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The clinically approved BTK kinase active site inhibitors alter the conformational equilibrium of full-length BTK in distinct and unexpected ways.

The Parkinson’s protein Leucine-Rich Repeat Kinase 2 contains a GTPase as well as kinase domain and modulates its intrinsic GTPase activity by autophosphorylation of the P-loop residue threonine 1343.

The Saccharomyces cerevisiae spliceosome component Fyv6 contributes to precursor messenger RNA splicing by promoting use of branch site distal 3' splice sites and interacting with key factors involved in exon ligation.

TIM23 core deficiency specifically impacts the oxidative phosphorylation and the mitochondrial ribosome complexes and, unexpectedly, leads to reduction of plasma membrane voltage-dependent potassium channels in neurons.

Plasmodium parasites have repurposed the heme oxygenase scaffold from its canonical heme-degrading function to fulfill an essential and adaptive role in gene expression within the apicoplast organelle.

Biochemical detection of endogenous, paralog-specific DVL2 complexes, molecular characterization of underlying protein domains and functional evidence for their importance extend the knowledge of Wnt pathway regulation through DVL2 biomolecular condensates.