Combining experiments, bioinformatics, and mathematical modelling, we find large heterogeneity in naive T cell clone sizes.

Longitudinal tracking of individual T-cell clones reveals the expansion of pre-existing T-cell memory in response to SARS-CoV-2 infection.

The rapid development of immune memory in infancy shapes the composition of T cell defenses throughout the human lifespan.

An analysis of T cell receptor occurrence patterns that accounts for MHC restriction reveals striking imprints of common viral pathogens and patterns of TCR-HLA sequence covariation in a large human cohort.

The integration of pHLA binding and pHLA-TCR analysis effectively improves the precision of insilico neoantigen prioritization, potentially enhancing personalized immunotherapies for colorectal cancer.

Digitalized TCR repertoire-based view on antigenic specificity, plasticity, and tissue residence of regulatory T cells.

A new perception of the organization of T-cell receptor repertoires in mice and humans, based on high-throughput sequencing and CDR3 sequence similarity, indicates hubs of cross-species public sequences forming evolutionary conserved 'foci of attention' of T cell immunity.

Distance-based TCR analysis enables grouping of biochemically similar clonotypes into meta-clonotypes that have increased publicity, and therefore statistical power, for population-level detection of antigen-specific T cells in infection and vaccination.

The SLAM/SAP signaling pathway regulates both γδ T cell developmental programming and γδ/αβ T cell lineage commitment.

Deep learning improves estimation of T cell receptor cohort frequencies and learns the rules of VDJ recombination, potentially making it helpful for vaccine design.