A biochemical approach using the Wnt pathway as a model system demonstrates a new mechanism for specificity in interconnected signaling networks through scaffold-mediated shielding of bound proteins.
Gautam Susarla, Priyanka Kataria ... Patrick D'Silva
Yeast DJ-1 homologs are molecular erasers of glycation adducts on cellular macromolecules and preserve mitochondrial health through redistributing into mitochondria under elevated carbonyl stress.
Sophia Gessner, Zela Alexandria-Mae Martin ... Digby F Warner
The interaction of ImuB with the β sliding clamp is essential for induced mutagenesis in mycobacteria and could be a novel target for new anti-tuberculosis drugs designed to inhibit the emergence of genetic resistance.
Generation and validation of a new mouse strain as a tool to demonstrate the implication of p38γ/p38δ in inflammation through the regulation of the transcription factor MEF2D’s activity.
