Digital NF-κB signaling achieves orthogonal control over the probability of activation (percentage of activated cells) and dynamic response heterogeneity in the population via the area and shape of the input profile.

Pre-existing enhancers interpret T cell signaling strength in an analogue manner to direct quantitative changes in gene expression within the context of an overall digital response.

Single-cell data on cell signaling responses to nutrient variation enable quantitative models of cellular control over protein synthesis, formalizing the concept of mTOR as a homeostatic controller of cellular metabolism.

Phase-specific mechanical and proteomic analyses reveal how tendon responds to its mechanical environment during postnatal development to meet functional requirements.

Optical recordings reveal previously unknown neuromodulator dynamics in the striatum during animal movements that suggest a new interpretation of the underpinnings of bradykinetic movements exhibited in Parkinson's Disease patients.

Hyperphosphatemia, by itself and in the context of chronic kidney disease, contributes to iron restrictive anemia by directly targeting the liver and elevating proinflammatory cytokines and hepcidin, which contributes to widespread tissue injury, such as skeletal muscle wasting.

In response to neuronal activity in vivo, mitochondria in dendrites of excitatory neurons inhibit recruitment of ionotropic glutamate receptors through a reactive oxygen signaling mechanism.

In cerebellar interneurons, somatodendritic subthreshold synaptic activity travels down the axon and augments AP-dependent GABA release by a modulation of the intermediate states of voltage-dependent Ca⁺⁺ channels in the presynaptic boutons.

Cells package active receptors in endosomes at fairly constant amounts and can determine different cell-fate decisions by regulating the number and lifetime of receptor packages.

Plant meristem size and shape is controlled by two intertwined regional feedback signals that are mediated by secreted peptides.