683 results found
    1. Genetics and Genomics

    Using adopted individuals to partition indirect maternal genetic effects into prenatal and postnatal effects on offspring phenotypes

    Liang-Dar Hwang, Gunn-Helen Moen, David M Evans
    Adopted individuals in large-scale population based cohorts can be leveraged to partition maternal genetic effects into prenatal and postnatal components, helping elucidate the underlying mechanisms behind these associations, and for diseases, yielding important information regarding the optimal timing of interventions.
    1. Evolutionary Biology

    Decoupled maternal and zygotic genetic effects shape the evolution of development

    Christina Zakas, Jennifer M Deutscher ... Matthew V Rockman
    Early development involves both maternal and zygotic genetic effects. This dual genetic basis shapes the evolution of developmental mode in a marine annelid.
    1. Genetics and Genomics

    Genetic variation in offspring indirectly influences the quality of maternal behaviour in mice

    David George Ashbrook, Beatrice Gini, Reinmar Hager
    A cross-fostered population of mice reveals loci on offspring chromosomes 5 and 7 that modify the behaviour of their mothers, along with evidence of coadaptation between offspring and parental traits.
    1. Developmental Biology
    2. Genetics and Genomics

    Constraint and divergence of global gene expression in the mammalian embryo

    Noah Spies, Cheryl L Smith ... Arend Sidow
    Embryonic gene expression is strongly influenced by maternal genetic variation and by embryonic variation that acts in cis but not in trans.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study

    Amanda M Hughes, Eleanor Sanderson ... Neil M Davies
    It is unclear how much a child's BMI at age 8 affects their depressive and ADHD symptoms after family-level factors are accounted for, but a substantial impact on anxiety symptoms is unlikely.
    1. Chromosomes and Gene Expression

    Differential methylation between ethnic sub-groups reflects the effect of genetic ancestry and environmental exposures

    Joshua M Galanter, Christopher R Gignoux ... Noah Zaitlen
    An epigenome-wide study shows that ethnic self-identification and genetically determined ancestry both make important independent contributions to DNA methylation levels.
    1. Cancer Biology
    2. Cell Biology

    MELK is not necessary for the proliferation of basal-like breast cancer cells

    Hai-Tsang Huang, Hyuk-Soo Seo ... Nathanael S Gray
    The inhibitory or deletion effect of MELK does not impair the proliferation of basal-like breast cancer cell lines.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Selfing is the safest sex for Caenorhabditis tropicalis

    Luke M Noble, John Yuen ... Matthew V Rockman
    Out breeding depression in Caenorhabditis tropicalis is due to common maternal-offspring incompatibilities that interact with a highly heterogeneous genetic background and may provide a short-term advantage to inbreeding.
    1. Ecology
    2. Genetics and Genomics

    Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure

    Samuel E Champer, Isabel K Kim ... Jackson Champer
    Continuous space models indicate that current homing suppression drives may have difficulty eliminating wild mosquito populations, but building a successful drive may still be possible with current tools.
    1. Developmental Biology

    Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally

    Jadiel A Wasson, Ashley K Simon ... David J Katz
    Epigenetic reprogramming by LSD1/KDM1A acts at fertilization in mice to enable embryogenesis and prevent behavioural abnormalities.

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