Synergistic interactions with PI(4,5)P2 and activated Rho1, which are enriched at the apical membrane of tubular organs, facilitate tight apical targeting of the formin Diaphanous.

Knocking out Folliculin (FLCN) in human renal epithelial cells activates STAT1/2-mediated gene expression, independent of interferon, uncovering a tissue-specific process potentially relevant in the cancer syndrome Birt-Hogg-Dubé (BHD).

The 3D shape and dynamic organization of epithelial cells are far more complex than previously believed, but can be explained with simple physical principles based on lateral surface energy minimisation.

Quantitative analysis in quasi-3D reveals apically driven cell behaviours that are closely coordinated across the tissue to allow ordered tube invagination through a focal point.

PSTPIP2 reduced IL-19 secretion by inhibiting activation of the NF-κB pathway in renal tubular epithelial cells (RTECs), reducing the generation of neutrophil extracellular trap, which can participate in both aristolochic acid I-induced renal injury and apoptosis in RTECs.

A rare example of direct transdifferentiation is discovered in zebrafish in which kidney epithelial cells change into an endocrine gland and undergo live-cell extrusion from the renal tubule.

Purinergic signaling controls mammalian sperm transport.

Monounsaturated fatty acids protect against DKD by enhancing membrane fluidity and decreasing ER lipid bilayer stress in renal proximal tubules.

Single-cell RNA-sequencing identifies the precise cellular and molecular events that occur along the sepsis timeline in the kidney, pointing to potential biomarkers and therapeutic targets.

Kidney organoids are a high-fidelity system for investigating basement membrane regulation in development and disease.