Browse our latest Biochemistry and Chemical Biology articles

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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Axin scaffold protects the kinase GSK3β from cross-pathway inhibition

    Maire Gavagan, Noel Jameson, Jesse G Zalatan
    A biochemical approach using the Wnt pathway as a model system demonstrates a new mechanism for specificity in interconnected signaling networks through scaffold-mediated shielding of bound proteins.
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    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Evolution towards simplicity in bacterial small heat shock protein system

    Piotr Karaś, Klaudia Kochanowicz ... Krzysztof Liberek
    1. Biochemistry and Chemical Biology

    Saccharomyces cerevisiae DJ-1 paralogs maintain genome integrity through glycation repair of nucleic acids and proteins

    Gautam Susarla, Priyanka Kataria ... Patrick D'Silva
    Yeast DJ-1 homologs are molecular erasers of glycation adducts on cellular macromolecules and preserve mitochondrial health through redistributing into mitochondria under elevated carbonyl stress.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Investigating the composition and recruitment of the mycobacterial ImuA′–ImuB–DnaE2 mutasome

    Sophia Gessner, Zela Alexandria-Mae Martin ... Digby F Warner
    The interaction of ImuB with the β sliding clamp is essential for induced mutagenesis in mycobacteria and could be a novel target for new anti-tuberculosis drugs designed to inhibit the emergence of genetic resistance.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The intrinsically disordered cytoplasmic tail of a dendrite branching receptor uses two distinct mechanisms to regulate the actin cytoskeleton

    Daniel A Kramer, Heidy Y Narvaez-Ortiz ... Baoyu Chen
    The dendrite branching receptor HPO-30 modulates actin dynamics by binding to both WAVE complex and actin filaments.
    1. Biochemistry and Chemical Biology

    Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity

    Chandramohan Chitraju, Alexander W. Fischer ... Robert V. Farese
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    p38γ and p38δ modulate innate immune response by regulating MEF2D activation

    Alejandra Escós, Ester Diaz-Mora ... Ana Cuenda
    Generation and validation of a new mouse strain as a tool to demonstrate the implication of p38γ/p38δ in inflammation through the regulation of the transcription factor MEF2D’s activity.