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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis

    Marie Shimogawa, Ming-Hao Li ... E James Petersson
    Not revised
    Reviewed Preprint v1
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    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Identification and classification of ion-channels across the tree of life provide functional insights into understudied CALHM channels

    Rahil Taujale, Sung Jin Park ... Natarajan Kannan
    Revised
    Reviewed Preprint v2
    Updated
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    1. Biochemistry and Chemical Biology

    Profiling of terminating ribosomes reveals translational control at stop codons

    Longfei Jia, Yuanhui Mao ... Shu-Bing Qian
    Not revised
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    1. Biochemistry and Chemical Biology

    Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

    Yasuhiro Shinkai, Yunjie Ding ... Yoshito Kumagai
    The hold-and-release regulation of zinc by GIF/MT-3 is mediated by sulfane sulfur through a redox-dependent switching mechanism.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2 and -3

    Crystal R Noell, Tzu-Chen Ma ... William O Hancock
    Not revised
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    1. Biochemistry and Chemical Biology

    Membrane-mimetic thermal proteome profiling (MM-TPP) toward mapping membrane protein–ligand dynamic interactions

    Rupinder Singh Jandu, Ashim Bhattacharya ... Franck Duong van Hoa
    Peptidisc-based thermal proteome profiling enables detergent-free mapping of membrane protein–ligand interactions, advancing the discovery of druggable targets in membrane-mimetic environments.
    1. Biochemistry and Chemical Biology
    2. Medicine

    NAD+ boosting by oral nicotinamide mononucleotide administration regulates key metabolic and immune pathways through SIRT1 dependent and independent mechanisms to mitigate diet-induced obesity and dyslipidemia in mice

    Yasser Majeed, Najeeb M Halabi ... Nayef A Mazloum
    Not revised
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    1. Biochemistry and Chemical Biology

    Integrated Respirometry and Metabolomics Unveil Circadian Metabolic Dynamics in Drosophila

    Farheen Akhtar, Dania Malik ... Aalim M Weljie
    Not revised
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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method

    Soumajit Dutta, Diwakar Shukla
    New psychoactive substances activate cannabinoid receptors using distinct ligand-receptor interactions.
    1. Biochemistry and Chemical Biology

    Insight into the bioactivity and action mode of betulin, a candidate aphicide from plant metabolite, against aphids

    Junxiu Wang, Matthana Klakong ... Hong Zhou
    The insecticidal activity of betulin, a plant-derived metabolite, against the peach aphid depends on specific targeting and inhibition of MpGABR.
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