Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Bruno Miranda, James L Butler ... Steven W Kennerley
Single-neuron recordings reveal that anterior cingulate cortex and caudate nucleus encode the interaction between rewards, state transitions, and choices that underlies flexible, goal-directed decision-making.
Kenji J Nishimura, Denisse Paredes ... Michael R Drew
Chemogenetic and in vivo recording approaches reveal how persistent hyperactivity in the posterior paraventricular thalamus promotes sensitization of fear responses to unlearned threats after stress exposure.
Megan S Laham, Martha S Ackerman-Berrier ... Gregory RJ Thatcher
Coregulator TR-FRET profiling reveals ligand-specific LXR signaling signatures that can guide the therapeutic design of ABCA1-inducing LXR agonists with attenuated risk of hepatic lipogenesis.
CLas hijacks the DA/DcDop2-miR-31a-AKH-JH signaling cascade to improve D. citri lipid metabolism and fecundity, while simultaneously promoting its replication.
Long-term motor recovery after musculoskeletal alteration relies on gradually developing novel compensatory movements to overcome the rigid, maladaptive timing of stable muscle synergies.
Koichi Hashikawa, Yoshiko Hashikawa ... Garret D Stuber
Esr1 directs adolescent transcriptional maturation of medial preoptic GABAergic neurons, enabling the normal development of mating behavior in male and female mice.
Tunable Bessel beam two-photon fluorescence microscopy enables high-speed volumetric intravital imaging of subcellular dynamics within living mouse brains with fully tunable spatial resolution and volume coverage, allowing flexible sampling and measurements of vascular, neuronal, and immune dynamics.
A multi-step ribosome assembly method involving changes in ion concentration and temperature can now be carried out in a single step using the two GTPase factors, EngA and ObgE.
Tom Louis Ducrocq, Damien Laporte, Bertrand Daignan-Fornier
A genetic analysis in yeast establishes that multicellularity can arise as a side-effect (passenger phenotype) of a completely independent fitness advantage unrelated to the benefits of group formation itself.
Disrupting oligodendrocytes during a narrow early-life window leaves cerebellar circuits permanently mistimed, but adult re-synchronization restores social and motor behavior.
