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Page 10 of 168
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Hyperglycemia induced cathepsin L maturation linked to diabetic comorbidities and COVID-19 mortality

    Qiong He, Miao-Miao Zhao ... Jin-Kui Yang
    High glucose levels promote CTSL maturation and translocation from the endoplasmic reticulum to the lysosome via the ER-Golgi-lysosome axis.
    1. Biochemistry and Chemical Biology

    Probing PAC1 receptor activation across species with an engineered sensor

    Reto B Cola, Salome N Niethammer ... Tommaso Patriarchi
    A new genetically encoded sensor robustly detects exogenously applied PAC1R ligands in vitro, ex vivo, and in vivo (in zebrafishes and mice) serving as a useful resource for probing PAC1R functions.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

    Kira Cozzolino, Lynn Sanford ... Dylan J Taatjes
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Observing one-divalent-metal-ion-dependent and histidine-promoted His-Me family I-PpoI nuclease catalysis in crystallo

    Caleb Chang, Grace Zhou, Yang Gao
    In crystallo observation of HNH family I-PpoI nuclease cleaving DNA suggests that one divalent metal ion and a histidine are required for catalysis.
    1. Biochemistry and Chemical Biology

    Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation

    Tristan A Bell, Bridget E Luce ... Luke H Chao
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The glycoprotein quality control factor Malectin promotes coronavirus replication and viral protein biogenesis

    Jonathan P Davies, Lars Plate
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Brown Adipose Tissue and Skeletal Muscle Coordinately Contribute to Thermogenesis in Mice

    Yuna Izumi-Mishima, Rie Tsutsumi ... Hiroshi Sakaue
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The ORP9-ORP11 dimer promotes sphingomyelin synthesis

    Birol Cabukusta, Shalom Borst Pauwels ... Jacques Neefjes
    Lipid transfer proteins at the ER-Golgi interface synchronize intracellular lipid flows through the secretory pathway, ensuring the asymmetric lipid composition of the plasma membrane.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Deciphering the actin structure-dependent preferential cooperative binding of cofilin

    Kien Xuan Ngo, Huong T Vu ... Taro Uyeda
    HS-AFM and Principal Component Analysis provide experimental evidence to substantiate the 'proof of principle' regarding the flexible helical twists of actin filaments that regulate the functions of actin-binding proteins.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Inhibition of mitochondrial protein import and proteostasis by a pro-apoptotic lipid

    Josep Fita-Torró, José Luis Garrido-Huarte ... Markus Proft
    Revised
    Reviewed Preprint v2
    Updated
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