Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
A comparative analysis of genome-wide seasonal gene expression dynamics across four forest tree species revealed that a shared 'molecular calendar' emerges in winter, constraining gene expression evolution and potentially limiting temporal niche partitioning and species divergence in seasonal environments.
Mitochondrial remodeling, ROS-dependent signaling, and diverse environmental and physiological cues underlie the initiation and persistence of locomotory activity of C. elegans in toxic H2S.
Multi-omics analyses reveal redundant functions of yeast mRNA decapping activators Scd6 and Edc3 in facilitating recruitment of helicase Dhh1 and accelerating degradation of transcripts required for respiration in glucose-replete cells.
A deep generative approach learns the translation from neurons’ electrophysiological recordings to the biophysical parameters of neuron models, assisting in the development of a detailed nervous system model.
Integrative analyses uncover RBMX2 as a pivotal mediator that bridges Mycobacterium bovis infection to epithelial–mesenchymal transition and tumor progression in the lung.
Julia J van Adrichem, Rolinka J van der Loo ... Ronald E van Kesteren
Remote memories in Alzheimer’s disease are impaired through loss of inhibitory control over cortical engram neurons by hyperexcitable parvalbumin interneurons.
Cell-line experiments and in vivo functional experiments provide the evidence that CT-type peptides can act as ligands for both CTR/CLR-type and PDF-type receptors in a deuterostome.
PTBP1 loss in mature astrocytes causes unique astrocytic splicing changes, not neuronal-like, contrasting its role in other non-neuronal cells and indicating PTBP1 depletion alone is ineffective to drive adult-astrocyte-to-neuron conversion.
