8,043 results found
    1. Neuroscience

    A prefrontal network model operating near steady and oscillatory states links spike desynchronization and synaptic deficits in schizophrenia

    David A Crowe, Andrew Willow ... Bagrat Amirikian
    Cortical network model suggests a mechanism explaining the link between NMDAR synaptic and spike synchrony deficits observed in a pharmacological monkey model of prefrontal network failure in schizophrenia.
    1. Physics of Living Systems

    Vein fate determined by flow-based but time-delayed integration of network architecture

    Sophie Marbach, Noah Ziethen ... Karen Alim
    Relative hydraulic resistance, shear rate, and pressure in a vascular network integrate the network's architecture via fluid flow, and determine vein dynamics, with a time delay, in the prototypical organism Physarum polycephalum.
    1. Epidemiology and Global Health
    2. Medicine

    Role of direct and indirect social and spatial ties in the diffusion of HIV and HCV among people who inject drugs: a cross-sectional community-based network analysis in New Delhi, India

    Steven J Clipman, Shruti H Mehta ... Sunil S Solomon
    Beyond well-recognized individual-level risk factors, HIV and hepatitis C transmission among people who inject drugs are further impacted by social and spatial network composition, and spaces in particular may represent efficient means for disseminating interventions that diffuse through the network.
    1. Neuroscience

    Metformin reverses early cortical network dysfunction and behavior changes in Huntington’s disease

    Isabelle Arnoux, Michael Willam ... Albrecht Stroh
    In a premanifest mouse model of Huntington's disease at a stage very far from disease onset, significant network and behavior dysregulation was found, being rebalanced by treatment with metformin.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Landscape of epithelial–mesenchymal plasticity as an emergent property of coordinated teams in regulatory networks

    Kishore Hari, Varun Ullanat ... Mohit Kumar Jolly
    Investigation of regulatory network topology reveals latent design principles of multistable phenotypic landscape.
    1. Cell Biology
    2. Computational and Systems Biology

    On the flexibility of the cellular amination network in E coli

    Helena Schulz-Mirbach, Alexandra Müller ... Steffen N Lindner
    The amination network for the distribution of assimilated ammonium throughout metabolism is defined by promiscuous transaminases, allowing a high flexibility of the network that supported engineering novel connections and even alternative ammonium assimilation entry points.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    β-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network

    Jennifer K Briggs, Anne Gresch ... Richard KP Benninger
    The functional network of β-cells in the pancreatic islet, which has been used to identify important subpopulations of β-cells implicated in diabetes progression, is indicative of intrinsic dynamics rather than structural communication, implying islet robustness.
    1. Computational and Systems Biology

    Gene regulatory network reconstruction using single-cell RNA sequencing of barcoded genotypes in diverse environments

    Christopher A Jackson, Dayanne M Castro ... David Gresham
    Single cell expression data can be used to determine how regulatory transcription factors and target genes are connected, and is especially useful when studying transcription factors controlling heterogeneous cell states.
    1. Cell Biology

    Quantitative mapping of keratin networks in 3D

    Reinhard Windoffer, Nicole Schwarz ... Rudolf E Leube
    Based on 3D visualization of fluorescently labeled cytoskeletal networks, an imaging platform is provided, which allows 3D network reconstruction, immersive visualization and quantification of local network properties serving as blueprints for functional modeling.
    1. Neuroscience

    Large-scale network integration in the human brain tracks temporal fluctuations in memory encoding performance

    Ruedeerat Keerativittayayut, Ryuta Aoki ... Kiyoshi Nakahara
    Graph analysis revealed that spontaneous fluctuations of episodic-memory encoding performance associate with time-varying brain connectivity networks.

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