

    Angelly Vasquez-Correa, Johanna Arnet ... Ehab Abouheif
    Latent developmental potential facilitates trait re-evolution with novel phenotypic patterns, adding a new perspective to understanding of the origins of novel traits in evolutionary and developmental biology.
    1. Neuroscience

    Economic and social modulations of innate decision-making in mice exposed to visual threats

    Zhe Li, Jiahui Wang ... Ya-tang Li
    Threat, reward, and social hierarchy jointly shape innate defensive decisions through vigilance-dependent value integration.
    1. Neuroscience

    Local inhibitory dynamics underpin temporal integration and functional segregation between barrels and septa in the mouse barrel cortex

    Ali Özgür Argunşah, Tevye Jason Stachniak ... Theofanis Karayannis
    Elfn1-mediated synaptic facilitation onto somatostatin-positive interneurons drives the local lateral inhibition required to functionally segregate cortical barrel and septal processing domains in mice.