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    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    USP28 deletion and small molecule inhibition destabilises c-MYC and elicits regression of squamous cell lung carcinoma

    E Josue Ruiz et al.
    1. Biochemistry and Chemical Biology

    Chaperones: Aggregation in the spotlight

    Zihao Wang et al.
    New findings clarify apparently conflicting results about how molecular agents that preserve protein integrity prevent harmful, dense aggregates from forming.
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    1. Biochemistry and Chemical Biology

    A pre-screening strategy to assess resected tumor margins by imaging cytoplasmic viscosity and hypoxia

    Hui Huang et al.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiologic states

    Simiao Xu et al.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    An improved fluorescent noncanonical amino acid for measuring conformational distributions using time-resolved transition metal ion FRET

    William N Zagotta et al.
    Time-resolved transition metal ion fluorescence resonance energy transfer using a fluorescent, noncanonical amino acid donor and metal ion acceptor measures distances and distance distributions in proteins, allowing the equilibrium distributions among conformational states to be accurately determined.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites

    Seyi Falekun et al.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    AKAP79 enables calcineurin to directly suppress protein kinase A activity

    Timothy W Church et al.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Visualizing formation of the active site in the mitochondrial ribosome

    Viswanathan Chandrasekaran et al.
    GTPBP7, NSUN4, and MTERF4 facilitate maturation of the peptidyl transferase center of the mitochondrial ribosome.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

    Michael I Barton et al.
    Common variants of the SARS-CoV-2 Spike protein and its ligand, the human ACE2 receptor, increase the binding affinity, suggesting that they could increase viral transmissibility.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions

    Charanya Kumar et al.
    Reconstitution of orientation-specific R-loop-replisome collisions with purified proteins reveals the differential impact of R-loop-associated RNA:DNA hybrids and G-quadruplexes on replication fork progression.
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