A novel B cell receptor induced interleukin 10 (IL-10) production from B10 cells involves signal transducer and activator of transcription 5 (STAT5) mediated IL-6 production which induces IL-10 in an autocrine and paracrine fashion from B10 cells.
A new perception of the organization of T-cell receptor repertoires in mice and humans, based on high-throughput sequencing and CDR3 sequence similarity, indicates hubs of cross-species public sequences forming evolutionary conserved 'foci of attention' of T cell immunity.
Targeting CD73 not only enhances anti-tumor immunity but also disrupts tumor cell metabolism and hinders poly ADP ribose polymerase (PARP) activity, thus unveiling novel opportunities for combination cancer treatments.
The B-1a cell heavy chain antibody repertoire differs dramatically from the follicular and marginal zone B cell repertoire and is defined by distinct mechanisms driven by self antigens rather than antigens derived from the microbiota.
Michael Jonathan Lehrke, Michael Jeremy Shapiro ... Virginia Smith Shapiro
In the absence of ABCB7, B cell development is halted at the pro-B cell stage and stimulated splenic B cells have impaired proliferation and reduced class switch recombination.
Damián Pérez-Mazliah, Peter J Gardner ... Jean Langhorne
Plasmodium-specific atypical memory B cells generated to naturally (mosquito) transmitted rodent malaria infection are short-lived activated B cells, and do not prevent resolution of infection or generation of long-lived memory.
Carlos Castrillon, Lea Simoni ... Michael C Carroll
In an autoimmune environment B cells mature from spontaneous germinal centers into transcriptomically and phenotypically diverse memory and antibody-secreting cells but maintaining shared clonal and potential self-reactive specificities which has important implications for pathogenic cell targeted depletion.
The T cell repertoire can display immunodominance to an epitope as a result of optimal positive selection in the thymus by one self-peptide/MHC ligand.
