Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Endogenous corazonin signaling modulates the post-mating switch in behavior and physiology in females of the brown planthopper and Drosophila

    Ning Zhang, Shao-Cong Su ... Shun-Fan Wu
    Endogenous corazonin signaling is a conserved female-driven regulator of the post-mating response in insects.
    1. Neuroscience

    Cross-modal interaction of human alpha activity does not reflect inhibition of early sensory processing in a frequency-tagging study using EEG and MEG

    Marion Brickwedde, Rupali Limachya ... Ali Mazaheri
    Early visual alpha oscillations correlate on a trial-by-trial basis with steady-state responses at later stages of the processing stream, implying a role in signal enhancement and interareal communication.
    1. Evolutionary Biology

    Recombination shapes the diversification of the wtf meiotic drivers

    Yan Wang, Hao Xu ... Guan-Zhu Han
    wtf genes, a poison-antidote meiotic driver, underwent recurrent and intricate recombination, which likely generates new meiotic drivers.
    1. Neuroscience

    Regime shift detection and neurocomputational substrates for under and overreactions to change

    Mu-Chen Wang, George Wu, Shih-Wei Wu
    In a stylized regime-shift detection task, human fMRI evidence shows that under- and overreactions to change arise from dissociable contributions of the frontoparietal network and ventromedial prefrontal cortex.
    1. Cell Biology
    2. Neuroscience

    Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in Drosophila

    Francisco Muñoz-Carvajal, Nicole Sanhueza ... Felipe A Court
    Age-related epigenetic regulation of mitochondrial stress responses drives neuronal degeneration and sensory decline, highlighting mitochondrial resilience as a potential target to preserve brain function during aging.
    1. Epidemiology and Global Health

    Prediction of SARS-CoV-2 transmission dynamics based on population-level cycle threshold values: An epidemic transmission and machine learning modeling study

    Afraz Arif Khan, Hind Sbihi ... Catherine A Hogan
    Modeling approaches demonstrate utility for incidence and reproductive number prediction and have potential to complement traditional surveillance in real time to guide public health interventions.
    1. Neuroscience

    Neural representation of time across complementary reference frames

    Yangwen Xu, Nicola Sartorato ... Roberto Bottini
    Humans’ flexible temporal cognition, including mental time travel, arises from perspective-agnostic encoding of event sequences in the hippocampus and perspective-dependent retrieval and reconstruction in the posterior parietal cortex.
    1. Genetics and Genomics

    Mettl5 coordinates protein production and degradation of PERIOD to regulate sleep in Drosophila

    Xiaoyu Wu, Xingzhuo Yang ... Juan Du
    The Mettl5/Trmt112 complex alters rRNA methylation, increasing PERIOD protein linking ribosome function, clock genes, and proteasome in sleep regulation in Drosophila.
    1. Ecology
    2. Evolutionary Biology

    Adaptive variation in avian eggshell gas conductance and structure across elevational gradients?

    David Ocampo, Carlos Daniel Cadena ... Gustavo A Londoño
    In Neotropical birds, eggshells show that water vapor conductance declines with elevation, but structural responses vary across species, suggesting no single underlying mechanism and highlighting the need to further evaluate eggshell traits as determinants of elevational limits.
    1. Cell Biology
    2. Developmental Biology

    A novel 3D visualization method in mice identifies the periportal lamellar complex (PLC) as a key regulator of hepatic ductal and neuronal branching morphogenesis

    Tongtong Xu, Fujun Cao ... Chengjian Zhao
    A high-resolution 3D imaging platform reveals the periportal lamellar complex as a novel structural feature in the mouse liver, regulating bile duct and nerve migration during fibrosis.