Browse our latest Biochemistry and Chemical Biology articles

The cryptic pocket is critical for one of the VP35 protein's functions and therefore is likely under selective pressure.

Environmental chloride ions act as essential counterions that enable coral opsins to respond to visible light, and the polar residue Glu292 plays a critical role in chloride binding.

Peptide inhibitors of E3 ubiquitin ligase anaphase-promoting complex/cyclosome, engineered for enhanced affinity by incorporating unnatural amino acids, are able to block substrate ubiquitination and drive degradation of a fused target.

The target of quinofumelin is DHODH in the de novo pyrimidine biosynthesis pathway.

A single hydrophobic interaction drives allosteric gate-opening of the archaeal 20S proteasome, identifying a specific new target for therapeutic drug design.

A phage-displayed synthetic library and screening platform offer a streamlined, cost-effective solution for nanobody discovery.

Elevated ubiquitin phosphorylation disrupts proteasomal function, creating a self-amplifying cycle that drives progressive protein aggregation and neuronal injury across multiple neurodegenerative conditions.

A modular DNA barcoding strategy enables efficient multiplexed protein detection for both in situ imaging and high-throughput molecular diagnostics.

A comprehensive resource describes protein abundance and phosphorylation dynamics during Xenopus oocyte maturation, serving as an essential tool for investigating the molecular mechanisms driving meiotic progression.