6,260 results found
    1. Neuroscience

    Direct observation of the neural computations underlying a single decision

    Natalie Steinemann, Gabriel M Stine ... Michael N Shadlen
    Simultaneous recording from many neurons in macaque lateral intraparietal area reveals the elusive drift-diffusion signal, long suspected to underlie individual perceptual decisions and response times.
    1. Cell Biology
    2. Neuroscience

    Retinoic acid-induced protein 14 controls dendritic spine dynamics associated with depressive-like behaviors

    Soo Jeong Kim, Youngsik Woo ... Sang Ki Park
    Rai14-Tara complex enhances the stability of dendritic spines and synaptic connections relevant to depressive-like behaviors.
    1. Neuroscience

    The actin-modulating protein synaptopodin mediates long-term survival of dendritic spines

    Kenrick Yap, Alexander Drakew ... Thomas Deller
    Long-term imaging of dentate granule cells reveals that the presence of synaptopodin within large spines, rather than their size, conveys long-term stability to large spines.
    1. Ecology
    2. Evolutionary Biology

    Old age variably impacts chimpanzee engagement and efficiency in stone tool use

    Elliot Howard-Spink, Tetsuro Matsuzawa ... Dora Biro
    Long-term standardized data collection on wild western chimpanzees reveals late-life changes in stone tool use, and the extent of these changes varies between individuals.
    1. Neuroscience

    Electrical and Ca2+ signaling in dendritic spines of substantia nigra dopaminergic neurons

    Travis A Hage, Yujie Sun, Zayd M Khaliq
    Dopaminergic cells uniquely receive input from a roughly equal mixture of synapses on dendritic spines and synapses formed directly on dendrites.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Origins of the 2009 H1N1 influenza pandemic in swine in Mexico

    Ignacio Mena, Martha I Nelson ... Adolfo García-Sastre
    Genome sequence data from 58 Mexican swine influenza A viruses resolves the spatial origin of the virus that originated the influenza pandemic of 2009.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The global antigenic diversity of swine influenza A viruses

    Nicola S Lewis, Colin A Russell ... Amy L Vincent
    Swine populations worldwide are sporadically infected by influenza viruses from humans and birds leading to geographically heterogeneous swine influenza virus populations that pose epizootic and pandemic threats.
    1. Cell Biology
    2. Developmental Biology

    Notochord vacuoles absorb compressive bone growth during zebrafish spine formation

    Jennifer Bagwell, James Norman ... Michel Bagnat
    Live imaging and genetic analyses revealed that notochord vacuoles play a critical role in spine morphogenesis by absorbing vertebral bone growth, thus implicating notochord mechanics in congenital scoliosis.
    1. Neuroscience

    Microglial motility is modulated by neuronal activity and correlates with dendritic spine plasticity in the hippocampus of awake mice

    Felix Christopher Nebeling, Stefanie Poll ... Martin Fuhrmann
    Microglia that presumably sense neuronal activity via detection of glutamate at synapses in the hippocampus show higher fine process motility and increased contact rates associated with formation and elimination of dendritic spines under conditions of elevated neuronal activity.
    1. Neuroscience

    Frequency- and spike-timing-dependent mitochondrial Ca2+ signaling regulates the metabolic rate and synaptic efficacy in cortical neurons

    Ohad Stoler, Alexandra Stavsky ... Ilya Fleidervish
    Optical recordings from L5 cortical pyramidal neurons expressing mitochondria-targeted Ca2+ indicator, mitoGCaMP6m, reveal compartment-specific mitochondrial responses to spike firing and synaptic activity.

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