Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
In an assay focusing on active virus recruitment rather than passive binding, STED microscopy reveals early association of virions to CD151, indicating its early involvement in viral entry platforms formation.
Kathleen S Metz Reed, Andrew Fritz ... Tom Misteli
Genome-wide maps of chromatin structure in a cell-based model of breast cancer reveal chromatin reorganization accompanied by changes in transcription and epigenetic marks.
Iman Hamid, Ólavur Mortensen ... Noomi O Gregersen
Present-day Faroese genomes reveal ancestry, bottleneck history, and signatures of selection, and offer a foundation for understanding the genetic architecture of health and disease in this North Atlantic founder population.
Analyses of two independent phylogenomic datasets suggest an explosive radiation at the origin of Spiralia, with implications for understanding the group's evolutionary history.
Fidel Emmanuel Serrano, Daniela Marzoll ... Michael Brunner
Repressive PER2:CRY1:CK1δ complexes assembling in the cytosol enter the nucleus, where PER2 hyperphosphorylation eventually disrupts the complex, causing PER2 to relocalize to the cytoplasm, allowing nuclear accumulation of CRY1.
Ariunaa Bayanjargal, Cenny Taslim ... Emily Rose Theisen
A discrete helix in the fusion oncoprotein DNA binding domain shifts binding preferences toward long and dense GGAA repeats, which promotes transcriptional hub formation and drives EWSR1::FLI1-mediated gene regulation.
Christopher D Adam, Ehsan Mirzakhalili ... John A Wolf
Experimental TBI results in distinct patterns of network-level pathophysiology in the hippocampus that may contribute to TBI-associated cognitive deficits.
