Numerous pathways/function predictions were identified via gene sets, phosphopeptides, and phosphoproteins, which may point to potential novel therapeutic targets to enhance heart adaptivity, maintaining heart performance while avoiding cardiac dysfunction.

In a mouse model of neurofibromatosis type 1, the purinergic receptor P2RY14 is a key regulator of Schwann cell precursor self-renewal and proliferation, of neurofibroma tumor initiation and of mouse survival.

The reward signal dopamine modulates synaptic plasticity by increasing protein synthesis, revealing a potential molecular mechanism for long-term memory storage.

Spermatozoa require GIV for specialized compartmentalized signaling to support efficient capacitation while inhibiting premature acrosome reaction.