Structural and biochemical data suggest a mechanism for the Synaptojanin1-catalysed reaction and the role of mutations in the onset of associated neurological diseases.
Evolving E. coli NfsA for enhanced chloramphenicol detoxification in the native host environment shows that eliminating substrate competition can occur rapidly, and be key to evolving a new enzymatic function.
Applying bioorthogonal chemistry to the zebrafish/Mycobacterium marinum model of tuberculosis reveals that the virulence lipid PDIM must spread into epithelial cells in order for mycobacteria to establish infection.
Migratory birds with fuel stores composed of more omega-6 fats saved energy during long-duration flights, but this short-term energy saving came at the long-term cost of higher oxidative damage.
Structure of the Ca2+ channel Orai in an open conformation provides insights into the opening mechanism and the channel's role in regulating Ca2+ entry into immune and other non-excitable cells.
FLEXIQuant-LF provides the framework to enable large-scale identification of differentially modified peptides and quantification of their modification extent in label-free mass spectrometry data without prior knowledge of the modification type.