Onsite sanitation maybe insufficient to interrupt transmission of enteric infections in high-burden urban settings, though risk of some infections may be reduced among children protected from birth.

Parasitic helminths infect over a billion humans and use unusual anaerobic metabolism that needs a rare electron carrier, Rhodoquinone (RQ), whose synthesis requires the kynurenine pathway of tryptophan degradation.

The switch from ubiquinone to rhodoquinone synthesis that is required for parasitic helminths to survive in anaerobic host tissues is due to alternative splicing of polyprenyltransferase COQ-2.

Comparative phylogenomic analyses based on a new reference-quality human Ascaris genome assembly reveals a pig/human interbred species complex with implications for Ascaris control worldwide.

In a randomized controlled trial in rural Bangladesh, an intensive, combined water, sanitation, handwashing, and nutrition intervention delivered to compounds of newborn children increased telomere length attrition during their first year of life.

An analysis of national survey data shows that vitamin A might protect against malaria infection, an effect potentially modified by seasonality, and that no routine vaccinations were linked to parasitemia, though BCG vaccination was associated with PfHRP-2 antigenemia.

Scale-up of safe water supplies decreases a child's risk of urogenital schistosomiasis infection by eight-fold in a typical rural African population.

Given sufficient population adherence, mass drug administration for falciparum malaria can provide group level benefits, also known as ‘herd effects’.

Regulation of a nuclear receptor signaling pathway may cure the often-lethal disease caused by the endemic parasitic roundworm, Strongyloides stercoralis.

High-resolution risk estimates of opisthorchiasis were produced in major endemic countries of Southeast Asia, providing valuable information for guiding disease control and serving as a baseline for future progress assessment.