Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Andrés B Crane, Michiko O Inouye ... J Troy Littleton
Patch-seq RNA profiling defines the overall RNA editing landscape and single neuron editing rules for individual genetically defined Drosophila larval motoneurons.
Fireflies that gather in swarms synchronize their flashing with rhythmic periodicity and provide insights into a new mechanism for the emergence of synchrony and periodicity.
Rahul K Suryawanshi, Priyadarshini Jaishankar ... James S Fraser
The development of new small molecules demonstrates how pharmacologic inhibition of the coronavirus macrodomain restores innate immunity, leading to reduced viral replication and improved outcomes in severe infection.
Rebecca Garrett Jaszczak, Jay W Zussman ... Diana J Laird
A temporal and positional atlas of mouse primordial germ cell (PGC) migration reveals dynamic gene expression and somatic cell interactions that suggest how changing migratory niches regulate PGC development.
A key finding is that MCAK binds to the proximal region of GTP cap where GDP‧Pi-tubulins accumulate, in addition to curved protofilaments at the distalmost tip.
The path of potassium through an ATP-dependent membrane pump is elucidated with a high-resolution structure within a lipid bilayer together with mutational analysis at key points along this pathway.
Chromosome-driven DnaA activity oscillations, modulated by DNA-binding proteins, enable bacteria to coordinate DNA replication with biomass growth independently of transcriptional regulation.
