Browse our latest Biochemistry and Chemical Biology articles

Equilibrium and nonequilibrium simulations uncover how the fatty acid site in the SARS-CoV-2 spike modulates protein dynamics, revealing its intricate allosteric connections and the impact of glycans on these networks.

Mapping the functional landscape of >6600 MC4R variants via deep mutational scanning reveals novel determinants of biased signaling and ligand interactions that inform targeted obesity therapeutics.

The DRAM system enables antibody-free, bisulfite-free, and transcriptome-wide mapping of 5-methylcytosine in mRNA with high accuracy, stability, and sensitivity, even at ultralow RNA inputs.

Pseudomonas putida coordinates chemotaxis and resistance to copper through the interaction between CheA and CsoR.

Adenosine produced by transmethylation may act as a sensor of the balance between cell activity and nutrient supply.

This enzymatic method enables highly specific and complete 1:1 protein conjugations with small molecules, solid supports, and other proteins, offering broad applicability across diverse biochemical and biotechnological applications.

CROWN-seq provides the first precise and quantitative map of N⁶,2’-O-dimethyladenosine (m⁶Am) in mRNA and snRNA, revealing the link between m⁶Am modification and efficient transcription, rather than translation and RNA stability.

A camelid single-domain antibody potently and specifically inhibits pyruvate kinases from trypanosomatids.

The central nitrogen-metabolite 2-oxoglutarate directly promotes glutamine synthetase activity by inducing its dodecameric assembly and priming the active sites, representing a novel mechanism of regulation.