174 results found
    1. Cell Biology
    2. Developmental Biology

    FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis

    Melissa Kelley, John Yochem ... David S Fay
    A fibrillin-related protein, FBN-1, is a key component of the apical extracellular matrix and prevents epidermal cell deformation by biomechanical forces during morphogenesis of the C. elegans embryo.
    1. Computational and Systems Biology
    2. Neuroscience

    Noise promotes independent control of gamma oscillations and grid firing within recurrent attractor networks

    Lukas Solanka, Mark CW van Rossum, Matthew F Nolan
    Random fluctuations in neuronal firing may enable a single brain region, the medial entorhinal cortex, to perform distinct roles in cognition (by generating gamma waves) and spatial navigation (by producing a grid cell map).
    1. Developmental Biology
    2. Genetics and Genomics

    Splicing in a single neuron is coordinately controlled by RNA binding proteins and transcription factors

    Morgan Thompson, Ryan Bixby ... Adam D Norris
    Single-cell splicing of a conserved neuronal kinase is established by a combinatorial code of fate-determining transcription factors and neuronal RNA binding proteins, with different combinations in different neuron types.
    1. Neuroscience

    Visual landmarks sharpen grid cell metric and confer context specificity to neurons of the medial entorhinal cortex

    José Antonio Pérez-Escobar, Olga Kornienko ... Kevin Allen
    The firing rate of MEC neurons conveys information about visual landmarks.
    1. Neuroscience

    During hippocampal inactivation, grid cells maintain synchrony, even when the grid pattern is lost

    Noam Almog, Gilad Tocker ... Dori Derdikman
    Grid cells lose their hexagonality during hippocampal inactivation, but maintain temporal and spatial synchrony between pairs of cells, implying that hippocampus does not determine phase relations between grid cells.
    1. Neuroscience

    Fan cells in lateral entorhinal cortex directly influence medial entorhinal cortex through synaptic connections in layer 1

    Brianna Vandrey, Jack Armstrong ... Matthew F Nolan
    A synaptic circuit through which 'what' streams of information associated with the lateral entorhinal cortex may influence 'where' streams of information associated with the medial entorhinal cortex prior to their integration in the hippocampus.
    1. Neuroscience

    Anatomical organization of presubicular head-direction circuits

    Patricia Preston-Ferrer, Stefano Coletta ... Andrea Burgalossi
    Presubicular head-direction circuits are cell-type specific, with long-range projections reaching the 'grid-cell area' medial entorhinal cortex.
    1. Neuroscience

    Functional topography of the human entorhinal cortex

    Tobias Navarro Schröder, Koen V Haak ... Christian F Doeller
    By employing high-field fMRI and taking advantage of well-known global connectivity fingerprints and sensitivity to spatial and non-spatial information, it is shown that the entorhinal cortex is primarily divided into anterior and posterior subregions.
    1. Cell Biology
    2. Neuroscience

    Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling

    Michael Krieg, Jan Stühmer ... Miriam B Goodman
    A conceptual framework and physical model shows how actin-spectrin networks and microtubule bundles can protect axons from mechanical stress.
    1. Neuroscience

    A theory of joint attractor dynamics in the hippocampus and the entorhinal cortex accounts for artificial remapping and grid cell field-to-field variability

    Haggai Agmon, Yoram Burak
    A theory of coordinated neural network dynamics in multiple brain areas offers an explanation for several recent experimental findings in the hippocampus and medial entorhinal cortex.

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