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    1. Biochemistry and Chemical Biology

    Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen

    Chengxi Liu, Qinyu Jia ... Zhong-Ping Yao
    Not revised
    Reviewed Preprint v1
    • Important
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    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Multiple modes of cholesterol translocation in the human Smoothened receptor

    Prateek Bansal, Maia Kinnebrew ... Diwakar Shukla
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    • Solid
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMs

    Fangyuan Dong, Shan Zhang ... Shu-Heng Jiang
    Drug repurposing analyses show that citalopram exerts anti-tumor effects by targeting C5aR1 on tumor-associated macrophages to enhance phagocytosis and CD8+ T cell immunity.
    1. Biochemistry and Chemical Biology

    Aggregation-dependent epitope sequence and modification fingerprints of anti-Aβ antibodies

    Ivan Talucci, Timon Leske ... Hans Michael Maric
    Comprehensive residue-level mapping of amyloid-beta recognition reveals how sequence variants, post-translational modifications, and aggregation state shape antibody specificity, thereby guiding selection and development of therapeutic antibodies in Alzheimer’s disease.
    1. Biochemistry and Chemical Biology

    Transforming a Fragile Protein Helix into an Ultrastable Scaffold via a Hierarchical AI and Chemistry Framework

    Jun Qiu, Guojin Tang ... Peng Zheng
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    Single-step in vitro ribosome reconstitution mediated by two GTPase factors, EngA and ObgE

    Aya Sato, Weng Yu Lai ... Yoshihiro Shimizu
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Biochemistry and Chemical Biology

    Systematic characterization of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry

    Hao Jiang, Jimena Druker ... Angus I Lamond
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    Gut microbe-derived trimethylamine shapes circadian rhythms through the host receptor TAAR5

    Kala K Mahen, William J Massey ... Jonathan Mark Brown
    The gut microbe-derived metabolite trimethylamine (TMA) activates the host receptor trace amine-associated 5 (TAAR5) to instruct circadian rhythms.
    1. Biochemistry and Chemical Biology

    Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity

    Gabriel M Kline, Lisa Boinon ... R Luke Wiseman
    Establishment of AA263 analogs with improved potential for correcting pathologic disruptions of endoplasmic reticulum proteostasis implicated in the onset and pathogenesis of etiologically diverse diseases.
    1. Biochemistry and Chemical Biology

    Stall force measurement of the kinesin-3 motor KIF1A using a programmable DNA origami nanospring

    Nobumichi Takamatsu, Hiroko Furumoto ... Kumiko Hayashi
    Revised
    Reviewed Preprint v2
    Updated
    • Important
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