Browse our latest Biochemistry and Chemical Biology articles

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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    eIF2B conformation and assembly state regulate the integrated stress response

    Michael Schoof et al.
    eIF2-P activates the integrated stress response by inducing a conformational change in eIF2B that decreases substrate (eIF2) binding and reduces eIF2B's catalytic activity.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Dynamic interactions between the RNA chaperone Hfq, small regulatory RNAs, and mRNAs in live bacterial cells

    Seongjin Park et al.
    RNA chaperone Hfq dynamically binds various pools of cellular RNAs to execute different regulatory functions.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Basis of specificity for a conserved and promiscuous chromatin remodeling protein

    Drake A Donovan et al.
    The identification of a novel mechanism of chromatin remodeling, including a conserved remodeler domain and regulatory epitopes, provides targets for the design of therapeutics to modulate transcriptional regulation in cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

    Manoj K Rathinaswamy et al.
    The c-terminus of PI3K plays a key role in regulating kinase activity, with c-terminal disease-linked mutations leading to either activation or inhibition, which reveal a path to specific inhibitors.
    1. Biochemistry and Chemical Biology

    Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins

    Víctor M Hernández-Rocamora et al.
    The synthesis of bacterial cell wall peptidoglycan was reconstituted in lipid bilayers and detected by a novel Förster resonance energy transfer real-time assay.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system

    Christopher Icke et al.
    AatD is a novel acyltransferase that mediates N-palmitoylation of glycine, a process not previously described, that results in the secretion of lipoproteins to the bacterial cell surface.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets

    Palur V Raghuvamsi et al.
    SARS-CoV-2 spike protein binding to receptor angiotensin-converting enzyme 2 allosterically enhances furin proteolysis at distal S1/S2 cleavage sites.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Phasic oxygen dynamics confounds fast choline-sensitive biosensor signals in the brain of behaving rodents

    Ricardo M Santos, Anton Sirota
    Fast fluctuations of oxygen, linked to behavioral and neural dynamics in vivo, cause phasic transients is amperometry-measured cholinergic signals via the mechanism of non-steady-state enzyme kinetics in the choline-oxidase-based biosensor.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    HP1 proteins compact DNA into mechanically and positionally stable phase separated domains

    Madeline M Keenen et al.
    Heterochromatin proteins compartmentalize DNA into compact structures resistant to mechanical disruption but susceptible to competitive dissolution.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Mitochondrial copper and phosphate transporter specificity was defined early in the evolution of eukaryotes

    Xinyu Zhu et al.
    Ancient evolutionary signatures reveal mechanistic details of substrate specificity in copper-transporting mitochondria carrier family proteins.