Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Álvaro Escobar Doncel, Constantinos Patinios ... Colin J Ingham
Disrupting a single molybdenum cofactor gene allowed us to connect metabolic regulation of complex carbohydrates with cell organization, enabling genetic tuning of bacterial structural color for biomaterial applications.
Feedback signals to the early visual cortex convey both high-order and low-order visual information, but with different laminar profiles, and the high-order information is important for object recognition.
Constanza Salinas-Rebolledo, Javier Blesa ... Alejandro Rojas-Fernandez
Synthetic adaptors combining camelid nanobodies with the UBX domain of the p97 adaptor FAF1 enable targeted substrate delivery to p97, establishing an E3 ubiquitin ligase-independent mechanism for selective protein degradation.
A conserved signaling axis linking Drosophila adipose tissue to nephrocyte function reveals how obesity can drive kidney dysfunction and points to new opportunities for therapeutic intervention.
Gabriel Weindel, Jelmer P Borst, Leendert van Maanen
By modeling the single-trial electroencephalogram of participants performing perceptual decisions, and building on predictions from two century-old psychological laws, we estimate the times of information processing steps contained in decision-making.
F David Wandler, Benjamin K Lemberger ... James M Murray
A hierarchy of models guided by experimental results from zebrafish shows that coordinated, variable-speed locomotion can emerge from network-level interactions among interneuron populations with structured spatial connectivity.
Analysis of ~50 million articles published in ~50 thousand journals demonstrates that journals have become more diverse in terms of both interdisciplinarity and internationalization but with some disciplinary differences.
Anastasia Unitt, Made A Krisna ... Odile B Harrison
LIN code offers a reliable framework for classifying gonococcal population structure, enabling straightforward exploration of isolate relationships, from broad superlineage divisions to minute single allele differences.
Antigen-driven TCR signaling in the epidermis during CD8+ TRM differentiation results in a lower TGFβ requirement for persistence and increased proliferative capacity that together enhance epidermal TRM fitness.
