Browse our latest Biochemistry and Chemical Biology articles

Mapping the functional landscape of >6600 MC4R variants via deep mutational scanning reveals novel determinants of biased signaling and ligand interactions that inform targeted obesity therapeutics.

Pseudomonas putida coordinates chemotaxis and resistance to copper through the interaction between CheA and CsoR.

The DRAM system enables antibody-free, bisulfite-free, and transcriptome-wide mapping of 5-methylcytosine in mRNA with high accuracy, stability, and sensitivity, even at ultralow RNA inputs.

Adenosine produced by transmethylation may act as a sensor of the balance between cell activity and nutrient supply.

This enzymatic method enables highly specific and complete 1:1 protein conjugations with small molecules, solid supports, and other proteins, offering broad applicability across diverse biochemical and biotechnological applications.

The central nitrogen-metabolite 2-oxoglutarate directly promotes glutamine synthetase activity by inducing its dodecameric assembly and priming the active sites, representing a novel mechanism of regulation.

A camelid single-domain antibody potently and specifically inhibits pyruvate kinases from trypanosomatids.

CROWN-seq provides the first precise and quantitative map of N⁶,2’-O-dimethyladenosine (m⁶Am) in mRNA and snRNA, revealing the link between m⁶Am modification and efficient transcription, rather than translation and RNA stability.

Targeting two novel sites on the hepatitis B virus capsid disrupts its assembly and induces aggregation, suggesting potential for antiviral therapy development.