Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Lipid binding stabilizes the SARS-CoV-2 Orf9b homodimer, slowing its conversion to the Tom70-binding monomeric form and modulating interferon suppression.
HPV cfDNA is a highly effective tumor marker for monitoring disease progression and treatment response in HPV-positive cervical cancer, offering valuable insights for guiding clinical decisions in precision medicine.
Sex-biased gene expression in the body organs evolves rapidly, supporting a mosaic model of maleness and femaleness across tissues and thus challenging binary views of sex characteristics in mammals.
A neutrality index identifies mox-YG as a minimally cytotoxic protein, enabling ultra-high expression and uncovering key physiological consequences of protein burden.
Ojas Natarajan, Susanne L Gibboney ... Larry J Dishaw
Deleting SfPat prophage reduces Shewanella fidelis motility, increases biofilms, changes pdeB expression and spatial retention in Ciona gut, while Ciona VCBP-C binding to the WT strain results in reduced expression of viral capsid proteins without inducing SOS, indicating tripartite interactions.
Combining computer modeling and experiments in animals shows that the spatial organization of thymic epithelial cells affects the availability of signaling molecules that regulate thymocyte proliferation and development.
Sleep is essential for consolidating implicitly acquired perceptual knowledge that enables the knowledge transfer effect via newly learned structured information observed in prior studies of explicit learning.
María Pedraza, Valentina Grampa ... Justine Masson
KIF7 loss of function affects several developmental stages of the cerebral cortex and likely causes neurodevelopmental delay, intellectual disability, and epilepsia observed in ciliopathic patients with KIF7 mutations.
