The termination of medulla neuroblasts is specified by the depletion of the neuroepithelium and mediated by apoptosis, differentiation, and gliogenic switch.
Cell-cycle-dependent Notch signaling cooperates with temporal transcription factors to promote the progression of the temporal transcription factor cascade in Drosophila medulla neuroblasts.
The Notch signaling pathway has a central role in the development of the nervous system, and also in the establishment of networks of connections in the adult brain
David J Jörg, Elizabeth E Caygill ... Benjamin D Simons
A model of signalling pathways interacting with proneural gene expression explains the sequential patterning of the largest visual processing centre in the developing Drosophila brain.
A zebrafish model of neuroblastoma reveals that the tumor suppressor NF1 uses different mechanisms to suppress malignant transformation and to down-modulate normal neural crest cell growth during embryogenesis.
Structural brain plasticity is encoded in the topographic distribution of Toll receptors and their ability to switch between alternative signalling outcomes, thus translating diverse sensory experience into structural change.
Easy-to-use image analysis software enables single cell quantitation of cell types and division rates in complex 3D tissues including living Drosophila brains, mouse embryos and Zebrafish organoids.