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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

    Raji E. Joseph, Thomas E. Wales ... Amy H. Andreotti
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens

    Veronica Teresa Ober, George Boniface Githure ... Michael Boshart
    A minimal subset of two to three residues in cyclic nucleotide binding (CNB) domains controls nucleoside vs. cyclic nucleotide specificity, repurposing PKA of certain pathogens for novel nucleoside signaling pathways or sensing.
    1. Biochemistry and Chemical Biology

    Structural mechanisms for VMAT2 inhibition by tetrabenazine

    Michael P Dalton, Mary Hongying Cheng ... Jonathan A Coleman
    The structure of the vesicular monoamine transporter 2 bound to Huntington’s chorea drug tetrabenazine elucidates mechanisms of inhibition and neurotransmitter transport.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Assembly of neuron- and radial glial-cell-derived extracellular matrix molecules promotes radial migration of developing cortical neurons

    Ayumu Mubuchi, Mina Takechi ... Shinji Miyata
    The extracellular matrix formed during embryonic brain development facilitates the migration of cortical neurons.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single-molecule Ligand Response of Guanidine-IV riboswitch

    Lingzhi Gao, Dian Chen, Yu Liu
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease

    Kejia Zhang, Patrick Eldin ... Dragony Fu
    1. Biochemistry and Chemical Biology

    Bacterial exonuclease III expands its enzymatic activities on single-stranded DNA

    Hao Wang, Chen Ye ... Yan Li
    1. Biochemistry and Chemical Biology

    SUMO’s intrinsically disordered N-terminus is an intramolecular inhibitor of SUMO - SIM interactions

    Sebastian M. Richter, Fan Jin ... Frauke Melchior
    1. Biochemistry and Chemical Biology

    Balanced Interplay Between Hsp110, Hsp70 and Class B J-Domain Protein Improves Aggregate Disassembly

    Wiktoria Sztangierska, Hubert Wyszkowski ... Agnieszka Kłosowska
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    X-Ray Structure and enzymatic study of a Bacterial NADPH oxidase highlight the activation mechanism of eukaryotic NOX

    Isabelle Petit-Härtlein, Annelise Vermot ... Franck Fieschi
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