769 results found
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort

    Oliver Robinson, ChungHo E Lau ... Martine Vrijheid
    Among European children, shorter telomere length and older DNA methylation age relative to chronological age were associated with poorer behaviors, while older age, as predicted by a novel immunometabolic clock relative to chronological age, was associated with greater cognitive maturity.
    1. Epidemiology and Global Health

    Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019)

    Marina Padilha, Victor Nahuel Keller ... Gilberto Kac
    A panel of serum biomarkers, including dietary and microbial-derived metabolites related to the gut-brain axis, were identified as potential for tracking children at risk of early childhood developmental delays.
    1. Neuroscience

    Sleep spindle maturity promotes slow oscillation-spindle coupling across child and adolescent development

    Ann-Kathrin Joechner, Michael A Hahn ... Markus Werkle-Bergner
    Across four samples of children, adolescents, and young adults, age-related higher similarity of dominant, development-specific fast sleep spindles and adult-like fast sleep spindles is uniquely related to stronger and more precise slow oscillation-sleep spindle coupling.
    1. Neuroscience

    Novelty and uncertainty differentially drive exploration across development

    Kate Nussenbaum, Rebecca E Martin ... Catherine A Hartley
    From middle childhood to early adulthood, the preference to engage with novel choice options remained consistent, but aversion to reward uncertainty increased.
    1. Genetics and Genomics
    2. Neuroscience

    Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy

    Timothy J Abreo, Emma C Thompson ... Edward C Cooper
    A single amino acid change in a neuronal ion channel called KCNQ2 blocks ion flow, prevents protein localization on axons, and results in severe epilepsy and slowed neurological development.
    1. Computational and Systems Biology
    2. Medicine

    The vaginal immunoproteome for the prediction of spontaneous preterm birth: A retrospective longitudinal study

    Zachary Shaffer, Roberto Romero ... Nardhy Gomez-Lopez
    The vaginal immunoproteome in pregnancy is more predictive of spontaneous preterm birth (sPTB) than maternal characteristics alone, with sPTB cases showing heightened pro-inflammatory profiles accompanied by reduced levels of antimicrobial proteins/peptides.
    1. Neuroscience

    Specific lexico-semantic predictions are associated with unique spatial and temporal patterns of neural activity

    Lin Wang, Gina Kuperberg, Ole Jensen
    The prediction of specific words is associated with distinct spatial and temporal patterns of neural activity within the left inferior and medial temporal regions before the predicted word is presented.
    1. Neuroscience

    Science Forum: What is next in African neuroscience?

    Kirsten A Donald, Mahmoud Maina ... Charles R Newton
    Working in Africa provides neuroscientists with opportunities that are not available in other continents, but obstacles must be overcome for the neuroscience community in Africa to reach its full potential.
    1. Developmental Biology

    Single nuclei RNA-seq of mouse placental labyrinth development

    Bryan Marsh, Robert Blelloch
    A time-course of single nuclei RNA-seq of the mouse placenta identifies trophoblast subtypes and the genes, signaling events, and transcriptional networks important for their differentiation, maintenance, and function.
    1. Developmental Biology
    2. Neuroscience

    Fetal influence on the human brain through the lifespan

    Kristine B Walhovd, Stine K Krogsrud ... Didac Vidal-Pineiro
    Greater early developmental growth, as indexed by birth weight, relates to greater cortical volume and area in a stable way through the human lifespan.

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