Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Glaucoma-associated Optineurin mutations increase transcellular degradation of mitochondria in a vertebrate optic nerve

    Yaeram Jeong, Chung-ha O Davis ... Nicholas Marsh-Armstrong
    Increased transfer of axonal mitochondria to optic nerve astrocytes after expression of glaucoma-associated Optineurin variants suggest that increased transcellular degradation of axonal mitochondria may play a causative role in at least some forms of glaucoma.
    1. Neuroscience

    High cognitive violation of expectations is compromised in cerebellar ataxia

    Leonardo Daniel, Eli Vakil, William Saban
    Across three experiments, the cerebellum was found to support discrete sequential problems in higher cognition by processing expectation violations.
    1. Neuroscience

    Longitudinal awake imaging of mouse deep brain microvasculature with super-resolution ultrasound localization microscopy

    Yike Wang, Matthew R Lowerison ... Pengfei Song
    Ultrasound localization microscopy in awake mice enables high-resolution imaging of cerebral microvasculature in a natural physiological state, eliminates confounding effects of anesthetics, and supports reliable longitudinal vascular assessment across weeks.
    1. Immunology and Inflammation

    Layers of immunity: Deconstructing the Drosophila effector response

    Faustine Ryckebusch, Yao Tian ... Bruno Lemaitre
    New tools make it possible to investigate the timing and importance of different immune effectors in defense against infection.
    1. Evolutionary Biology

    Heterozygosity at a conserved candidate sex determination locus is associated with female development in the clonal raider ant (Ooceraea biroi)

    Kip D Lacy, Jina Lee ... Daniel JC Kronauer
    A complementary sex determination locus is conserved in ants and dates back to approximately 112 million years ago.
    1. Developmental Biology

    Sox9 prevents retinal degeneration and is required for limbal stem cell differentiation in the adult mouse eye

    Alicia Hurtado, Victor López-Soriano ... Francisco Javier Barrionuevo
    The Sox9 gene is necessary for maintaining vision in the mouse adult eye, acting as an essential factor for retinal and corneal function.
    1. Neuroscience

    Mixed evidence for the rhythmicity of auditory perceptual judgements in humans

    Cécile Fabio, Christoph Kayser
    Across multiple experiments, the evidence for any rhythmicity of auditory perception remains difficult to establish.
    1. Evolutionary Biology

    Convergent iridescence and divergent chemical signals in sympatric sister-species of Amazonian butterflies

    Joséphine Ledamoisel, Bruno Buatois ... Violaine Llaurens
    Ecological interactions exert contrasting evolutionary pressures on sympatric Morpho butterflies, promoting convergence in iridescence but divergence in chemical cues, illustrating how ecological interactions mediate trait evolution and sister-species coexistence.
    1. Neuroscience

    Recovery of the full in vivo firing range in post-lesion surviving DA SN neurons associated with Kv4.3-mediated pacemaker plasticity

    Lora Kovacheva, Josef Shin ... Jochen Roeper
    Dopamine midbrain neurons surviving a lesion slowly recover their in vivo firing patterns by homeostatic pacemaker acceleration mediated by Kv4.3 channel downregulation.
    1. Neuroscience

    Characterization of postsynaptic glutamate transporter functionality in the zebrafish retinal first synapse across different wavelengths

    Marco Garbelli, Stephanie Niklaus, Stephan CF Neuhauss
    Loss of the glutamate transporters EAAT5b and EAAT7 disrupts wavelength-specific visual processing and UV-dependent prey detection in zebrafish, revealing their key roles in modulating light integration and behaviorally relevant vision.