7 results found
    1. Genetics and Genomics

    Environmentally-induced epigenetic conversion of a piRNA cluster

    Karine Casier, Valérie Delmarre ... Antoine Boivin
    Activation of a piRNA cluster is achieved by high temperature and without maternal inheritance of homologous piRNAs highlighting how variations of species natural habitat can become heritable and shape epigenome.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A spontaneous genetically induced epiallele at a retrotransposon shapes host genome function

    Tessa M Bertozzi, Nozomi Takahashi ... Anne C Ferguson-Smith
    A retrotransposon-derived recombination event in inbred mice gives rise to an epiallele and tissue-specific phenotypes.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Environmentally sensitive hotspots in the methylome of the early human embryo

    Matt J Silver, Ayden Saffari ... Andrew M Prentice
    259 CpGs associated with season of conception in rural Gambians constitute a valuable resource for investigating epigenetic mechanisms linking early exposures to lifelong health and disease.
    1. Chromosomes and Gene Expression

    Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse

    Luke Isbel, Lexie Prokopuk ... Emma Whitelaw
    Though generally considered a transcriptional repressor, Wiz may also function as a transcriptional activator in the mouse brain and is required for normal behaviour.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Leveraging the Mendelian disorders of the epigenetic machinery to systematically map functional epigenetic variation

    Teresa Romeo Luperchio, Leandros Boukas ... Hans T Bjornsson
    Chromatin/transcriptome profiling in multiple mouse models with mutations in epigenetic machinery (EM) reveals shared abnormalities including many IgA-relevant genes, indicating that this kind of joint analysis may elucidate the multigenic nature of EM disorders.
    1. Genetics and Genomics

    Sequence features of retrotransposons allow for epigenetic variability

    Kevin R Costello, Amy Leung ... Dustin E Schones
    Variably methylated retrotransposons have an underlying sequence that allows them to escape KAP1-mediated silencing and recruit ZF-CxxC proteins.
    1. Chromosomes and Gene Expression

    NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins

    Amy E Campbell, Sean C Shadle ... Stephen J Tapscott
    CRISPR/Cas9 engineered locus-specific proteomics leads to the identification of NuRD, CAF-1, and MBD3L2 as regulators of the early embryonic transcription factor DUX4.

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