Cryo-EM structures and molecular dynamics simulations of Cx43 gap junction channel and hemichannel reveal a putative closed state.

The functional network of β-cells in the pancreatic islet, which has been used to identify important subpopulations of β-cells implicated in diabetes progression, is indicative of intrinsic dynamics rather than structural communication, implying islet robustness.

A combination of molecular dynamics simulations and X-ray diffraction data has been used to construct more realistic models of proteins and to provide new insights into their interactions with other proteins and biomolecules.

The crystal structure of human Holliday junction resolvase GEN1 in complex with DNA reveals a conserved chromodomain as an additional DNA-anchoring point that opens new perspectives for enzyme regulation.

Ultrastructural analysis of optogenetically stimulated inner hair cell ribbon synapses reveals normally sized synaptic vesicles and enhanced vesicle docking at the active zone membrane.

An optimal wire and function trade-off emerges from noisy growth and stochastic retraction during Drosophila class I ventral posterior dendritic arborisation (c1vpda) dendrite development.

Structure, dynamics, and mutation of a gamete fusion protein and comparisons to viral homologues suggest that after trimerization the domain bearing the membrane-inserting fusion loops can pivot with respect to the trimer 3-fold axis.

Differing from its ortholog in Helicoverpa armigera, pheromone receptor HassOr14b is tuned to the major sex pheromone component in H. assulta, and two amino acids in the intracellular domain determine their ligand selectivity.

Multi-modal structural data fusion questions the specificity of fMRI-behavior associations by providing strong evidence relating human brain structure to a wide range of behavioral measures previously associated to functional connectivity.

Electron microcopy-based connectomics, in vivo functional imaging, and biophysical modeling reveal that mouse visual cortex chandelier cells, a type of GABAergic interneuron, are driven by arousal and distribute their synapses according to the individual properties of target cells.