Stefanie SM Meier, Michael Hörzing ... Andreas Möglich
Custom-tailored bathy-phytochromes control bacterial gene expression by near-infrared light while exhibiting minimal response to red light, thus unlocking innovative application scenarios.
Omar Herrera-Asmat, Alexander B Tong ... Carlos Bustamante
Optical tweezers are used to gain mechanistic insight in the mechanism of inhibition of three distinct compounds being developed as antibiotics against Mycobacterium tuberculosis.
Muscle-derived branched-chain amino acids support thermogenesis in brown adipose tissue, thereby helping maintain body temperature during impaired muscle function or physiological stress.
Steven P Maher, Malina A Bakowski ... Dennis E Kyle
Drug repurposing screens reveal several epigenetic inhibitors as active against P. vivax hypnozoites demonstrating that epigenetic pathways play a central role in hypnozoite quiescence.
Elena G Govorunova, Oleg A Sineshchekov ... John L Spudich
Ancyromonad channelrhodopsins advance understanding of ionic selectivity and wavelength regulation in light-gated ion channels, and expand the toolkit for multiplexing with red-shifted fluorescent sensors.
Lipid binding stabilizes the SARS-CoV-2 Orf9b homodimer, slowing its conversion to the Tom70-binding monomeric form and modulating interferon suppression.
