Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Region-specific mechanosensation modulates Drosophila postural control behaviour

    William Roseby, Jonathan AC Menzies ... Claudio R Alonso
    Behavioural, optogenetic, and gene expression analyses demonstrate that regional mechanosensory processes instructed by Hox gene inputs are essential for postural control in Drosophila larvae linking local body features to behaviour.
    1. Microbiology and Infectious Disease

    Identifying a novel mechanism of L-leucine uptake in Mycobacterium tuberculosis using a chemical genomic approach

    Nisheeth Agarwal, Himanshu Gogoi ... Bappaditya Dey
    A well-orchestrated machinery for L-leucine uptake is functional in Mycobacterium tuberculosis, which is important for the intracellular survival of the tuberculosis (TB) pathogen.
    1. Neuroscience

    Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep

    Lin Yan, Litao Wu ... Chang Liu
    A state-dependent inhibitory dopaminergic microcircuit co-regulates sleep and long-term memory via distinct signaling cascades.
    1. Microbiology and Infectious Disease

    A novel rapid host cell entry pathway determines the intracellular fate of Staphylococcus aureus

    Marcel Rühling, Fabio Schmelz ... Martin J Fraunholz
    An acid sphingomyelinase-dependent rapid uptake pathway for the pathogen Staphylococcus aureus is linked to altered intracellular infection dynamics.
    1. Physics of Living Systems

    A unifying model of T-cell signaling protein condensates in reconstitution experiments

    Yannick Azhri Din Omar, Simou Sun ... Arup K Chakraborty
    The formation of biomolecular condensates by multivalent membrane proteins is delayed by slow crosslinking dynamics, with a variety of condensate morphologies emerging under different experimental conditions.
    1. Cell Biology

    Wound-induced syncytia outpace mononucleate neighbors during Drosophila wound repair

    James S White, Junmin Hua ... Andrea Page-McCaw
    In vivo live imaging, quantitative analysis, and computational modeling reveal that wound-induced epithelial cell fusion accelerates epithelial repair through several likely mechanisms.
    1. Neuroscience

    Retinotopic coding organizes the interaction between internally and externally oriented brain networks

    Adam Steel, Peter A Angeli, Caroline Robertson
    Internally and externally oriented brain networks are functionally coupled at a voxel scale through a common visuospatial code.
    1. Neuroscience

    Pathogenic O-GlcNAc dyshomeostasis is associated with cortical malformations and hyperactivity

    Florence Authier, Asad Jan ... Daan MF van Aalten
    A mouse model of O-GlcNAc transferase associated intellectual disability reveals brain structural and cognitive deficits providing an important platform for mechanistic and therapeutic discovery.
    1. Developmental Biology
    2. Genetics and Genomics

    PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development

    Julia Raulino Lima, Nicha Ungvijanpunya ... Jian Xu
    IR-couple NMD controls matrix transcript abundance during craniofacial morphogenesis.
    1. Ecology
    2. Plant Biology

    Asymmetric introgression and thermal advantage jointly drive climate-mediated lineage turnover in a mixed-ploidy reed

    Lele Liu, Wenyi Sheng ... Weihua Guo
    Climate warming can silently replace cold-adapted native lineages with warm-adapted ones through asymmetric introgression and physiological advantages, a process overlooked by species-level forecasts.