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    1. Genetics and Genomics

    How dietary choice influences lifespan in fruit flies

    Giving flies a choice of foods changes the chemical messaging in their brain that is responsible for coordinating metabolism, shortening their lifespan as a result.
    1. Ecology
    2. Microbiology and Infectious Disease

    Scientists present novel approach for monitoring freshwater health

    Study describes how the world’s smallest portable DNA sequencing device helps simplify the monitoring of bacteria in freshwater ecosystems.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Formula predicts ideal dose of stem cells to cure HIV

    A model calculates ideal conditions that could make stem cell transplantation using gene editing a curative treatment for HIV.
    1. Medicine

    Scientists reveal how gut microbes can influence bone strength in mice

    New findings could aid the development of therapies that change the gut microbiome to allow healthy skeletal growth in humans.
  1. Media Coverage: December roundup of eLife papers in the news

    High-profile news coverage that eLife papers generated in December 2020, including The Times, the Daily Express and Forbes.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Scientists reveal how the immune system helps fight hantaviruses

    A study shows for the first time how antibodies can prevent hantavirus infection, with findings that may lead to new treatment and prevention strategies.
    1. Cell Biology
    2. Medicine

    New drug combination could improve glucose and weight control in diabetes

    Adding an experimental cancer drug to a widely used diabetes medicine enhances glucose management and weight control in mice.
    1. Genetics and Genomics

    Manipulating a metabolic pathway extends lifespan in fruit flies

    Scientists have identified a metabolic pathway associated with aging and mitochondrial dysfunction in fruit flies, and show that downregulation of this pathway can extend lifespan.
    1. Cell Biology

    Reducing proton leak restores function in aging heart cells

    Blocking proton leaks in mitochondria via a crucial mitochondrial transport protein can rejuvenate aging heart cells and helps reverse aging heart dysfunction.
  2. eLife supports PREreview’s new peer review mentoring program for early-career researchers

    The two initiatives are collaborating on a project by PREreview to help instruct and support early-career researchers in scholarly review.