Browse our latest Biochemistry and Chemical Biology articles

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    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    A novel fold for acyltransferase-3 (AT3) proteins provides a framework for transmembrane acyl-group transfer

    Kahlan E Newman, Sarah N Tindall ... Marjan W Van Der Woude
    The modelled structure of a membrane protein supports the hypothesis that it has a new fold with a channel that allows a chemical group to cross the membrane to decorate surface structures.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Disrupting the ciliary gradient of active Arl3 affects rod photoreceptor nuclear migration

    Amanda M Travis, Samiya Manocha ... Jillian N Pearring
    Dominant mutations in Arl3, linked to inherited retinal dystrophy, disrupt the active Arl3-GTP ciliary gradient and cause a defect in rod photoreceptor nuclear migration that can be rescued by elevating ciliary Arl3 activity or reducing aberrant non-ciliary Arl3 activity.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth

    Luca Costantino, Stefania Ferrari ... Maria Paola Costi
    The dimer destabilizers cause a dimer-to-monomer equilibrium shift favoring the human thymidylate synthase monomer more degradable by the proteasome, thus breaking the long-standing link between inhibition and enhanced expression of the protein to fight cancer drug resistance.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction

    Jacob M Winter, Heidi L Fresenius ... Jared Rutter
    A common genomic deletion in various human cancers disrupts mitochondrial protein homeostasis in a way that might be targeted by existing drugs.
    1. Biochemistry and Chemical Biology

    Dynamic metabolome profiling uncovers potential TOR signaling genes

    Stella Reichling, Peter F Doubleday ... Duncan Holbrook-Smith
    High throughput metabolome profiling of yeast cells that are dynamically perturbed with the drug rapamycin can be used to implicate new genes in the key cellular process of TOR signaling, including the gene of unknown function CFF1.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Survival of mineral-bound peptides into the Miocene

    Beatrice Demarchi, Meaghan Mackie ... Julia Clarke
    Ostrich eggshell from the Liushu Formation in northwestern China push ancient protein preservation into the Miocene.
    1. Biochemistry and Chemical Biology

    The ‘ForensOMICS’ approach for postmortem interval estimation from human bone by integrating metabolomics, lipidomics, and proteomics

    Andrea Bonicelli, Hayley L Mickleburgh ... Noemi Procopio
    The integration of multiple omics panels obtained from bone tissue could aid in the evaluation of the postmortem interval in forensic investigations, expanding the boundaries of forensic research.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Calcium dependence of both lobes of calmodulin is involved in binding to a cytoplasmic domain of SK channels

    David B Halling, Ashley E Philpo, Richard W Aldrich
    Calcium drives interactions for both calcium-binding domains of calmodulin in complex with KCa2.1 peptides and both domains are required for normal channel function.
    1. Biochemistry and Chemical Biology

    Z-REX uncovers a bifurcation in function of Keap1 paralogs

    Alexandra Van Hall-Beauvais, Jesse R Poganik ... Yimon Aye
    Two zebrafish Keap1-paralogs are equally adept at electrophile-sensing but manifest divergent and co-regulatory electrophile-signaling behaviors.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast

    Radhika A Varier, Theodora Sideri ... Folkert J van Werven
    N6-methyladenosine (m6A) reader Pho92 is directed by Paf1C to meiotic mRNAs in an m6A-dependent and independent manner and promotes CCR4-NOT-mediated mRNA decay of m6A modified transcripts contingent on translation.