Browse our latest Biochemistry and Chemical Biology articles

Customized AlphaFold-based modeling of distinct functional states of the hERG channel, a major drug anti-target, significantly improves drug affinity predictions, enhancing cardiac safety screening for arrhythmia risk.

An analytical approach increases spatiotemporal resolution, optimizes real-time, in vivo detection of Met- and Leu-enkephalin, and provides novel insight into the relationship between Met- and Leu-enkephalin following stress.

SHAPE-MaP reveals functional RNA structures in the porcine epidemic diarrhea virus genome, enabling targeted siRNA design and offering a promising strategy to inhibit viral replication.

Although eIF2A is thought to be a translation initiation factor, loss of eIF2A has no effect on cellular mRNA translation in either unstressed or stressed conditions.

A strategy that analyzes the structural properties of RNA could help identify regions that are promising targets for antiviral drugs.

Autocatalytic dual specificity of kinase IKK2/β, a Serine/Threonine kinase, is important for its substrate phosphorylation activity through an uncommon phosphorelay mechanism.

Regulation of mitochondrial DNA copy number is highly tissue-specific and context-dependent, particularly in the presence of disease.

Proteomics with PP1-Neurabin fusion proteins identify the 4E-BP proteins as novel Neurabin/PP1 substrates, and interaction with the Neurabin PDZ domain shown to be the major determinant of Neurabin/PP1 substrate specificity.

A high-throughput chemical screen identifies ligands of the Kelch domain of E3 ligase KLHDC2 capable of being modified as proteolysis-targeting chimeras.