Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Gabriela Giordano, Robin Buratowski ... Stephen Buratowski
The TFIIH subunit Tfb3/MAT1 can be split into two parts to uncouple the TFIIH kinase and DNA translocase modules, resulting in unfocused C-terminal domain phosphorylation.
Helge Feddersen, Charlotte Dyckmans, Marc Bramkamp
Dynamic relocalization of MinD in Bacillus subtilis arises from membrane binding of monomers and dimers with membrane-triggered ATP hydrolysis, suggesting MinE-like activators are unnecessary for Min system dynamics.
Arousal signals are present in the superior colliculus but appear to be organized in a way that they avoid directly triggering motor plans that lead to saccades.
Integrative structural analysis identifies the structural basis and key residues responsible for IDE conformational dynamics that control the unfolding and selective degradation of amyloid peptides.
Kasturi Biswas, Caroline Moore ... Michael M Francis
Muscarinic cholinergic signaling links neural activity to organism‑wide transcriptional and proteostatic responses that protect against chronic oxidative stress.
Fernanda T Subtil, Teresa FG Machado ... Luiz Pedro S de Carvalho
Using macroevolution, species not strains, uncovered important diversity in how mycobacteria respond to and resist antibiotics, revealing novel resistance determinants.
Chiara Bulgarelli, Anna Blasi ... The BRIGHT Study Team
In Gambian infants, positive growth from 0 to 5 months of age predicted more mature brain networks, which in turn predicted cognitive outcomes at 3-5 years.
Transcriptome-wide profiling of bacterial RNA pseudouridylation maps modification landscapes and nominates candidate regulatory sites, offering a resource and foundation for future mechanistic studies of Ψ function in bacteria.
