Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Amrapali Datta, Phanindra Dewan ... Medhavi Vishwakarma
Mechanical interactions at the interface of mutant and wild-type cell populations govern tissue-specific responses to oncogenic transformation in epithelia, causing mutants to be extruded, spatially restrained, or undergo persistent expansion.
Camilla Do, Keiko Christine Salazar ... Anthony W Maresso
Targeted ecological sampling combined with a portable enrichment device rapidly yields a diverse array of bacteriophages against drug-resistant pathogens.
LRRK2 couples brain-derived neurotrophic factor (BDNF) signaling to synaptic actin remodeling, defining a novel mechanism of LRRK2 synaptic function and highlighting early, targetable pathways in Parkinson’s disease.
The genomic response of endothelial cells to hypoxia via MOA-seq transcription factor occupancy profiling identified known and novel HIF1A-associated and independent cis-regulatory elements, which defined ten distinct hypoxic kinetic clusters.
Cell-surface heparan sulfate clusters, not the generally assumed ACE2, mediate SARS-CoV-2 attachment and endocytic entry, fundamentally revising the viral entry paradigm and establishing heparan sulfate as a primary therapeutic target.
Estrogen receptor 1 (ESR1)-positive neurons in the pontine micturition center govern detrusor–sphincter coordination via three distinct spinal projections, representing a therapeutic target for detrusor–sphincter dyssynergia and associated voiding dysfunction.
Age-specific templates improve the quality of functional alignment using hyperalignment algorithms, and the improvement is consistent across age groups, validation analyses, and datasets.
Christopher Peterson, Joshua Miller ... Vitaly V Ganusov
Cooperation between individual virions of human cytomegalovirus at infecting cells leads to nonlinear scaling of cell infection probability with virion concentration.
Patrick B Jonker, Mumina Sadullozoda ... Alexander Muir
Modeling the metabolic microenvironment of pancreatic tumors leads to the identification of polyunsaturated fatty acid metabolism as a vulnerability of pancreatic cancer.
