Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Stem Cells and Regenerative Medicine

    Synergistic inhibition of Notch signaling and forced cell cycle re-entry drive Müller glia reprogramming in uninjured mouse retina

    Baoshan Liao, Chengshang Lyu ... Wenjun Xiong
    Stimulating cell cycle entry and suppressing Notch signaling drive mammalian Müller glia to proliferate and generate diverse, long-surviving neuron-like cells, offering insights into overcoming retinal regeneration barriers.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites

    Deborah Maus, Elyzana Putrianti ... Martin Blume
    Inhibiting the mitochondrial bc1-complex disrupts energy production in mature Toxoplasma gondii bradyzoites, suggesting a metabolic vulnerability in the parasite's chronic, drug-resistant stage.
    1. Genetics and Genomics

    A systematic interactome of Saccharomyces cerevisiae SET1C expands its functional landscape and identifies candidate regulatory connections

    Pierre Luciano, Kihyun Park ... Vincent Geli
    A comprehensive two-hybrid map of the Set1C interactome broadens understanding of Set1C subunit functions and identifies a novel link between Set1C and arginine methylation.
    1. Neuroscience

    Modulating task-outcome value to mitigate real-world procrastination via noninvasive brain stimulation

    Zhiyi Chen, Zhilin Ren ... Tingyong Feng
    The perceived value of task outcomes, rather than task aversiveness, predicts reduced everyday procrastination following transcranial direct current stimulation, and offers a potential target for behavioral intervention.
    1. Biochemistry and Chemical Biology

    The chromokinesin Kid (KIF22) forms a homodimer, moves processively along microtubules, and transports double-stranded DNA

    Shinsuke Niwa, Natsuki Furusaki ... Kyoko Chiba
    Kid is reclassified as a processive chromokinesin that directly couples double-stranded DNA to microtubule-based transport.
    1. Neuroscience

    Larger language models better align with neural representations of natural language

    Zhuoqiao Hong, Haocheng Wang ... Ariel Y Goldstein
    Embeddings from larger language models and relatively earlier layers better predict neural activity during natural language.
    1. Computational and Systems Biology

    Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription, and splicing from single-cell RNA sequencing data with TSvelo

    Jiachen Li, Zhe Wang ... Ye Yuan
    TSvelo provides a comprehensive RNA velocity mathematics framework that can model the cascade of gene regulation, transcription, and splicing.
    1. Cell Biology
    2. Physics of Living Systems

    Sarcomere dynamic instability and stochastic heterogeneity drive robust cardiomyocyte contraction

    Daniel Haertter, Lara Hauke ... Christoph F Schmidt
    A non-monotonic force–velocity relationship in cardiac sarcomeres causes dynamic instability, leading to stochastic heterogeneity in contracting cardiomyocytes, which can have a protective function.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Acyl carrier protein is essential for apicoplast biogenesis in malaria parasites independent of fatty acid synthesis

    Sage WR Geher, Seyi Falekun ... Paul A Sigala
    Malaria parasites have evolved a noncanonical function for the apicoplast acyl carrier protein in stabilizing pyruvate kinase II, a metabolic hub essential for isoprenoid synthesis and parasite survival.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Intracellular growth of Chlamydia trachomatis leads to global histone hypermethylation by impairing demethylation

    Chloé I Charendorff, Félix V Louchez ... Agathe Subtil
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