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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural elucidation of the hexameric MmpS4-MmpL4 complex from Mycobacterium tuberculosis

    Jennifer C Earp, Nicolas P Lichti ... Markus A Seeger
    Not revised
    Reviewed Preprint v1
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    1. Biochemistry and Chemical Biology

    Concatenated modular BK channel constructs reveal divergent stoichiometry in gating control by LRRC26 (γ1), pore, and selectivity filter

    Guanxing Chen, Qin Li ... Jiusheng Yan
    Regulatory stoichiometry in large-conductance potassium (BK) channels diverges by mechanism, separating single-subunit activation, graded pore contributions, and collective selectivity-filter control.
    1. Biochemistry and Chemical Biology

    Intracellular expression of a fluorogenic DNA aptamer using retron Eco2

    Mahesh A Vibhute, Corbin Machatzke ... Hannes Mutschler
    Structure-guided engineering of a bacterial retron enables intracellular production of a light-up DNA aptamer whose purified DNA retains dye-activated fluorescence, establishing retrons as a scalable route to cellular aptamer synthesis.
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    Short Report
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    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Investigating the native functions of [NiFe]-CODH through genomic context analysis

    Maximilian Böhm, Henrik Land
    Revised
    Reviewed Preprint v2
    Updated
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    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites

    Deborah Maus, Elyzana Putrianti ... Martin Blume
    Revised
    Reviewed Preprint v2
    Updated
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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the folding of PINK1 by the HSP90–CDC37 chaperone complex

    Kei Okatsu, Hayato Yamamoto ... Shuya Fukai
    Not revised
    Reviewed Preprint v1
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    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

    Jennifer Kosmatka, Cong Liu ... Amy E Keating
    Not revised
    Reviewed Preprint v1
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    • Solid
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Synthetic gene circuits that selectively target RAS-driven cancers

    Gabriel Valentin Senn, Leon Nissen, Yaakov Benenson
    Design and integration of various biomolecular sensors for over-activated rat sarcoma (RAS) created synthetic gene circuits that distinguish mutant versus wild-type signaling and express a therapeutic protein to kill RAS-driven cancer cells.
    1. Biochemistry and Chemical Biology

    Cul5Wsb2 uses BCL2 proteins as co-receptors to target Bim for degradation

    Wilhelm Vaysse-Zinkhöfer, Enya Marie Catherine Alcindor ... David Paul Toczyski
    Not revised
    Reviewed Preprint v1
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    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Determining the off-target activity of antibiotics and novel translation initiation sites in mitochondria

    James Marks, Emma Young, Markus Hafner
    Revised
    Reviewed Preprint v2
    Updated
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