Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Epidemiology and Global Health

    A natural experiment in Kenya reveals durable immunosuppressive effects of early childhood malaria: a longitudinal cohort study

    Mercy S Safari, Timothy O Makori ... Charles J Sande
    Early-life malaria exposure leaves a durable immunological imprint associated with reduced antibody responses to unrelated infections and vaccines.
    1. Neuroscience

    Human cerebellum and ventral tegmental area interact during extinction of learned fear

    Enzo Nio, Patrick Pais Pereira ... Dagmar Timmann
    The cerebellum and ventral tegmental area interact during unexpected omissions of aversive outcomes in humans, supporting a role for reward-like prediction error signaling in fear extinction learning.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Experimental verification of the error minimization theory using non-standard genetic codes constructed in vitro

    Ryota Miyachi, Norikazu Ichihashi
    The in vitro experiments that used the artificial genetic codes tested here did not provide support for the error minimization theory.
    1. Cell Biology

    Cytoplasmic circular dsDNA is a key constituent of stress granules

    Natalia A Demeshkina, Adrian R Ferré-D'Amaré
    Extrachromosomal circular DNA has been identified as a novel component of stress granule cores, indicating its essential involvement in eukaryotic stress response pathways at the level of protein synthesis.
    1. Neuroscience

    Anterior cingulate cortex monitors action state and action content in complex associative learning

    Wenqiang Huang, Arron F Hall ... Dong V Wang
    ACC contains specialized neurons that sustain rich action-relevant information after action execution, enabling prolonged action monitoring, and supporting complex associative linking across events.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Inferring variant-specific effective reproduction numbers from combined case and sequencing data

    Marlin D Figgins, Trevor Bedford
    Integrating case counts with genomic sequences quantifies real-time transmission advantages of viral variants.
    1. Neuroscience

    Kinematic signatures in reaching movements during spaceflight provide evidence that humans underestimate body mass in microgravity

    Zhaoran Zhang, Yu Tian ... Kunlin Wei
    Model-based kinematic analyses link the movement slowing in spaceflight to body mass underestimation.
    1. Computational and Systems Biology
    2. Neuroscience

    Comparing the outputs of intramural and extramural grants funded by National Institutes of Health

    Xiang Zheng, Qiyao Yang ... B Ian Hutchins
    Funding mechanisms impact the cost effectiveness of the science conducted, as extramural NIH grants to universities excel at producing papers and citations, while intramural NIH hiring more effectively translates to clinical impact.
    1. Neuroscience

    Theta beta ratio in attention deficit hyperactivity disorder using a multiverse analysis

    Dawid Strzelczyk, Andrea Vetsch, Nicolas Langer
    Individual alpha peak frequency and aperiodic neural activity shape theta-beta ratio estimates, limiting their value as an ADHD biomarker.
    1. Neuroscience

    How attention simplifies mental representations for planning

    Jason da Silva Castanheira, Christina Chang He ... Stephen M Fleming
    Spatial attention controls the information people become aware of and, in turn, incorporate into simplified perceptual representations for use in multi-step planning.