Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Max S Farnworth, Yi Peng Toh ... Stephen H Montgomery
A cognitive adaptation in Heliconius butterflies, accompanied by strikingly divergent changes in two principal insect integration centres, reveals that neural circuits can differ strongly in their propensity for evolutionary change.
A conserved kinase network links nutrient sensing to chromosome segregation and gene regulation by modulating cohesin dynamics through phosphorylation.
Oguzhan F Baltaci, Andrea Usseglio Gaudi ... Benjamin M Hogan
Pericytes regulate cerebrovascular development, while vascular smooth muscle cells prevent hemorrhage and blood–brain barrier breakdown at vascular hotspots in juvenile and adult zebrafish.
TrASPr+BOS enables accurate prediction and design of tissue-specific RNA splicing, even for tissues not trained on, uncovering unseen regulatory elements and guiding sequence edits that reshape splicing outcomes.
ITCH is an important regulator of SARS-CoV-2 life cycle, coordinating ubiquitination, assembly, autophagosome-mediated secretion, and spike stability, highlighting ITCH as a promising therapeutic target for antiviral intervention.
Empirical substitution matrices from experimental measurements on 31,614 variants accurately predict cellular protein abundance changes using only amino-acid substitution and whether the site is buried or exposed.
Simone Daniela Rencken, Georgi Tushev ... Gilles Laurent
A chromosome-scale, annotated reference genome for the common cuttlefish Sepia officinalis clarifies its karyotype and reveals cephalopod-specific gene family expansions across neural and non-neural tissues.
Interaction between LFA-1 on natural killer cells and GBP-130 on infected erythrocytes enables immune recognition and killing of Plasmodium falciparum-infected red blood cells.
