Browse our latest Biochemistry and Chemical Biology articles

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    1. Biochemistry and Chemical Biology

    The intrinsically disordered N-terminus of SUMO1 is an intramolecular inhibitor of SUMO1 interactions

    Sebastian M Richter, Fan Jin ... Frauke Melchior
    Revised
    Reviewed Preprint v2
    Updated
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    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    The deubiquitinase Ubp3/Usp10 constrains glucose-mediated mitochondrial repression via phosphate budgeting

    Vineeth Vengayil, Shreyas Niphadkar ... Sunil Laxman
    A primary constraint for mitochondrial repression is access to cytosolic inorganic phosphate, which is determined by the glycolytic flux rate.
    1. Biochemistry and Chemical Biology

    Immunotherapy: The power lies in the glycans

    Luca Unione, Jesús Jiménez-Barbero
    Glycans play an important role in modulating the interactions between natural killer cells and antibodies to fight pathogens and harmful cells.
    Version of Record
    Insight
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins

    Kristina Ehring, Sophia Friederike Ehlers ... Kay Grobe
    A composite hedgehog release model that incorporates and supports a previously disparate set of observations has been presented.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Structure and evolution of alanine/serine decarboxylases and the engineering of theanine production

    Hao Wang, Biying Zhu ... Zhaoliang Zhang
    Comparative structural analysis and biochemical characterization unraveled the mechanisms behind enzymatic substrate selectivity, leading to an amplified theanine yield through active mutant protein screening, thus refining strategies for theanine production.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Point of View: Teaching troubleshooting skills to graduate students

    Gina Partipilo, Yang Gao ... Benjamin K Keitz
    Pipettes and Problem Solving is an initiative that teaches some of the skills needed to figure out why an experiment is producing unexpected results.
    1. Biochemistry and Chemical Biology

    Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation

    Tristan A Bell, Bridget E Luce ... Luke H Chao
    Prominin 1 and Tweety Homology 1, two proteins that regulate membrane shape in neural and neuroepithelial cells, have shared evolutionary history and both cause cells to secrete extracellular vesicles.
    1. Biochemistry and Chemical Biology

    Syntaxin-6 delays prion protein fibril formation and prolongs the presence of toxic aggregation intermediates

    Daljit Sangar, Elizabeth Hill ... Jan Bieschke
    A new native prion protein aggregation assay shows that syntaxin-6, a risk factor for sporadic Creutzfeldt–Jakob disease, delays prion protein fibril formation and prolongs the presence of toxic aggregation intermediates.
    1. Biochemistry and Chemical Biology

    Quantitative mapping of proteasome interactomes and substrates using ProteasomeID

    Aleksandar Bartolome, Julia C Heiby ... Alessandro Ori
    Proximity labeling combined with mass spectrometry enables to map the proteasome proximal proteome in cells and mouse tissues.