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    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genome-wide synthetic lethality screen of Bam complex-associated genes in Escherichia coli

    Jack A Bryant, Kara A Staunton ... Manuel Banzhaf
    High-throughput genetics reveals all synthetic-lethal relationships for outer membrane protein biogenesis associated genes in Escherichia coli.
    1. Biochemistry and Chemical Biology

    A Sequential Assembly Mechanism for Stable Cdc13 Dimerization on Telomeric DNA

    Po-Wei Chiu, Yu-Ting Lin ... Jing-Jer Lin
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    From static structures to dynamic landscapes: cryo-EM redefines RNA biology

    Shekhar Jadhav, Spandan Saha ... Marco Marcia
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

    Isaac J Fisher, Kanishka Senarath ... Angeline M Lyon
    Phospholipase Cβ3 is translocated and activated by the heterotrimeric G protein subunit Gαq at the plasma membrane, but the Gβγ heterodimer is required for maximum activation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Distal conformational steering by N-terminal pyroglutamylation enables subtype-selective GPCR activation across Aplysia PRXamide and human Neuromedin U signaling

    Jian-Hui Chang, Wei-Jia Liu ... Jian Jing
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Biochemistry and Chemical Biology

    HAX1 drives assembly and activation of the mitochondrial intermembrane space chaperone CLPB

    Monifa AV Fahie, Julia G Hoffman ... Julia R Kardon
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    Integrated respirometry and metabolomics unveil circadian metabolic dynamics in Drosophila

    Farheen Akhtar, Dania M Malik ... Aalim Weljie
    Wild-type flies anticipate daily respiratory demands by coordinating substrate use, whereas short-sleep and clock-deficient mutants shift toward reactive fuel use and altered redox metabolism.
    1. Biochemistry and Chemical Biology

    Lateral opening site of human oligopeptide transporter 2 plays a key role in the interaction with polymyxins

    Xukai Jiang, Yining Luo ... Jian Li
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Biochemistry and Chemical Biology

    Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen

    Chengxi Liu, Qinyu Jia ... Zhong-Ping Yao
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites

    Deborah Maus, Elyzana Putrianti ... Martin Blume
    Inhibiting the mitochondrial bc1-complex disrupts energy production in mature Toxoplasma gondii bradyzoites, suggesting a metabolic vulnerability in the parasite's chronic, drug-resistant stage.
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