Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Cryo-EM structures unexpectedly show that there are two binding sites for RAB5, with the VPS15 site being the most evolutionarily ancient site, which is essential for endocytic sorting.
Empirical substitution matrices from experimental measurements on 31,614 variants accurately predict cellular protein abundance changes using only amino-acid substitution and whether the site is buried or exposed.
Simone Daniela Rencken, Georgi Tushev ... Gilles Laurent
A chromosome-scale, annotated reference genome for the common cuttlefish Sepia officinalis clarifies its karyotype and reveals cephalopod-specific gene family expansions across neural and non-neural tissues.
Interaction between LFA-1 on natural killer cells and GBP-130 on infected erythrocytes enables immune recognition and killing of Plasmodium falciparum-infected red blood cells.
Thomas Moss, Alexandra Wooldredge ... Shaeri Mukherjee
A phosphorylation site on Hsp70 previously linked to pathogen activity functions endogenously in DNA damage responses and connects chaperone regulation to cell cycle control.
BRCA1/2 mutations rewire the lung adenocarcinoma microenvironment through distinct immune programs, with BRCA1-linked type I interferon signaling and CD8+ T activation contrasting BRCA2-linked MHC-II antigen presentation and CD4+ T differentiation.
Shoubhik Chandan Banerjee, Fritz A Francisco, Albert B Kao
A navigational model exploring social learning strategies differing in cognitive complexity in homing pigeons shows that simple averaging sufficiently explains collective route improvements, without requiring cumulative cultural evolution.
Glycolytic activation directly drives Kupffer cell loss in early metabolic dysfunction-associated steatotic liver disease, highlighting a targetable metabolic vulnerability.
