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    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites

    Deborah Maus, Elyzana Putrianti ... Martin Blume
    Revised
    Reviewed Preprint v2
    Updated
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    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the folding of PINK1 by the HSP90–CDC37 chaperone complex

    Kei Okatsu, Hayato Yamamoto ... Shuya Fukai
    Not revised
    Reviewed Preprint v1
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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

    Jennifer Kosmatka, Cong Liu ... Amy E Keating
    Not revised
    Reviewed Preprint v1
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    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Synthetic gene circuits that selectively target RAS-driven cancers

    Gabriel Valentin Senn, Leon Nissen, Yaakov Benenson
    Design and integration of various biomolecular sensors for over-activated rat sarcoma (RAS) created synthetic gene circuits that distinguish mutant versus wild-type signaling and express a therapeutic protein to kill RAS-driven cancer cells.
    1. Biochemistry and Chemical Biology

    Interrogating the structure and function of the human voltage-gated proton channel (hHv1) with a fluorescent noncanonical amino acid

    Emerson M Carmona, William N Zagotta, Sharona E Gordon
    Not revised
    Reviewed Preprint v1
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    1. Biochemistry and Chemical Biology

    Cul5Wsb2 uses BCL2 proteins as co-receptors to target Bim for degradation

    Wilhelm Vaysse-Zinkhöfer, Enya Marie Catherine Alcindor ... David Paul Toczyski
    Not revised
    Reviewed Preprint v1
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    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Determining the off-target activity of antibiotics and novel translation initiation sites in mitochondria

    James Marks, Emma Young, Markus Hafner
    Revised
    Reviewed Preprint v2
    Updated
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    • Solid
    1. Biochemistry and Chemical Biology

    Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen

    Chengxi Liu, Qinyu Jia ... Zhong-Ping Yao
    Not revised
    Reviewed Preprint v1
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    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMs

    Fangyuan Dong, Shan Zhang ... Shu-Heng Jiang
    Drug repurposing analyses show that citalopram exerts anti-tumor effects by targeting C5aR1 on tumor-associated macrophages to enhance phagocytosis and CD8+ T cell immunity.
    1. Biochemistry and Chemical Biology

    Aggregation-dependent epitope sequence and modification fingerprints of anti-Aβ antibodies

    Ivan Talucci, Timon Leske ... Hans Michael Maric
    Comprehensive residue-level mapping of amyloid-beta recognition reveals how sequence variants, post-translational modifications, and aggregation state shape antibody specificity, thereby guiding selection and development of therapeutic antibodies in Alzheimer’s disease.
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