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    1. Biochemistry and Chemical Biology

    The Listeria monocytogenes persistence factor ClpL is a potent stand-alone disaggregase

    Valentin Bohl, Nele Merret Hollmann ... Axel Mogk
    The bacterial AAA+ chaperone ClpL recognizes aggregated proteins via multiple contacts of its unique N-terminal domain and refolds them with high efficiency providing superior heat resistance.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase dependent mechanism

    Bernd K. Gilsbach, Franz Y. Ho ... Christian Johannes Gloeckner
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Interplay between charge distribution and DNA in shaping HP1 paralog phase separation and localization

    Tien M Phan, Young C Kim ... Jeetain Mittal
    Despite highly conserved sequences, subtle variations in HP1 paralog charge distribution influence distinct liquid-liquid phase separation behaviors, ultimately impacting DNA-mediated heterochromatin organization.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Activity modulation in anaerobic ribonucleotide reductases: nucleotide binding to the ATP-cone allosterically mediates substrate binding to the active site

    Ornella Bimaï, Ipsita Banerjee ... Derek T. Logan
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    DePARylation is critical for S phase progression and cell survival

    Litong Nie, Chao Wang ... Junjie Chen
    DePARylation is essential for cell survival and thus poly(ADP-ribose) glycohydrolase (PARG) expression correlates with cytotoxicity induced by PARG inhibition, which will benefit the development of PARG inhibitors for cancer treatment.
    1. Biochemistry and Chemical Biology

    Mapping the molecular motions of 5-HT3 serotonin-gated channel by Voltage-Clamp Fluorometry

    Laurie Peverini, Sophie Shi ... Pierre-Jean Corringer
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    C. elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA

    Claudia D. Consalvo, Adedeji M. Aderounmu ... Brenda L. Bass
    1. Biochemistry and Chemical Biology

    Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors

    Damien M. Rasmussen, Manny M. Semonis ... Nicholas M. Levinson
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Water-soluble 4-(dimethylaminomethyl)heliomycin exerts greater antitumor effects than parental heliomycin by targeting the tNOX-SIRT1 axis and apoptosis in oral cancer cells

    Atikul Islam, Yu-Chun Chang ... Pin Ju Chueh
    Multifaceted properties of the water-soluble derivative of antibiotic heliomycin enable it to offer greater antitumor value than its parent compound by inhibiting the tNOX-NAD+-SIRT1 axis to induce apoptosis.
    1. Biochemistry and Chemical Biology

    #GotGlycans: Role of N343 Glycosylation on the SARS-CoV-2 S RBD Structure and Co-Receptor Binding Across Variants of Concern

    Callum M. Ives, Linh Nguyen ... Elisa Fadda
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