Inhibiting the mitochondrial bc1-complex disrupts energy production in mature Toxoplasma gondii bradyzoites, suggesting a metabolic vulnerability in the parasite's chronic, drug-resistant stage.
Malaria parasites have evolved a noncanonical function for the apicoplast acyl carrier protein in stabilizing pyruvate kinase II, a metabolic hub essential for isoprenoid synthesis and parasite survival.
A streamlined seven-component cell-free expression platform simplifies reaction design while maintaining high productivity and enabling robust synthesis of challenging proteins for diverse applications.
Squidly enables efficient identification of enzyme catalytic residues by integrating functional hierarchies into a contrastive learning framework, requiring only protein sequences to produce scalable predictions across the known enzyme landscape.
