SIRT2 has detrimental effects in the heart and plays a role in cardiac response to injury and the progression of cardiac hypertrophy, and targeting SIRT2 may provide a novel avenue for the treatment of cardiac hypertrophy and ischemic disease.

Sirt3 functions as decrotonylase to regulate histone crotonylation dynamics.

SIRT1 and SIRT3-mediated immunometabolic shift governs intracellular Salmonella proliferation both in vitro and in vivo and dissemination in mice, thereby influencing the infection outcomes.

SIRT1 deacetylates SIRT6 at K33 to facilitate DNA double-strand breaks-recognition, subsequent expansion and local chromatin remodeling.

Hundreds of proteins are involved in the DNA damage response but only three sensors for DSB were known but now SIRT6 is identified as a fourth DSB sensor.

The decrotonylase FoSir5 modulates ATP synthesis that supports conidial germination in Fusarium oxysporum through coordinated lysine decrotonylation in different organelles.

SIRT4 regulates cellular communication network factor 2 expression through U2 small nuclear RNA auxiliary factor 2-mediated pre-mRNA splicing, presenting a potential therapeutic target for kidney fibrosis.

A new post-translational regulatory mechanism of K-Ras is identified, which expands the function of reversible protein lysine fatty acylation and offers new possibility to target the K-Ras oncoprotein.

A series of experiments at the molecular level reveal the underlying mechanism of how a gene activates liver glucose production to regulate the blood glucose metabolism in mice.

Vitamin D bound to its receptor interacts with SIRT1 to induce its auto deacetylation and catalytic activity, which drives anti-proliferative effects in colorrectal cancer and this may lead to new therapeutic approaches for colorrectal and perhaps other cancers.