Ezrin controls endo-lysosomal signaling by maintaining TSC inhibition through EGFR signaling, activating mTORC1, and inhibiting lysosomal function, unveiling a critical endosome–lysosome network essential for autophagy and cellular homeostasis.

Upon PDGFRα signaling in mouse embryonic palatal mesenchyme cells, Srsf3 exhibits differential transcript binding, resulting in retention of the receptor in early endosomes and increased downstream PI3K-mediated Akt signaling.

PRMT7-mediated SHANK2 methylation regulates breast cancer metastasis by activating endosomal FAK signals, and may provide potential clues for tumour metastasis treatment strategies.

Cell biological approaches and spatiotemporally resolved proteome profiling demonstrate that the chemokine receptor CCR7 can activate G proteins after being internalized into endosomes, from where it regulates Rac1-dependent chemotaxis.

Engineering cytokines to exhibit different receptor binding dwell times is a useful strategy to decouple their functional pleiotropy and reduce their toxicity in the clinic.

Different dynorphins, which signal similarly from the cell surface, can differentially localize G protein-coupled receptors to specific subcellular compartments and cause divergent receptor fates and distinct spatiotemporal patterns of signaling.

The vasopressin type 2 receptor promotes dual Gα_s and Gα_q/11 signaling at early endosomes in β-arrestin-dependent and -independent manners.

Genetic and biochemical approaches identify a new component of the cellular signaling machinery driving migration of limb muscle precursor cells during mouse embryogenesis and reveal the underlying molecular mechanism.

A screen encompassing all kinases and phosphatases reveals that PI3K-cII, PI3K-cIII and Rab11-dependent recycling endosomes comprise a novel, postsynaptic 'signaling controller' that is part of an integrated, trans-synaptic signaling system necessary for presynaptic homeostatic plasticity.