Quantitative Genetics: A Collection of Articles

Collection

1. 1. Evolutionary Biology
   2. Genetics and Genomics

   Gene expression variability in human and chimpanzee populations share common determinants

   Benjamin Jung Fair et al.

   Similar evolutionary pressures on gene expression between human and chimpanzee populations contribute to the observation that inter-individual gene expression variability is similar across genes in these species.
2. 1. Genetics and Genomics

   Rare variants contribute disproportionately to quantitative trait variation in yeast

   Joshua S Bloom et al.

   Rare, evolutionarily recent variants have larger effect sizes and are more likely to decrease fitness, providing evidence that quantitative traits in yeast have evolved under purifying selection.
3. 1. Genetics and Genomics

   Genetic and environmental perturbations lead to regulatory decoherence

   Amanda Lea et al.

   Infection and metabolic syndrome lead to a loss of molecular regulation, and changes in molecular correlations are under genetic control as revealed by the presence of correlation quantitative trait loci.
4. 1. Genetics and Genomics

   Genetic variation in adaptability and pleiotropy in budding yeast

   Elizabeth R Jerison et al.

   Substantial heritable genetic variation in adaptability and the pleiotropic consequences of adaptation exists in budding yeast, and can be explained by a combination of fitness and specific segregating alleles.
5. 1. Genetics and Genomics

   Spontaneous mutations and the origin and maintenance of quantitative genetic variation

   Wen Huang et al.

   Whole genome DNA sequence analysis, genome wide gene expression and complex organismal phenotypes in Drosophila mutation accumulation lines provide a robust estimate of the spontaneous mutation rate and mutational effects.
6. 1. Computational and Systems Biology

   Linking traits based on their shared molecular mechanisms

   Yael Oren et al.

   Systematic analysis of a broad spectrum of behavioral and physiological traits reveals novel relationships among complex traits, and resolves their underlying combination of genetic loci and molecular mechanisms.
7. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Genetic interactions affecting human gene expression identified by variance association mapping

   Andrew Anand Brown et al.

   Multiple replicated examples of epistasis affecting gene expression in humans are identified, some explaining a substantial proportion of the variation in expression.
8. 1. Evolutionary Biology
   2. Genetics and Genomics

   Reduced signal for polygenic adaptation of height in UK Biobank

   Jeremy J Berg et al.

   Many prior signals of polygenic adaptation on human height do not replicate in the UK Biobank.
9. 1. Evolutionary Biology
   2. Genetics and Genomics

   Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

   Mashaal Sohail et al.

   Polygenic selection signals in humans estimated from previously existing GWAS should be viewed with caution due to concerns about residual population stratification.
10. 1. Plant Biology

    The genetic architecture of host response reveals the importance of arbuscular mycorrhizae to maize cultivation

    M Rosario Ramírez-Flores et al.

    Heritable variation in the benefit maize plants receive from arbuscular mycorrhizal fungi supports the feasibility of breeding crops to optimize use of this ancient symbiosis.
11. 1. Ecology
    2. Plant Biology

    Natural genetic variation in Arabidopsis thaliana defense metabolism genes modulates field fitness

    Rachel Kerwin et al.

    Environmental heterogeneity may contribute to the high levels of genetic variation in glucosinolate genes found in Arabidopsis thaliana.
12. 1. Evolutionary Biology
    2. Genetics and Genomics

    Ecological adaptation in Atlantic herring is associated with large shifts in allele frequencies at hundreds of loci

    Fan Han et al.

    Hundreds of loci underlying ecological adaptation to different environmental conditions show striking differences in allele frequencies between ecotypes of Atlantic herring.
13. 1. Developmental Biology
    2. Evolutionary Biology

    An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice

    João PL Castro et al.

    Genome sequencing of mice selected for longer limbs reveals that rapid selection response is due to both discrete loci and polygenic adaptation.