Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
The tuft dendrites of neurons in the premotor cortex are uniquely selective for corrective actions, suggesting a specialized role in motor control and motor learning.
Marisa J Brothwell, Guoshen Cao ... Katsuhiko Funai
Metabolic dysfunction-associated steatotic liver disease is associated with reduced mitochondrial cardiolipin concentration in mice and humans, and cardiolipin deficiency was sufficient to drive steatosis and fibrosis in the liver.
Artificial intelligence and multimodal neuroimaging revealed brain state-dependent differences in the functional connectivity prediction of memory and identified the dopamine-modulated brain cognition gap as a marker of vulnerability to compromised brain function.
Laura C Bohorquez, Henrik Strahl ... Leendert Hamoen
Diffusion rate difference between MinD monomer and dimer is important for MinD protein gradient formation in B. subtilis, and not membrane affinity difference.
Hengqi Betty Zheng, Benjamin A Doran ... Leslie S Kean
Single-cell profiling of untreated pediatric Crohn’s disease identifies coordinated immune and epithelial cell states that stratify patients by disease severity and future anti-TNF response.
Jonathan Reinwald, Sarah Ghanayem ... Wolfgang Kelsch
Automated, long-term tracking reveals that social rank in male mice is a stable individual trait that persists across group changes, with chasing serving to negotiate rank among dominant individuals.
SETD6-mediated methylation of PPARγ establishes a positive feedback mechanism that enhances transcriptional activation and promotes hepatic lipid accumulation.
Sofie S Jacobsen, Allison B Morehouse ... Celia Kjaerby
Very-low-frequency heart rate variability reflects locus coeruleus activity during sleep and predicts spindle-dependent memory consolidation across mice and humans.
Envelope-carrying Ty3/gypsy LTR retrotransposons are ancient and widespread across animals, revealing deep evolutionary links between retroelements, viral fusogens, and retroviruses.
