Amy L Williams, Giulio Genovese ... Molly Przeworski
In humans, non-crossover gene conversion events transmit GC alleles in 68% of cases and exhibit a complex pattern of multiple disconnected tracts clustered within 20–30 kilobase intervals.
Erik Wijnker, Geo Velikkakam James ... Korbinian Schneeberger
A comprehensive and genome-wide description of the genomic make-up and frequency of meiotic recombination in Arabidopsis thaliana reveals regional preferences, including nucleosome-free regions, and two associated recombination motifs.
Nadine Vincenten, Lisa-Marie Kuhl ... Adèle L Marston
The meiotic DNA recombination landscape is locally influenced by the kinetochore to minimize potentially deleterious pericentromeric crossover recombination.
Fanny Janssen, Anastasios Bardoutsos ... Joop De Beer
Accounting for the impact of smoking, obesity, and alcohol on past mortality trends, we project, compared to common practice, longer individual lifespans and more elderly in society for the future.
Genome-wide mapping of heteroduplex DNA (a recombination intermediate) formed during mitotic recombination in yeast demonstrates that the "classical" model of double-strand DNA break repair is inadequate to explain several aspects of mitotic recombination.
Regina Rillo-Bohn, Renzo Adilardi ... Abby F Dernburg
Investigation of meiosis in the nematode Pristionchus pacificus has illuminated evolutionary variation in this essential aspect of reproduction and established a new model for future study.
Mathematical modelling, together with super-resolution imaging in Arabidopsis, demonstrates that a recently proposed coarsening model for meiotic crossover interference can explain the dynamic patterning of crossovers in many contexts, including in zyp1 and pch2 chromosome structure mutants.
Sara A Carioscia, Kathryn J Weaver ... Rajiv C McCoy
A computational method and genome-wide scan of low-coverage single-cell sequencing data from a large sample of human sperm suggests balanced transmission of alleles to the gamete pool.
The Srs2 helicase functions in Synthesis-Dependent Strand Annealing to avoid crossover formation during homologous recombination by disrupting D-loops that are extended by DNA polymerase delta in an ATP-dependent and direction-specific manner.
