858 results found
    1. Genetics and Genomics
    2. Neuroscience

    The structure of behavioral variation within a genotype

    Zachary Werkhoven, Alyssa Bravin ... Benjamin L de Bivort
    Multidimensional analysis of data from high-throughput behavioral assays reveals many independent axes of behavioral variation among inbred animals reared in the same environment.
    1. Neuroscience

    Comprehensive machine learning analysis of Hydra behavior reveals a stable basal behavioral repertoire

    Shuting Han, Ekaterina Taralova ... Rafael Yuste
    A novel automated behavior analysis method for Hydra identifies pre-defined and new behavior types, and reveals a stable behavior repertoire.
    1. Computational and Systems Biology

    Unsupervised machine learning reveals risk stratifying glioblastoma tumor cells

    Nalin Leelatian, Justine Sinnaeve ... Jonathan M Irish
    A new automated and unsupervised algorithm, Risk Assessment Population IDentification, identifies risk-stratifying cells in single cell datasets with robust statistical and biological validation.
    1. Structural Biology and Molecular Biophysics

    Top-down machine learning approach for high-throughput single-molecule analysis

    David S White, Marcel P Goldschen-Ohm ... Baron Chanda
    A new analysis algorithm (DISC) enables accurate analysis of data from high-throughput single-molecule paradigms and reveals a non-cooperative binding mechanism of cyclic nucleotide-binding domains from HCN ion channels.
    1. Computational and Systems Biology

    Multicellular factor analysis of single-cell data for a tissue-centric understanding of disease

    Ricardo Omar Ramirez Flores, Jan David Lanzer ... Julio Saez-Rodriguez
    A computational framework allows the unsupervised analysis of samples from single cell data across conditions, inference of multicellular programs associated with disease, and meta-analysis of independent patient cohorts.
    1. Computational and Systems Biology

    Trajectories of childhood immune development and respiratory health relevant to asthma and allergy

    Howard HF Tang, Shu Mei Teo ... Michael Inouye
    Unsupervised cluster analysis identified similar groups of children in different cohorts, with distinct developmental patterns of immunorespiratory health, asthma and allergy.
    1. Cell Biology
    2. Computational and Systems Biology

    Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins

    Alex X Lu, Yolanda T Chong ... Alan M Moses
    100,000s of images from different growth conditions and genetic backgrounds can be integrated into proteome-scale analysis.
    1. Cell Biology

    Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations

    Linda K Krasniewski, Papiya Chakraborty ... Myriam Gorospe
    Single-cell analysis of skeletal mouse reveals highly diverse macrophage subgroups associated with diverse functions and age-related changes.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy

    Sierra M Barone, Alberta GA Paul ... Jonathan M Irish
    Rare, virus-specific immune cells in human blood are automatically identified by machine learning algorithm T-REX and characterized for signature features needed for tracking and isolation.
    1. Neuroscience

    Unsupervised learning of haptic material properties

    Anna Metzger, Matteo Toscani
    Perceptual haptic representation of materials emerges from unsupervised learning as a consequence of efficient encoding of the physical signals at the input of tactile sensory system.

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