Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Sebastián Cruz-Gonzalez, Ogechukwu Okpala ... John A Capra
DNA-methylation-based predictors of biological age often fail to generalize across human populations, limiting their utility as biomarkers of aging and disease.
Heterogeneity in outcomes of differently located activating mutations of Notch indicates the need and potential for mutant specific targeting of Notch in cancer.
David C Gruskin, Daniel J Vieira ... Gaurav H Patel
Genetic influences on how the brain processes complex naturalistic stimuli can be traced back to inherited control over stable spatial and temporal features of brain function.
Yanaira Alonso Caraballo, Yan Li ... Elena Chartoff
Prolonged oxycodone abstinence strengthens paraventricular thalamus to nucleus accumbens shell glutamatergic transmission in both sexes, yet only females show enhanced relapse, dissociating shared synaptic plasticity from sex-specific relapse vulnerability.
Face-selective neural activity occurs concurrently across the human ventral occipito-temporal cortex, challenging traditional hierarchical models of visual object recognition where response latencies increase along the cortical hierarchy.
Samantha Rose Golf, Justin H Trotter ... Thomas C Südhof
Genetic deletions in mouse models and human neuron co-cultures reveal that astrocytic neuroligins are dispensable for synapse formation and maintenance of normal astrocyte morphology, suggesting neuroligins serve alternative, unidentified roles.
In-situ glial cell-surface proteomics reveals DIP-β as a glial longevity factor that enhances intercellular communication and extends lifespan in aging Drosophila.
Leiomodin 1 acts as a critical molecular switch during early muscle stem cell differentiation by sequestering the deacetylase SIRT1 in the cytoplasm to initiate the myogenic program.
