Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Structural Biology and Molecular Biophysics

    In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles

    Zahra Seraj, Ximena Zottig ... Andrei A Korostelev
    Cryogenic electron microscopy of cellular extracts can visualize atomic details and discover new interactions between biological molecules, such as the interactions of the ribosome, the protein-making machinery, with essential proteins to regulate cellular functions.
    1. Developmental Biology
    2. Neuroscience

    Complementary vertebrate Wac models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome

    Kang-Han Lee, April M Stafford ... Daniel Vogt
    Two distinct vertebrate models were generated and phenotyped to study DESSH syndrome caused by the Wac gene.
    1. Neuroscience

    Sensitivity of the human temporal voice areas to nonhuman primate vocalizations

    Leonardo Ceravolo, Coralie Debracque ... Didier Grandjean
    Vocalizations of nonhuman primates, especially when acoustic and phylogenetic proximity is the highest, enhance human brain activity in the anterior temporal lobe.
    1. Neuroscience

    Frequency and laminar profile of feature-specific visual activity revealed by interleaved EEG–fMRI

    Tommy Clausner, José P Marques ... Mathilde Bonnefond
    Combined human laminar EEG–fMRI reveals feature-specific gamma band activity, and dissociates general (lower frequency) from feature-specific (higher frequency) alpha band activity related to superficial and deep cortical layers.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    A biochemical mechanism for Stu2/XMAP215-family microtubule polymerases

    Binnu Gangadharan, Daniel L Kober, Luke M Rice
    Evolutionarily unrelated microtubule and actin regulatory factors use the same mechanism to accelerate polymerization.
    1. Neuroscience

    Distinct sensorimotor encoding in tuft dendrites and somata associated with action, correction, and learning

    Jackson Scheib, Zachary L Newman ... Aaron Kerlin
    The tuft dendrites of neurons in the premotor cortex are uniquely selective for corrective actions, suggesting a specialized role in motor control and motor learning.
    1. Cell Biology

    Cardiolipin deficiency disrupts electron transport chain and drives steatohepatitis

    Marisa J Brothwell, Guoshen Cao ... Katsuhiko Funai
    Metabolic dysfunction-associated steatotic liver disease is associated with reduced mitochondrial cardiolipin concentration in mice and humans, and cardiolipin deficiency was sufficient to drive steatosis and fibrosis in the liver.
    1. Neuroscience

    Mesoscale functional architecture in medial posterior parietal cortex

    Riichiro Hira, Leah B Townsend ... Spencer LaVere Smith
    Medial PPC comprises two specialized modules, with AM integrating visual and choice signals and A representing choice history and posture.
    1. Neuroscience

    Brain cognition gaps reveal associations with dopamine and factors related to brain health through artificial intelligence prediction of functional connectome

    Morteza Esmaeili, Erin Beate Bjørkeli ... Alireza Salami
    Artificial intelligence and multimodal neuroimaging revealed brain state-dependent differences in the functional connectivity prediction of memory and identified the dopamine-modulated brain cognition gap as a marker of vulnerability to compromised brain function.
    1. Microbiology and Infectious Disease

    Membrane affinity difference between MinD monomer and dimer is not crucial for MinD gradient formation in Bacillus subtilis

    Laura C Bohorquez, Henrik Strahl ... Leendert Hamoen
    Diffusion rate difference between MinD monomer and dimer is important for MinD protein gradient formation in B. subtilis, and not membrane affinity difference.