Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
A computational model of the striatal dopamine system predicts transporter expression and organisation as key determinants of regional striatal dopamine dynamics and distinct signal decoding by D1 and D2 receptors.
Combining statistical modeling with flow cytometry enables reliable, high-throughput quantification of division asymmetry in live cells, revealing how partitioning noise may shape tumor cell heterogeneity.
Single-cell transcriptomic analysis of the murine testicular interstitium across the lifespan reveals Cd34+/Sox4+ mesenchymal cells as Leydig progenitors, whose aging-associated decline in glutathione and Sox4-regulated regenerative capacity inform potential therapeutic strategies for age-related testicular dysfunction.
Low-level features of peripheral saccade targets are fed back to early foveal retinotopic cortex in a signal that resembles activation elicited by direct foveal presentation.
Genetic and electrophysiological studies uncover a mechanism linking a TTN missense variant to atrial fibrillation by coupling titin with potassium channel remodeling, revealing FHL2 as a modulator and therapeutic target.
Identification of a nitric oxide-regulated transitional state of Müller glia reveals a key mechanism enabling neuronal regeneration in the injured vertebrate retina.
Samuel J Rosen, Olivier Witteveen ... Maxwell Z Wilson
Human cells decode dynamics Wnt signals using an anti-resonant filter that suppresses intermediate-frequency inputs and is capable of redirecting developmental fate outcomes, including germ-layer specification.
Clinically relevant Ω-loop mutations in PDC-3 reshape active-site dynamics to enhance β-lactamase activity, providing mechanistic insights that can guide the rational design of inhibitors.
Single-cell transcriptomics identifies three discrete mouse trabecular meshwork subtypes and demonstrates that an Lmx1b glaucoma mutation drives mitochondrial dysfunction and elevated intraocular pressure, which is lessened by vitamin B3 supplementation.
