Browse our latest Biochemistry and Chemical Biology articles

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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Harnessing AlphaFold to reveal hERG channel conformational state secrets

    Khoa Ngo, Pei-Chi Yang ... Igor Vorobyov
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A general mechanism for initiating the bacterial general stress response

    Rishika Baral, Kristin Ho ... Niels Bradshaw
    A coiled-coil-based transduction mechanism is identified for a serine/threonine phosphatase that controls a bacterial stress response, suggesting that phosphatases are part of a modularly exchangeable toolkit for bacterial signaling.
    1. Biochemistry and Chemical Biology

    A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins

    Daniel J Kelpsch, Liyun Zhang ... Steven A Farber
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    Daptomycin forms a stable complex with phosphatidylglycerol for selective uptake to bacterial membrane

    Pragyansree Machhua, Vignesh Gopalakrishnan Unnithan ... Zhihong Guo
    The drug-phospholipid interaction is fully elucidated at molecular level as an important part of the mode of action of daptomycin and the mechanism of its resistance in bacterial pathogens.
    1. Biochemistry and Chemical Biology

    Deep Learning Reveals Endogenous Sterols as Allosteric Modulators of the GPCR-Gα Interface

    Sanjay Kumar Mohanty, Aayushi Mittal ... Gaurav Ahuja
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Inhibition of mitochondrial protein import and proteostasis by a pro-apoptotic lipid

    Josep Fita-Torró, José Luis Garrido-Huarte ... Markus Proft
    The pro-apoptotic lipid trans-2-hexadecenal impairs mitochondrial protein import and proteostasis by targeting the TOM complex.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Synonymous mutations in AAV Rep enhance genome packaging in a library selection

    Tasfia Azim, Dru Myerscough, Jonathan J Silberg
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology

    Gut Microbe-Derived Trimethylamine Shapes Circadian Rhythms Through the Host Receptor TAAR5

    Kala K Mahen, William J Massey ... J Mark Brown
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    Membrane curvature regulates Ups1 dependent phosphatidic acid transfer across lipid bilayers

    Fereshteh Sadeqi, Dexin Dong ... Michael Meinecke
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing