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    1. Biochemistry and Chemical Biology

    Deep learning reveals endogenous sterols as allosteric modulators of the GPCR–Gα interface

    Sanjay Kumar Mohanty, Aayushi Mittal ... Gaurav Ahuja
    An AI-driven computational toolkit, Gcoupler, integrates ligand design, statistical modeling, and graph neural networks to predict endogenous metabolites that allosterically modulate the GPCR–Gα interface and regulate downstream signaling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

    Samantha J Cassell, Weiyan Li ... Jonathan R Whicher
    Cryo-EM and electrophysiology reveal the mechanism of SK2 channel modulation by the bee toxin apamin and small molecules, providing insights that enable the rational design of targeted SK2 channel therapeutics.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ATP-independent phosphate recycling on AGC kinase activation loops induced by alkali metal ions

    Koji Kubouchi, Hideyuki Mukai
    Not revised
    Reviewed Preprint v1
    • Incomplete
    1. Biochemistry and Chemical Biology

    MCAK recognizes the nucleotide-dependent feature at growing microtubule ends

    Wei Chen, Yin-Long Song ... Xin Liang
    A key finding is that MCAK binds to the proximal region of GTP cap where GDP‧Pi-tubulins accumulate, in addition to curved protofilaments at the distalmost tip.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: How one nutrient controls cell size

    Angela Montero, Lydia WS Finley
    The metabolic fate of a nutrient called pyruvate determines how big cells become.
    Version of Record
    Insight
    1. Biochemistry and Chemical Biology

    Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

    Yasuhiro Shinkai, Yunjie Ding ... Yoshito Kumagai
    The hold-and-release regulation of zinc by GIF/MT-3 is mediated by sulfane sulfur through a redox-dependent switching mechanism.
    1. Biochemistry and Chemical Biology

    Membrane-mimetic thermal proteome profiling (MM-TPP) toward mapping membrane protein–ligand dynamic interactions

    Rupinder Singh Jandu, Ashim Bhattacharya ... Franck Duong van Hoa
    Peptidisc-based thermal proteome profiling enables detergent-free mapping of membrane protein–ligand interactions, advancing the discovery of druggable targets in membrane-mimetic environments.
    1. Biochemistry and Chemical Biology
    2. Medicine

    NAD+ boosting by oral nicotinamide mononucleotide administration regulates key metabolic and immune pathways through SIRT1 dependent and independent mechanisms to mitigate diet-induced obesity and dyslipidemia in mice

    Yasser Majeed, Najeeb M Halabi ... Nayef A Mazloum
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method

    Soumajit Dutta, Diwakar Shukla
    New psychoactive substances activate cannabinoid receptors using distinct ligand-receptor interactions.
    1. Biochemistry and Chemical Biology

    Insight into the bioactivity and action mode of betulin, a candidate aphicide from plant metabolite, against aphids

    Junxiu Wang, Matthana Klakong ... Hong Zhou
    The insecticidal activity of betulin, a plant-derived metabolite, against the peach aphid depends on specific targeting and inhibition of MpGABR.
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