Browse our latest Biochemistry and Chemical Biology articles

Page 2 of 68
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Dynamics of ribosomes and release factors during translation termination in E. coli

    Sarah Adio et al.
    Translation termination is a stochastic process that utilizes loosely coupled motions of its players to complete protein synthesis and release the newly synthesized nascent chain toward its cellular destination.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

    Timothy F Miles et al.
    Numerous chemokine variants bearing no sequence resemblance elicit similar signaling behavior from the viral GPCR US28, suggesting a mechanism for receptor activation that accommodates extensive ligand degeneracy.
    1. Biochemistry and Chemical Biology

    Semisynthetic biosensors for mapping cellular concentrations of nicotinamide adenine dinucleotides

    Olivier Sallin et al.
    A family of fluorescent biosensors for nicotinamide adenine dinucleotides allows quantification of these cofactors in live cells with spatio-temporal resolution.
    1. Biochemistry and Chemical Biology

    A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells

    Sina Ibne Noor et al.
    Carbonic anhydrase II features a surface proton antenna that exclusively mediates proton exchange with monocarboxylate transporters to facilitate proton-coupled lactate transport in cancer cells.
    1. Biochemistry and Chemical Biology

    Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans

    Yue Zhou et al.
    In response to starvation, C. elegans converts a favorable pheromone that induces aggregation to an unfavorable one that induces a stress-resistant larval stage, thereby altering its chemical message without having to synthesize new pheromones de novo.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES

    Vera P Pisareva et al.
    A conformational change in the Cricket Paralysis Virus IRES upon double translocation in the ribosome uncovers an unexpected similarity with the Hepatitis C Virus IRES.
    1. Biochemistry and Chemical Biology

    Crystallographic observation of nonenzymatic RNA primer extension

    Wen Zhang et al.
    Time resolved crystal structures reveal the binding of activated monomers to the template, followed by generation of the imidazolium-bridged dinucleotide intermediate, and finally formation of a phosphodiester bond between the primer and the adjacent monomer.