Browse our latest Biochemistry and Chemical Biology articles

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    1. Biochemistry and Chemical Biology

    Disintegration promotes protospacer integration by the Cas1-Cas2 complex

    Chien-Hui Ma et al.
    Disintegration, regarded as an abortive side reaction antithetical to DNA transposition, can promote protospacer integration at the CRISPR locus via DNA repair pathways.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation

    Bence Hajdusits et al.
    The McsB kinase is critical for protein quality control in Gram-positive bacteria, assembling a gated phosphorylation chamber during heat-shock conditions to selectively mark misfolded proteins for degradation.
    1. Biochemistry and Chemical Biology

    Tissue-specific targeting of DNA nanodevices in a multicellular living organism

    Kasturi Chakraborty et al.
    DNA nanodevices can be targeted to specific cell types in Caenorhabditis elegans with subcellular precision by exploiting either endogenous or synthetic receptors.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Processing of the ribosomal ubiquitin-like fusion protein FUBI-eS30/FAU is required for 40S maturation and depends on USP36

    Jasmin van den Heuvel et al.
    Endoproteolytic cleavage of the ribosomal precursor protein FUBI-eS30 is required for efficient maturation of small ribosomal subunits in the cytoplasm of human cells and involves the nucleolar deubiquitinase USP36.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function

    Fiona Haward et al.
    A mouse model where the splicing factor SRSF1 was prevented from accumulating in the cytoplasm revealed reduced translation of thousands of mRNAs and postnatal phenotypes particularly affecting multiciliated cells.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin

    Ben C Tilly et al.
    Visualization of BRM remodelers engaging their endogenous genomic targets revealed highly transient and dynamic interactions with chromatin, which are fueled by ATP-hydrolysis.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Autoregulatory control of microtubule binding in doublecortin-like kinase 1

    Regina L Agulto et al.
    Doublecortin-like kinase 1 modulates its own kinase activity to tune its microtubule-binding affinity, providing molecular insights into a unique form of autoregulatory control over microtubule-binding activity.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants

    Tatiana P Soares da Costa et al.
    Proof-of-principle for a new herbicide mode of action through the identification of novel inhibitors of lysine biosynthesis with in planta efficacy.
    1. Biochemistry and Chemical Biology

    Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication

    Knut H Lauritzen et al.
    Transgenic mice and cell models provide evidence of a pathophysiological mechanism that connects mtDNA damage to cardiac dysfunction via reduced NAD+ levels and loss of mitochondrial function and communication.