1,031 results found
    1. Neuroscience

    CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons

    Margherita Farina, Rhea van de Bospoort ... Ruud F Toonen
    Stationary dense-core vesicles depend on the CAPS-1 protein to fuse with the presynaptic membrane.
    1. Cell Biology
    2. Developmental Biology

    Rediscovering the rete ovarii, a secreting auxiliary structure to the ovary

    Dilara N Anbarci, Jennifer McKey ... Blanche Capel
    The rete ovarii is a complex secretory structure that may play an important role in ovarian homeostasis.
    1. Genetics and Genomics

    Dysfunction of Calcyphosine-Like gene impairs retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy

    Wenjing Liu, Shujin Li ... Xianjun Zhu
    Genetic analysis and knockout mouse model study identified calcyphosine-like (CAPSL) as a candidate disease gene in familial exudative vitreoretinopathy (FEVR), offering valuable insights into disease mechanisms.
    1. Developmental Biology

    Integration of mouse ovary morphogenesis with developmental dynamics of the oviduct, ovarian ligaments, and rete ovarii

    Jennifer McKey, Dilara N Anbarci ... Blanche Capel
    A detailed characterization of mouse ovary development using tissue clearing and 3D lightsheet imaging identifies ovary folding, specification of cortical and medullary domains, and ovary encapsulation as major hallmarks of ovary morphogenesis.
    1. Developmental Biology

    Neural tube-associated boundary caps are a major source of mural cells in the skin

    Gaspard Gerschenfeld, Fanny Coulpier ... Piotr Topilko
    Neural tube-associated boundary caps are heterogeneous with a non-neural crest-derived subpopulation that may originate from the developing meninges, which gives rise to derivatives that migrate along nerves to detach and differentiate into skin mural cells.
    1. Biochemistry and Chemical Biology

    A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters

    Pattama Wiriyasermkul, Satomi Moriyama ... Shushi Nagamori
    An unbiased approach unveils a non-canonical substrate of the known transporters, highlighting the mechanism behind the use of D-serine as a kidney biomarker.
    1. Ecology
    2. Neuroscience

    Dopamine drives Drosophila sechellia adaptation to its toxic host

    Sofía Lavista-Llanos, Aleš Svatoš ... Bill S Hansson
    The insect dopaminergic system serves an important function in the regulation of ontogenesis and early development, contributing to the evolutionary processes that limit the ecological niche of Drosophila sechellia.
    1. Cell Biology
    2. Neuroscience

    Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

    Alexander M Walter, Rainer Müller ... Jakob Balslev Sørensen
    Increasing PI(4,5)P2 on a sub-second timescale using a novel, membrane-permeant UV activatable PI(4,5)P2 molecule augments exocytosis which requires the PI(4,5)P2 interacting exocytotic proteins Munc13-2 and synaptotagmin-1.
    1. Microbiology and Infectious Disease

    Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis

    Mehak Zahoor Khan, Debbie M Hunt ... Vinay Kumar Nandicoori
    CysM and CysK2 play complementary and overlapping roles in Mtb's adaptation to environmental stress that are crucial for survival.

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