High-resolution maps and models of the bacterial ribosome provide new chemical insights into protein synthesis, and should enable the development of robust tools for cryo-EM structure modeling and refinement.
Alexa Pichet Binette, Guillaume Theaud ... PREVENT-AD Research Group
White matter microstructure alterations in key bundles affected in Alzheimer's disease are related to amyloid and tau pathology in the preclinical phase of sporadic and autosomal-dominant Alzheimer's disease.
Elizabeth Griggs, Kyle Trageser ... Giulio Maria Pasinetti
New evidence of brain proinflammatory cascades supports post-acute sequelae of SARS-CoV-2 infection, ultimately promoting the onset and progression of Alzheimer's disease as a function of age.
Analysis of the osteochondral unit of aquatic mammals reveals a distinctly different tissue structure, lacking the arcade-like collagen fiber organization, a calcified cartilage layer and a dense subchondral bone plate, typically seen in osteochondral tissue of terrestrial mammals.
David AD Munro, Yishay Wineberg ... Jamie A Davies
Embryonic macrophages encourage early kidney development, interact with developing renal blood vessels, are enriched for mRNAs linked to vascular development, and promote endothelial cross-connections.
Diane M Bushman, Gwendolyn E Kaeser ... Jerold Chun
Somatically derived genomic mosaicism in the form of increased DNA content and APP copy number in single neurons plausibly has a function in sporadic Alzheimer’s disease and points to functions for single-neuron gene copy number changes.
Nadine Vincenten, Lisa-Marie Kuhl ... Adèle L Marston
The meiotic DNA recombination landscape is locally influenced by the kinetochore to minimize potentially deleterious pericentromeric crossover recombination.
Adrian L Sanborn, Benjamin T Yeh ... Roger D Kornberg
Transcriptional activation domains achieve rapid, dynamic, specific interaction with Mediator through binding of an unstructured peptide to multiple hydrophobic surfaces without particular amino acid side chain interactions.
Kiwamu Kudo, Kamalini G Ranasinghe ... Srikantan S Nagarajan
Event-based sequencing models for Alzheimer’s disease progression revealed that abnormal neural synchrony occurs during the earliest preclinical stages of the disease, preceding brain atrophy and cognitive decline.
While tau and aging have highly overlapping differential gene expression signatures, they diverge in the affected cell types, with aging having a wide-ranging impact and tau-triggered changes instead polarized to excitatory neurons and glia.
