Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Relationship between cognitive abilities and mental health as represented by cognitive abilities at the neural and genetic levels of analysis

    Yue Wang, Richard Anney, Narun Pat
    Multimodal neuroimaging explained 66% of the cognitive–mental health link in children, outperforming polygenic scores (21%), and accounted for 58% of the environmental contribution to this relationship.
    1. Cell Biology

    Membrane potential modulates ERK activity and cell proliferation in human cells

    Mari Sasaki, Masanobu Nakahara ... Fumihito Ono
    Membrane depolarization promotes extracellular signal-regulated kinase activation and cell proliferation via phosphatidylserine dynamics.
    1. Neuroscience

    Elevated DNA damage without signs of aging in the short-sleeping Mexican cavefish

    Evan Lloyd, Fanning Xia ... Alex C Keene
    Cavefish exhibit resilience to chronic sleep loss and tolerate elevated DNA damage and reduced DNA repair responses without compromising healthspan or longevity.
    1. Biochemistry and Chemical Biology

    Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

    Yasuhiro Shinkai, Yunjie Ding ... Yoshito Kumagai
    The hold-and-release regulation of zinc by GIF/MT-3 is mediated by sulfane sulfur through a redox-dependent switching mechanism.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Repeated vaccination with homologous influenza hemagglutinin broadens human antibody responses to unmatched flu viruses

    Yixiang Deng, Melbourne Tang ... Daniel Lingwood
    Classical antibody boosting effects during vaccination are accompanied by natural broadening mechanisms that help enable human antibodies to engage conserved sites of vulnerability on influenza virus.
    1. Structural Biology and Molecular Biophysics

    Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases

    Jianing Liu, Anokhi Shah ... Keni Vidilaseris
    Distinct asymmetric states in membrane-bound pyrophosphatases reveal how inhibitors block their activity and inform drug development.
    1. Cell Biology
    2. Immunology and Inflammation

    Engineered migrasomes provide a robust and thermally stable vaccination platform

    Dongju Wang, Haifang Wang ... Zhihua Liu
    Integration of migrasome-inspired biology with hypotonic shock-mediated vesicle generation establishes a durable and versatile platform for vaccine development.
    1. Neuroscience

    Animacy semantic network supports causal inferences about illness

    Miriam Hauptman, Marina Bedny
    Making causal inferences about illness, compared to making causal inferences about mechanical breakdown and reading causally unconnected sentences, activates a semantic brain network implicated in the conceptual representation of animate entities (e.g. people, animals).
    1. Computational and Systems Biology
    2. Neuroscience

    Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila

    Jayati Gera, Marishia Agard ... Meet Zandawala
    A multi-pronged approach reveals that ion transport peptide neuropeptide acts through the guanylate cyclase receptor Gyc76C to coordinate osmotic and metabolic homeostasis across multiple tissues in Drosophila.