255 results found
    1. Developmental Biology
    2. Immunology and Inflammation

    Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice

    Ken-ichi Hirano, Akiko Suganami ... Katsuto Hozumi
    Notch ligand, Dll4 needs the flexible loop structure in the MNNL domain of the extracellular region to efficiently trigger the Notch signaling.
    1. Cell Biology

    Ubiquitylation-independent activation of Notch signalling by Delta

    Nicole Berndt, Ekaterina Seib ... Thomas Klein
    Analysis of a variant without lysine in the intracellular domain reveals a ubiquitylation-independent signalling activity of the DSL ligand Delta and novel functions of the Neuralized and Mindbomb1 E3-ligases during Notch signalling.
    1. Cell Biology
    2. Developmental Biology

    Myoblast cytonemes mediate Wg signaling from the wing imaginal disc and Delta-Notch signaling to the air sac primordium

    Hai Huang, Thomas B Kornberg
    Cytonemes mediate, and are essential for, Wingless signaling from the Drosophila wing disc to disc-associated myoblasts and for Delta-Notch signaling from these myoblasts to the dorsal air sac primordium.
    1. Developmental Biology

    Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation

    Maria R Stupnikov, Ying Yang ... Wellington V Cardoso
    Notch ligands from the Delta and Jagged families have distinct roles in epithelial progenitor cell fate of extrapulmonary and intrapulmonary airways and differentially restrict expansion of the neuroendocrine microenvironment.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

    Shogo Sawaguchi, Shweta Varshney ... Tetsuya Okajima
    The transfer of O-GlcNAc by EOGT to specific EGF repeats of NOTCH1 promotes DLL4 binding, Notch signaling, and retinal vascular development.
    1. Computational and Systems Biology
    2. Developmental Biology

    Diversity in Notch ligand-receptor signaling interactions

    Rachael Kuintzle, Leah A Santat, Michael B Elowitz
    The Notch signaling pathway can use its various ligands, receptors, and Fringe proteins to generate diverse intra- and intercellular signaling behaviors.
    1. Developmental Biology
    2. Neuroscience

    Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches

    Branden R Nelson, Rebecca D Hodge ... Robert F Hevner
    Multiphoton live-imaging illuminates the dynamic underpinnings of how different types of progenitor cells migrate and interact to robustly build the mammalian Dentate Gyrus neural circuitry and new outer neurogenic niche.
    1. Developmental Biology

    The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro

    Lena Tveriakhina, Karin Schuster-Gossler ... Achim Gossler
    Regions outside the major receptor binding interface of DLL1 and DLL4 contribute to context-dependent divergence of ligand function in vivo and differential Notch1 and Notch2 activation in vitro.
    1. Developmental Biology

    Delta-dependent Notch activation closes the early neuroblast temporal program to promote lineage progression and neurogenesis termination in Drosophila

    Chhavi Sood, Md Ausrafuggaman Nahid ... Sarah E Siegrist
    Notch signaling regulates the neuroblast intrinsic temporal program to determine when neuroblasts terminate their cell divisions during development.
    1. Developmental Biology
    2. Evolutionary Biology

    Long-distance communication by specialized cellular projections during pigment pattern development and evolution

    Dae Seok Eom, Emily J Bain ... David M Parichy
    Cells of the xanthophore lineage form projections that allow them to communicate with other pigment cells during adult pigment pattern formation in zebrafish, but not in the closely-related pearl danio.

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