Bikash Adhikari, Katharina Schneider ... Elmar Wolf
A rapamycin-induced proximity assay enables rapid identification of optimal E3 ligases for target protein degradation in living cells, streamlining early-stage proteolysis targeting chimera development.
Structure-based designed chalcone and pyrazoline derivatives inhibited the ELF3-MED23 protein-protein interaction, leading to HER2 downregulation and retardation of tumor growth in HER2-positive gastric cancer.
The minimal twister sister (TS)-like self-cleaving ribozymes, revealed by deep mutational scanning, represent some of the very few human/primate ribozymes.
Clara Bekirian, Isabel Valsecchi ... Thierry Fontaine
β-1,6-Glucan is crucial for Candida albicans cell wall structure and integrity, adapting dynamically to environmental stresses and compensating for mannan deficiencies in cell wall organization.
A folding-function model for the guanidine-IV riboswitch under both guanidine-free and guanidine-present conditions offers valuable insights into its regulatory mechanism.
Marius Landau, Sherif Elsabbagh ... Joachim E Schultz
The dodecahelical membrane anchors of mammalian adenylyl cyclase isoforms are receptors for unsaturated free fatty acids and, as a tonic signal, enhance or attenuate GPCR/Gsα-stimulated cyclic AMP formation.
