Sphinganine-1-phosphate (SA1P) is linked to paclitaxel-induced peripheral neuropathy, offering a potential target for reducing this severe side effect of paclitaxel treatment.

Single-cell RNA-sequencing unraveled cell subtype-specific transcriptomic changes in both injured and uninjured primary sensory neurons after nerve injury and demonstrated transcriptomic sexual dimorphism.

Stimulation of the rate-limiting enzyme in the NAD salvage pathway protected against neurotoxicity and subsequent peripheral neuropathy associated with the widely utilized anticancer drug, paclitaxel.

A comprehensive compendium of myelin proteins in the peripheral nervous system has been created, alongside a method to address molecular diversity of myelin sheaths in health and disease.

Single-nuclear transcriptomic profiling and functional assays identified PKR activation and mitochondrial dysfunction in HIV-associated nephropathy mice kidneys.

Operant drug self-administration in a mouse model of neuropathic pain reveals pain-relieving effects of a cannabinoid CB₂ receptor agonist that are mediated through CB₂ receptors of neurons and lymphocytes.

Selectively eliminating resident astrocytes in lumbar enlargement attenuated neuropathic pain associated with type I interferons (IFNs) signal activation in microglia.

No single molecular change is uniquely necessary to cause neuropathic changes in primary afferent excitability; multiple different changes are sufficient.

Local deep hypothermia combined with hibernation-mimicking cold protection is neuroprotective in a translatable large animal model of traumatic optic neuropathy.

The complement pathway can contribute to corneal sensation loss and nerve damage during ocular surface inflammation.