Browse our latest Biochemistry and Chemical Biology articles

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    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Genetic variation of putative myokine signaling is dominated by biological sex and sex hormones

    Leandro M Velez et al.
    Genetic architecture of muscle secreted protein functions are dominated by sex.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    METTL3 promotes homologous recombination repair and modulates chemotherapeutic response in breast cancer by regulating the EGF/RAD51 axis

    Enjie Li et al.
    Biochemical approaches and cellular experiments show a novel effect of METTL3 on homologous recombination repair and chemotherapeutic response via the m6A-YTHDC1-dependent regulation of the EGF/RAD51 axis.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis

    Rafael Rivera-Lugo et al.
    The bacterial pathogen Listeria monocytogenes requires respiration for the maintenance of cellular redox homeostasis.
    1. Biochemistry and Chemical Biology

    Genetic Code: Expanding codon size

    Tarana Siddika et al.
    Engineering transfer RNAs to read codons consisting of four bases requires changes in tRNA that go beyond the anticodon sequence.
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    1. Biochemistry and Chemical Biology

    Dithiothreitol causes toxicity in C. elegans by modulating the methionine–homocysteine cycle

    Gokul G, Jogender Singh
    The redox reagent dithiothreitol causes toxicity by depleting S-adenosylmethionine levels, and dietary vitamin B12 could alleviate this toxicity via the methionine synthase enzyme.
    1. Biochemistry and Chemical Biology

    SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species

    Pascal Demange et al.
    Deciphering the mechanism of action of a large family of natural and synthetic cytotoxic lipids bioactivated by enantiospecific oxidation into protein-reactive species inspires the development of enzyme-specific prodrugs.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders

    Thibaud Dieudonné et al.
    Single particle cryo-electron microscopy associated with functional studies reveal a critical role of N- and C-terminal tails in the autoinhibition of the disease-related ATP8B1-CDC50A lipid flippase, the possible role of phosphorylation in autoinhibition relief, and strong activation by PI(3,4,5)P3.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Development and characterization of new tools for detecting poly(ADP-ribose) in vitro and in vivo

    Sridevi Challa et al.
    Poly(ADP-ribose) (PAR) Trackers (PAR-Ts) are optimized PAR sensors that allow the detection and quantification of PAR levels in extracts, living cells, and living tissues with high sensitivity, and with temporal and spatial precision, in many different experimental and biological systems.
    1. Biochemistry and Chemical Biology

    Inhibitory proteins block substrate access by occupying the active site cleft of Bacillus subtilis intramembrane protease SpoIVFB

    Sandra Olenic et al.
    A novel mechanism of intramembrane protease regulation involves a protein blocking the active site of the enzyme.