Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Deficiency in any of the interdependent C2a proteins (CCDC108, MYCBPAP, and CFAP70) collapses this central pair microtubule-associated projection, disrupting vertebrate ciliary movement, and causing primary ciliary dyskinesia phenotypes in mice.
Two families of ubiquitin ligases secreted by the intracellular pathogen Legionella pneumophila utilize distinct chemistries to form a stable, ubiquitin-rich structure around the vacuole, which is subsequently disassembled as infection progresses.
Peter Georgiev, Sheila Johnson ... Arlene H Sharpe
A comprehensive investigation of extracellular asparagine utilization highlights its role as a critical regulator of murine CD4+ T cell activation, differentiation, and function.
Lenacapavir disrupts HIV-1 capsid elasticity, inducing mechanical rupture at the nuclear pore, highlighting that altering viral material properties can be a viable antiviral drug design strategy.
The yeast mitochondrial malate dehydrogenase–citrate synthase metabolon is a dynamic multienzyme complex that continuously assembles and disassembles in response to respiratory activity, mitochondrial matrix pH, and substrate abundances.
Michael B Heskett, Athanasios E Vouzas ... Mathew J Thayer
Stable allele-specific epigenetic regulation creates cellular mosaicism of numerous autosomal dosage-sensitive genes involved in human neurological and developmental disorders.
