Browse our latest Biochemistry and Chemical Biology articles

Computer simulations reveal the structural basis for a selective mechanism of ion-channel inhibition that could guide future pharmacological developments against associated human health disorders.

Structural and biochemical analyses identify a bacterial lipoprotein that associates with the outer membrane component of tripartite multi-drug efflux pumps, and its potential functional roles are explored by complementary bioinformatics, proteomcid and genetic approaches.

Genomic neighborhood signatures delineate catalytic versus putative regulatory CODH clades, establishing a framework for predicting enzyme functionality and guiding discovery of biocatalysts for CO₂ reduction.

A hierarchical framework integrating artificial intelligence with chemical principles enables the conversion of fragile α-helices into ultrastable protein scaffolds.