The dynamic structure of respiratory complex I from mesophilic bacterium is revealed and demonstrates existence of uncoupled conformations in the bacterial complex.

The site of ubiquinone binding observed in the cryo-EM structure of respiratory complex I during turnover supports a two-state stabilization change mechanism.

A conserved mitochondrial inner membrane complex called MICOS works together with the mitochondrial lipid cardiolipin and respiratory complexes to direct the position, copy number and stabilization of cristae structures for efficient respiration.

The PreBötzinger complex, which contains neurons that are the kernel for inspiratory rhythm generation, also contains sympathoexcitatory and parasympathoinhibitory neurons that drive respiratory-phase oscillations in blood pressure and heart rate.

The localization of respiratory complexes in the cell membrane emerges as a critical factor for controlling respiration in bacteria.

The structures of plant CIII2, CIV, and SC III2+IV challenge long-standing assumptions, generate new mechanistic hypotheses and allow for the generation of more selective agricultural inhibitors.

Structures of respiratory complex I from the insect and metazoan model system Drosophila melanogaster reveal its close relationships with the mammalian complex and provide a foundation for new approaches to disentangle mechanisms of complex I catalysis and regulation.

A calcium-based mechanism of neural recruitment offers a biophysical framework that unifies recent findings on respiratory rhythm generation and pattern formation by the circuitry within the brainstem.

Opioids cause hyperpolarization and pre-synaptic suppression among a subset of preBötzinger Complex neurons to impair respiratory rhythmogenesis.

A novel toxicophore, a 1H-1,2,3-triazole, has been identified in a wide-number of therapeutically-relevant compounds, including two anti-cancer chemotherapeutics, which inhibits mitochondria function and is mechanistically linked to adverse cardiac-cell events.