Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Keratinocytes, which activate an EMT-like program in the skin, can prevent melanoma invasion, highlighting how changes in the tumor microenvironment can act as restraining forces in cancer.
Eutherian mammals living in China after the end-Cretaceous extinctions evolved larger tooth sizes first before becoming more specialized in their biting performance, mirroring a similar pattern in brain evolution.
Christopher Zhe Wei Lee, Farah Tasnim ... Florent Ginhoux
Co-culturing pluripotent stem cell-derived hepatocytes and macrophages establishes a physiologically relevant liver model that captures macrophage–hepatocyte interactions, significantly improves hepatocyte maturation, and enables more accurate prediction of immune-mediated drug toxicity.
Fine-scale exogenous attention within the foveola selectively enhances contrast gain at low-to-mid spatial frequencies while increasing response gain across a broad spatial frequency range.
Optical imaging and optogenetic inactivation of dorsal mouse neocortex reveal an unexpected role for retrosplenial cortex in the context-dependent transformation of whisker sensory information into licking for a water reward.
Kirill Lotonin, Francisco Brito ... Artur Summerfield
Dissecting protective versus detrimental immune responses uncovers biomarkers and mechanisms that can inform the rational design and evaluation of live attenuated vaccines against African swine fever virus.
Large-scale all-atom simulations of a full-length, glycosylated HIV-1 Env trimer in an asymmetric membrane reveal a rigid ectodomain and highly diverse conformational landscapes in the membrane-proximal region and transmembrane domain.
Arnau Pujol, Arlindo Chidimatembue ... Alfredo Mayor
Malaria importation in Matutuine district from southern Mozambique is strongly contributing to sustaining transmission, with Inhambane province being the main source of importation.
