Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
In complex life cycle taxa, the relationship between functional traits and threat status varies across developmental stages, making adult‑based threat predictions insufficient to reflect risks faced during other life stages.
Justin D Shin, Michael Satchell ... Shantanu P Jadhav
Rapid eye movement (REM) sleep organizes sparse, sequential cortical reactivation through chains of prefrontal high-frequency oscillations coupled to hippocampal theta, an inter-regional dialogue distinct from that of non-REM ripples.
Anda de Witte, Anouck Matthijs ... Jean-Jacques Orban de Xivry
Cerebellar-dependent functions are mostly maintained or even enhanced across the lifespan, with cerebellar-mediated motor abilities remaining intact despite degeneration, in contrast to non-cerebellar measures.
Warm temperature promotes gonadal transformation of ricefield eel by inducing the expression of male pathway genes in ovaries via the Trpv4-pStat3-Kdm6b-Dmrt1 axis.
Polo-like kinase phosphorylation of the centrin arm-localized orphan kinesin KIN-G disrupts its microtubule-binding activity and inhibits centrin arm biogenesis in trypanosomes.
Extracellular DNA degrades at markedly different rates across soils and sequences, substantially biasing estimates of prokaryotic abundance, diversity, and community composition.
Noradrenergic tone varies with arousal state, is inversely correlated with hippocampal ripple and sleep spindle oscillations, and differs according to ripple–spindle coupling, with potential implications for synaptic and systems consolidation.
Multimodal data-driven computational modeling reveals that realistic cortical connectivity can generate more macroscopic traveling waves than local or uniform connectivity in the mouse cortex.
Squidly enables efficient identification of enzyme catalytic residues by integrating functional hierarchies into a contrastive learning framework, requiring only protein sequences to produce scalable predictions across the known enzyme landscape.
Jenny A Hurcombe, Lusyan Dayalan ... Richard JM Coward
Simultaneously knocking down both the insulin and IGF1 receptor in the kidney podocyte is highly detrimental, affecting spliceosome function and gene transcription.
