Browse our latest Biochemistry and Chemical Biology articles

This enzymatic method enables highly specific and complete 1:1 protein conjugations with small molecules, solid supports, and other proteins, offering broad applicability across diverse biochemical and biotechnological applications.

The central nitrogen-metabolite 2-oxoglutarate directly promotes glutamine synthetase activity by inducing its dodecameric assembly and priming the active sites, representing a novel mechanism of regulation.

A camelid single-domain antibody potently and specifically inhibits pyruvate kinases from trypanosomatids.

CROWN-seq provides the first precise and quantitative map of N⁶,2’-O-dimethyladenosine (m⁶Am) in mRNA and snRNA, revealing the link between m⁶Am modification and efficient transcription, rather than translation and RNA stability.

Structure-based approach identifies a K_ATP-binding compound that has the potential of normalizing insulin secretion in congenital hyperinsulinism by correcting defective K_ATP channel trafficking to the cell surface.

The microenvironment within biomolecular condensates exhibits interfacial behaviors characterized by a combination of hydrophobic and hydrophilic properties.

Targeting two novel sites on the hepatitis B virus capsid disrupts its assembly and induces aggregation, suggesting potential for antiviral therapy development.