Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
The pathogenicity of MECP2 C-terminal deletions is determined by translational reading frame, enabling prediction of clinical outcome and a shared therapeutic genome editing strategy.
Carolyne Jie Huang, Samuel Pawel ... Rachel Heyard
A simulation study shows that metrics suggested to assess replication studies are useful in the translation context, but researchers need to clarify their translation goals a priori.
Separate prefrontal output channels preferentially track anxiety, exploration, and social preference, revealing how emotional context is organized into adaptive behavior.
LRRK2 couples brain-derived neurotrophic factor (BDNF) signaling to synaptic actin remodeling, defining a novel mechanism of LRRK2 synaptic function and highlighting early, targetable pathways in Parkinson’s disease.
The genomic response of endothelial cells to hypoxia via MOA-seq transcription factor occupancy profiling identified known and novel HIF1A-associated and independent cis-regulatory elements, which defined ten distinct hypoxic kinetic clusters.
Camilla Do, Keiko Christine Salazar ... Anthony W Maresso
Targeted ecological sampling combined with a portable enrichment device rapidly yields a diverse array of bacteriophages against drug-resistant pathogens.
