BCL9/Legless is an integral component of the Wnt enhanceosome, harboring binding sites in its conserved C-terminus for multiple core components of this complex including ChiLS and Groucho/TLE.

Synthetic PPARγ ligands push and cobind with natural endogenous ligands, instead of compete and displace, which synergistically affects the structure and function of PPARγ.

Sorting nexin 9, a membrane curvature inducing protein, creates a distinct environment within clusters of the co-receptor CD28 and thereby allows T cell activation to proceed to a successful outcome.

Advanced microscopy techniques reveal unique biological features that distinguish androgen receptor variant 7 (AR-V7) from the canonical AR, including high intranuclear mobility and rapid nuclear import that occurs independently of importin-α/β.

Live imaging of the Notch co-activator Mastermind reveals that it promotes the formation of a dynamic transcription hub in Notch ON nuclei, conferring probabilistic transcription and providing a template for signal memory.

The ATPase Fap7 prefabricates a uS11:eS26 ribosomal protein complex for ribosome assembly.

A comprehensive analysis of the glucocorticoid-sensitive pro-inflammatory genes in macrophages reveals fundamental differences between the temporal events and components of transcriptional machinery that the glucocorticoid receptor targets to repress their transcription.

The prolactin receptor, Janus kinase 2, and PI(4,5)P₂ form a co-structure with the membrane resulting in orientations with different accessibility fixing the disordered juxtamembrane domain of the receptor in an extended structure.

Selective involvement of Arp2/3 complex subunit isoforms ARPC5 or ARPC5L governs the distinct actin polymerization events in the nucleus or cytoplasm of CD4 T cells that are triggerd by T cell activation or DNA replication stress.

In Drosophila melanogaster, nutrition controls body size by acting through the Forkhead Box class O (FoxO)/Ultraspiracle complex to regulate nutrition-sensitive ecdysone biosynthesis, thereby controlling the switch to stop growth.