Browse our latest Biochemistry and Chemical Biology articles

The microenvironment within biomolecular condensates exhibits interfacial behaviors characterized by a combination of hydrophobic and hydrophilic properties.

Targeting two novel sites on the hepatitis B virus capsid disrupts its assembly and induces aggregation, suggesting potential for antiviral therapy development.

Molecular, biophysical, and computational analysis reveals insights on the mechanism of association of birnavirus VP3 with endosomes and its role in the viral life cycle, representing a substantial contribution toward understanding the replication strategy of these 'non-canonical' viruses.

In the bacterium M. smegmatis, an enzyme called MftG allows the cofactor mycofactocin to transfer electrons released during ethanol metabolism to the electron transport chain.

A combination of polymer physics theories consistently rationalizes comprehensive experimental effects of salt, ATP, phosphorylation, and sequence charge and arginine/lysine patterns on the reentrant phase behaviors of intrinsically disordered proteins.

Computational modeling and in vitro experiments identify a unique conformational state in amyloidogenic light chains, providing a structural basis for amyloidosis and a precise target for drug design.

The buildup of knot-like RNA structures in brain cells may be the key to understanding how uncontrolled protein aggregation drives Alzheimer’s disease.