Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    A stress-activated neuronal ensemble in the supramammillary nucleus produces anxiety-like behavior in male mice

    Jinming Zhang, Kexin Yu ... Jing Han
    Stress-recruited neurons can cause anxiety-like avoidance and increase peripheral corticosterone concentration.
    1. Chromosomes and Gene Expression

    TAD boundaries and gene activity are uncoupled

    Faisal Almansour, Nadezda A Fursova ... Tom Misteli
    Single-cell analysis fails to find a functional link between the organization of chromatin domain organization and gene activity.
    1. Neuroscience

    Endogenous precision of the number sense

    Arthur Prat-Carrabin, Michael Woodford
    A theory of efficient coding wherein the precision of representations is endogenous, task-dependent, and prior-dependent predicts scaling laws for imprecision and is supported by numerosity perception experiments with humans.
    1. Developmental Biology

    Heterogeneity of Sonic Hedgehog response dynamics and fate specification in single neural progenitors

    Fengzhu Xiong, Andrea R Tentner ... Sean G Tsung-Megason
    Comparing signaling response profiles and fate outcomes in single cells reveals logic and limits of signal interpretation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A lipoprotein partner for the Escherichia coli outer membrane protein TolC

    Jim Horne, Elise Kaplan ... Ben F Luisi
    Structural and biochemical analyses identify a bacterial lipoprotein that associates with the outer membrane component of tripartite multi-drug efflux pumps, and its potential functional roles are explored by complementary bioinformatics, proteomcid and genetic approaches.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Epigenetics and chromatin structure regulate var2csa expression and the placental-binding phenotype in Plasmodium falciparum

    Todd Lenz, Madle Sirel ... Ulf Ribacke
    Placenta-binding parasites show that chromatin-based mechanisms regulate placental malaria virulence gene, var2csa, and requires loss of H3K9me3-mediated heterochromatic silencing and 3D nuclear repositioning away from telomeric-repressive clusters.
    1. Neuroscience

    Fear conditioning biases olfactory sensory neuron frequencies across generations

    Clara W Liff, Yasmine R Ayman ... Bianca J Marlin
    Olfactory fear conditioning biases olfactory stem cell receptor fate, increasing the frequency by which maturing neurons express the receptor of the paired odor and changing the representation of the olfactory sensory neuron landscape in the next generation.
    1. Structural Biology and Molecular Biophysics

    Active regulation of the epidermal growth factor receptor by the membrane bilayer

    Shwetha Srinivasan, Xingcheng Lin ... Gabriela S Schlau-Cohen
    Membrane composition modulates EGFR conformational dynamics and signaling, revealing that the bilayer properties can override ligand control to influence receptor activation in health and disease.
    1. Genetics and Genomics
    2. Physics of Living Systems

    Revealing global stoichiometry conservation architecture in cells from Raman spectral patterns

    Ken-ichiro F Kamei, Koseki J Kobayashi-Kirschvink ... Yuichi Wakamoto
    Conservation levels of gene expression abundance ratios are globally coordinated in cells, and cellular state changes under such biologically relevant stoichiometric constraints are readable as low-dimensional changes in Raman spectra.