Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Developmental Biology
    2. Genetics and Genomics

    Multiple molecular pathways to longevity with opposing gene expression programs defining distinct aging strategies in Caenorhabditis elegans

    Zenith D Rudich, Jiaxi Guan ... Jeremy M Van Raamsdonk
    Comparing gene expression across a panel of nine long-lived mutants in a single study reveals that these mutants utilize both common and unique genetic strategies to achieve long life.
    1. Neuroscience

    Neural computations in the foveal and peripheral visual fields during active search

    Jie Zhang, Xiaocang Zhu ... Huihui Zhou
    Foveal attentional processing coordinates with peripheral attention to dynamically shape global attention allocation and fixation behavior during active vision.
    1. Computational and Systems Biology

    Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females

    Hélène Vantomme, Valentin Quiniou ... David Klatzmann
    Sex-specific biases in thymic T cell receptor selection enrich female CD8 T cell repertoires for autoimmunity-associated self-antigens, helping explain women’s increased susceptibility to autoimmune diseases.
    1. Neuroscience

    Visuomotor mismatch EEG responses over occipital cortex of freely moving human subjects

    Magdalena Solyga, Marek Zelechowski, Georg B Keller
    Visuomotor mismatch events elicit robust human prediction error responses that exceed conventional oddball mismatch negativity, enabling translation of sensorimotor prediction mechanisms from mice to humans.
    1. Epidemiology and Global Health

    Heterogeneity of use, access, and retention of insecticide-treated nets: Implications for subnational tailoring to maximise malaria control

    Andrew C Glover, Hannah Koenker ... Thomas S Churcher
    While transmission intensity should still drive where insecticide-treated nets are prioritised, deprioritising areas where people are more likely to use nets may cause larger case resurgences than otherwise expected.
    1. Physics of Living Systems

    Viral commitment to infection depends on host metabolism

    Anastasios Marantos, Kim Sneppen ... Namiko Mitarai
    Energy-limited bacterial cells reduce phage adsorption, particularly for weakly binding viruses, revealing host physiology as a key factor in viral commitment to infection.
    1. Microbiology and Infectious Disease

    Three metabolic pathways replenishing the one-carbon pool collectively support growth and virulence of Listeria monocytogenes

    Sandra Freier, Sarah Frentzel ... Sven Halbedel
    Spontaneous reactivation of an interrupted biosynthetic gene reveals unexpected plasticity in folate-dependent one-carbon metabolism that promotes growth and virulence in the foodborne human pathogen Listeria monocytogenes.
    1. Neuroscience

    Overt visual attention modulates decision-related signals in the frontal cortex

    Blair RK Shevlin, Rachael Gwinn ... Ian Krajbich
    Brain activity in the pre-supplementary motor area and dorsolateral prefrontal cortex represents gaze-weighted accumulated evidence signals in value-based decision-making.
    1. Neuroscience

    α/β-Hydrolase domain-containing 6 (ABHD6) accelerates the desensitization and deactivation of TARP γ-2-containing AMPA receptors

    Rixu Cong, Huiran Li ... Chen Zhang
    The gating kinetics of AMPARs are regulated by ABHD6 in a TARP γ-2-dependent manner.
    1. Cell Biology
    2. Immunology and Inflammation

    MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide

    Michelle C Rice, Maria Imun ... Changhan Lee
    MOTS-c, a mitochondrial-encoded microprotein, has immunological origins and functions, revealing for the first time that our immune system is encoded by both co-evolved nuclear and mitochondrial genomes.