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    1. Biochemistry and Chemical Biology

    Membrane-mimetic thermal proteome profiling (MM-TPP) toward mapping membrane protein–ligand dynamic interactions

    Rupinder Singh Jandu, Ashim Bhattacharya ... Franck Duong van Hoa
    Peptidisc-based thermal proteome profiling enables detergent-free mapping of membrane protein–ligand interactions, advancing the discovery of druggable targets in membrane-mimetic environments.
    1. Biochemistry and Chemical Biology
    2. Medicine

    NAD+ boosting by oral nicotinamide mononucleotide administration regulates key metabolic and immune pathways through SIRT1 dependent and independent mechanisms to mitigate diet-induced obesity and dyslipidemia in mice

    Yasser Majeed, Najeeb M Halabi ... Nayef A Mazloum
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology

    Integrated Respirometry and Metabolomics Unveil Circadian Metabolic Dynamics in Drosophila

    Farheen Akhtar, Dania Malik ... Aalim M Weljie
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method

    Soumajit Dutta, Diwakar Shukla
    New psychoactive substances activate cannabinoid receptors using distinct ligand-receptor interactions.
    1. Biochemistry and Chemical Biology

    Insight into the bioactivity and action mode of betulin, a candidate aphicide from plant metabolite, against aphids

    Junxiu Wang, Matthana Klakong ... Hong Zhou
    The insecticidal activity of betulin, a plant-derived metabolite, against the peach aphid depends on specific targeting and inhibition of MpGABR.
    1. Biochemistry and Chemical Biology

    Engineering NIR-sighted bacteria

    Stefanie SM Meier, Michael Hörzing ... Andreas Möglich
    Custom-tailored bathy-phytochromes control bacterial gene expression by near-infrared light while exhibiting minimal response to red light, thus unlocking innovative application scenarios.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Structure-based Design of Chimeric Influenza Hemagglutinins to Elicit Cross-group Immunity

    Karla M Castro, Reyhaneh Ayardulabi ... Bruno E Correia
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Pleomorphic effects of three small-molecule inhibitors on transcription elongation by Mycobacterium tuberculosis RNA polymerase

    Omar Herrera-Asmat, Alexander B Tong ... Carlos Bustamante
    Optical tweezers are used to gain mechanistic insight in the mechanism of inhibition of three distinct compounds being developed as antibiotics against Mycobacterium tuberculosis.
    1. Biochemistry and Chemical Biology

    Brown adipose tissue and skeletal muscle coordinately contribute to thermogenesis in mice

    Yuna Izumi-Mishima, Rie Tsutsumi ... Hiroshi Sakaue
    Muscle-derived branched-chain amino acids support thermogenesis in brown adipose tissue, thereby helping maintain body temperature during impaired muscle function or physiological stress.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    A recursive pathway for isoleucine biosynthesis arises from enzyme promiscuity

    Vittorio Rainaldi, Stefano Donati ... Nico J Claassens
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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