Browse our latest Biochemistry and Chemical Biology articles

Structural and biochemical data suggest a mechanism for the Synaptojanin1-catalysed reaction and the role of mutations in the onset of associated neurological diseases.

A detailed molecular mechanism on lipid flipping from outside leaflet to the inside leaflet of the eukaryotic plasma membrane bilayer.

Regulation of the endoplasmic reticulum chaperone BiP by calcium.

Integral membrane subunits of energy-coupling factor transporters associate with and dissociate from each other as part of the transport mechanism.

Evolving E. coli NfsA for enhanced chloramphenicol detoxification in the native host environment shows that eliminating substrate competition can occur rapidly, and be key to evolving a new enzymatic function.

Applying bioorthogonal chemistry to the zebrafish/Mycobacterium marinum model of tuberculosis reveals that the virulence lipid PDIM must spread into epithelial cells in order for mycobacteria to establish infection.

Inter-molecular cross-seeding between phenol-soluble modulins facilitates rapid and efficient self-assembly in Staphylococcus aureus biofilms revealing a complex molecular interplay between distinct phenol-soluble modulins orchestrating functional amyloid formation.

Migratory birds with fuel stores composed of more omega-6 fats saved energy during long-duration flights, but this short-term energy saving came at the long-term cost of higher oxidative damage.

Structure of the Ca²⁺ channel Orai in an open conformation provides insights into the opening mechanism and the channel's role in regulating Ca²⁺ entry into immune and other non-excitable cells.

FLEXIQuant-LF provides the framework to enable large-scale identification of differentially modified peptides and quantification of their modification extent in label-free mass spectrometry data without prior knowledge of the modification type.