Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Bruno Gideon Bergheim, Alison G Cole ... Suat Özbek
Integrated proteomic and single-cell transcriptomic analyses define the Nematostella vectensis matrisome and reveal conserved extracellular matrix functions driving life cycle transitions in this non-bilaterian model.
Theoretical and computational analyses reveal environmental, compositional, kinetic, and thermodynamic constraints on a scenario where sequence information collectively stored in pools of RNA molecules is replicated via non-enzymatic RNA ligation.
Brain fluidity metrics provide an accessible and reliable marker of consciousness, offering a practical alternative to perturbational complexity for clinical and research applications.
Predicting key future moments requires ignoring most irrelevant time, and alpha and beta power modulations encode sequential temporal landmarks via a gain-control mechanism that suppresses these irrelevant periods.
Luis G Palma, Daniel Alvarez-Villanueva ... Anna Bigas
The development of novel separation-of-function mutants has uncovered non-canonical chromatin roles of IκBα in regulating mouse embryonic stem cell pluripotency and differentiation, independently of the classical NF-κB pathway.
Chrispin Chaguza, Daan W Arends ... Amelieke JH Cremers
The pneumococcal capsular serotype and genetic background, as well as a combination of genomic loci, influence intrinsic pneumococcal growth kinetics, which may have implications for pneumococcal disease pathogenesis.
Pharmacological disruption of TopBP1 condensation impairs ATR signaling, promotes DNA damage and apoptosis, and enhances the efficacy of FOLFIRI chemotherapy in colorectal cancer.
