Andrew R Bassett, Asifa Akhtar ... Chris P Ponting
We discuss the methods available to understand lncRNA function in vivo, and highlight important considerations that should be taken into account when designing such experiments.
Andrew M Stern, Arturo Casadevall ... Ferric C Fang
In the first study attempting to formally quantify the deleterious impact of research misconduct on funding sources and publication output, we found that misconduct accounts for a small but substantial portion of American biomedical science funding dollars and damages the productivity and rate of funding acquisition of those who commit misconduct.
eLife has introduced a new type of article–the Research Advance–that allows the authors of an eLife paper to publish results that build on their original research paper.
In this episode we hear about using photographs to diagnose rare genetic disorders, an unexpected benefit of exercise, hybridizing fish species, Rett syndrome, and using gene drives to eradicate disease.
Kevin M Esvelt, Andrea L Smidler ... George M Church
Combining CRISPR/Cas9 genome editing with gene drives may enable scientists to reversibly edit the genomes of diverse wild populations, an advance that could help eliminate diseases, support sustainable agriculture, and control invasive species.
