Dopaminergic and serotonergic neurons in the dorsal raphe nucleus have distinct electrical and morphological properties, which are differentially altered following dopamine and noradrenaline depletion.
Expression of the appropriate repertoire of membrane channels, essential for activity of flight-promoting central dopaminergic neurons of Drosophila, requires store-operated Ca2+ entry during late pupal development and early adults.
LRRK plays an essential, cell-intrinsic role in the protection of dopaminergic neurons during aging, and new genetic findings suggest that LRRK2 mutations may impair its function, leading to dopaminergic neurodegeneration in PD.
Repressing astroglial PTBP1 by shRNA or antisense oligonucleotide fails to convert astrocyte to neuron including dopaminergic neuron in a 6-OHDA mouse model of PD.
Daniel J Galtieri, Chad M Estep ... D James Surmeier
Pedunculopontine neurons can evoke burst spiking in substantia nigra dopaminergic neurons without engaging a subtype of glutamate receptor previously thought to be necessary for this spiking mode.
Motivation for flight and feeding behaviour requires dopamine release which depends on cholinergic stimulation and intracellular Ca2+ release from ER stores in one or two pairs of central dopaminergic neurons.
The non-selective Na+ leak channel (NALCN) and the transient receptor potential 3 channel (TRPC3) cooperate in driving pacemaking in substantia nigra dopaminergic neurons.