Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Anterior cingulate cortex monitors action state and action content in complex associative learning

    Wenqiang Huang, Arron F Hall ... Dong V Wang
    ACC contains specialized neurons that sustain rich action-relevant information after action execution, enabling prolonged action monitoring, and supporting complex associative linking across events.
    1. Neuroscience

    How attention simplifies mental representations for planning

    Jason da Silva Castanheira, Christina Chang He ... Stephen M Fleming
    Spatial attention controls the information people become aware of and, in turn, incorporate into simplified perceptual representations for use in multi-step planning.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Inferring variant-specific effective reproduction numbers from combined case and sequencing data

    Marlin D Figgins, Trevor Bedford
    Integrating case counts with genomic sequences quantifies real-time transmission advantages of viral variants.
    1. Developmental Biology
    2. Neuroscience

    The microtubule-binding protein EML3 is required for mammalian embryonic growth and cerebral cortical development, and Eml3 null mice are a model of cobblestone brain malformation

    Isabelle Carrier, Eduardo Diez ... Roderick McInnes
    Absence of EML3 in mice leads to delayed embryonic development, small size, perinatal lethality, and the over-migration of neuroblasts due to a defective pial basement membrane.
    1. Microbiology and Infectious Disease

    The targeted cytosolic degradation of class I histone deacetylases is essential for efficient alphaherpesvirus replication

    Sheng-Li Ming, Meng-Hua Du ... Bei-Bei Chu
    Alphaherpesviruses hijack host epigenetic regulation by promoting HDAC1/2 nuclear export and degradation to activate the DNA damage response, revealing new antiviral therapeutic targets.
    1. Neuroscience

    Theta beta ratio in attention deficit hyperactivity disorder using a multiverse analysis

    Dawid Strzelczyk, Andrea Vetsch, Nicolas Langer
    Individual alpha peak frequency and aperiodic neural activity shape theta-beta ratio estimates, limiting their value as an ADHD biomarker.
    1. Neuroscience

    Kinematic signatures in reaching movements during spaceflight provide evidence that humans underestimate body mass in microgravity

    Zhaoran Zhang, Yu Tian ... Kunlin Wei
    Model-based kinematic analyses link the movement slowing in spaceflight to body mass underestimation.
    1. Computational and Systems Biology
    2. Neuroscience

    Comparing the outputs of intramural and extramural grants funded by National Institutes of Health

    Xiang Zheng, Qiyao Yang ... B Ian Hutchins
    Funding mechanisms impact the cost effectiveness of the science conducted, as extramural NIH grants to universities excel at producing papers and citations, while intramural NIH hiring more effectively translates to clinical impact.
    1. Structural Biology and Molecular Biophysics

    Lenacapavir-induced lattice hyperstabilization is central to HIV-1 capsid failure at the nuclear pore complex and in the cytoplasm

    Arpa Hudait, Ryan C Burdick ... Gregory A Voth
    Lenacapavir disrupts HIV-1 capsid elasticity, inducing mechanical rupture at the nuclear pore, highlighting that altering viral material properties can be a viable antiviral drug design strategy.
    1. Immunology and Inflammation

    TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy

    Josselyn D Barahona, Liping Yang ... Wayne M Yokoyama
    Uterine natural killer (NK) cells require TGF-β to be derived from conventional NK cells and contribute to successful pregnancy.