34 results found
    1. Cancer Biology
    2. Cell Biology

    ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor

    Zineb Mounir et al.
    The transcription factor ERG recruits the PRMT5 enzyme to methylate the androgen receptor, presenting a post-translational regulatory mechanism that could be therapeutically exploited to control cell proliferation.
    1. Biochemistry and Chemical Biology

    Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing

    Li Zhang et al.
    Inhibiting PRMT1 enzymatic activity promotes megakaryocyte terminal differentiation via RBM15-mediated RNA metabolism, which is dysregulated in hematological malignancies.
    1. Cancer Biology
    2. Cell Biology

    Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling

    Yingqi Liu et al.
    PRMT7-mediated SHANK2 methylation regulates breast cancer metastasis by activating endosomal FAK signals, and may provide potential clues for tumour metastasis treatment strategies.
    1. Neuroscience

    Protein arginine methylation facilitates KCNQ channel-PIP2 interaction leading to seizure suppression

    Hyun-Ji Kim et al.
    The PRMT1 protein mediates arginine methylation of KCNQ2 channels to control neuronal excitability.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

    Palaniraja Thandapani et al.
    Arginine methylation regulates mRNA translation of key protooncogenes via an RGG/RG motif-containing protein called Aven.
    1. Biochemistry and Chemical Biology

    A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

    Xiao-Chuan Cai et al.
    A chemical probe was characterized for potency, selectivity, and ability to alter CARM1-dependent epigenetic plasticity against cancer cell invasion.
    1. Stem Cells and Regenerative Medicine

    Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians

    Jordi Solana et al.
    A conserved alternative splicing program is specific to planarian stem cells and is controlled by the highly conserved splicing factors CELF and MBNL; therefore, this mode of regulating stem cells is likely ancestral to all animals.
    1. Cell Biology
    2. Neuroscience

    Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development

    Maryam Izadi et al.
    Extended biochemical and functional analyses in primary neurons show that early neuronal morphogenesis critically relies on cooperation of the actin nucleator Cobl and its ancestor Cobl-like and uncover their cooperative mechanisms at dendritic branch initiation sites.

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