Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state

    Kexin Qi, Yuming Chai ... Quan Wen
    Serotonin promotes a sleep-independent quiescent state through selective modulation of motor neural population dynamics.
    1. Neuroscience

    Organization of circuits linking descending input to motor output in the Drosophila Male Adult Nerve Cord connectome

    Han SJ Cheong, Katharina Eichler ... Gwyneth M Card
    Circuit analyses of synaptic connectivity in networks connecting descending and motor neurons in the Drosophila Male Adult Nerve Cord connectome reveal the modular network organization of descending to motor pathways.
    1. Neuroscience

    Neural categorization of visual words of alphabetic and non-alphabetic languages

    Guo Zheng, Shihui Han
    Explaining the neural mechanisms underlying language-based, spontaneous categorization of visual words of alphabetic and non-alphabetic languages by combining electroencephalography, magnetoencephalography, and a repetition suppression paradigm.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    RNA selectively modulates activity of virulent amyloid PSMα3 and host-defense LL-37 via phase separation and aggregation dynamics

    Bader Rayan, Eilon Barnea ... Meytal Landau
    RNA differentially regulates the assembly pathways of bacterial and host α-helical peptides, revealing supramolecular architecture as a tunable determinant of cytotoxic and antimicrobial function.
    1. Structural Biology and Molecular Biophysics

    Enhanced processivity and collective force production of kinesin-1 at low radial forces

    Andrew M Hensley, Ahmet Yildiz
    Reducing vertical forces reveals kinesin-1 as a robust motor capable of sustaining high loads and efficiently generating large collective forces with multiple motors.
    1. Neuroscience

    The view tolerance of human identity recognition depends on horizontal face information

    Alexia Roux-Sibilon, Helene Dumont ... Valerie Goffaux
    View-tolerant identity recognition in humans depends on the stable identity cues provided by horizontal facial information.
    1. Cancer Biology
    2. Cell Biology

    DuoHexaBody-CD37 induces direct cytotoxic signaling in diffuse large B-cell lymphoma

    Simar Pal Singh, Kumar Mangalam ... Annemiek B van Spriel
    DuoHexaBody‑CD37 triggers complement‑independent cytotoxic signaling in diffuse large B-cell lymphoma (DLBCL), revealing therapeutic pathways that can be exploited to enhance tumor cell killing through targeted combination strategies.
    1. Neuroscience

    Serial dependence predicts generalization in perceptual learning

    Noga Pinchuk-Yacobi, Dov Sagi, Yoram S Bonneh
    A single temporal integration process links momentary perceptual biases to the generalization of learned skills, providing a unifying account of specificity versus flexibility in human learning.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2, and -3

    Crystal R Noell, Tzu-Chen Ma ... William O Hancock
    All three kinesin transport families exhibit unexpectedly slow dissociation under load, explaining robust competition with dynein during bidirectional cargo transport.
    1. Developmental Biology

    Paternal over- and under-nutrition programme fetal and placental development in a sex-specific manner in mice

    Hannah L Morgan, Nader Eid ... Adam J Watkins
    Poor paternal nutrition at the time of conception shapes post-fertilisation developmental trajectory, fetal growth, and placental dynamics.