Biochemical and genetic evidence identifies ATP5I as a biguanide target, redefining biguanide action through ATP synthase regulation and assembly, mitochondrial architecture, and mitochondrial protein turnover.
Soenke Cordeiro, Robert Patejdl ... Marianne A Musinszki
Identification of mangostins as potent BK channel activators links natural xanthones to vascular smooth muscle relaxation, providing a mechanistic basis for their reported antihypertensive effects.
Resolving the mechanism of RXR ligand-dependent NR4A-RXR nuclear receptor heterodimer activation requires a diverse ligand set that includes heterodimer-selective agonists.
Emerson M Carmona, William N Zagotta, Sharona E Gordon
A fluorescent noncanonical amino acid enables structural measurements across full-length human voltage-gated proton channel (Hv1) and reveals zinc-dependent conformational changes.
Computer simulations reveal the structural basis for a selective mechanism of ion-channel inhibition that could guide future pharmacological developments against associated human health disorders.
Structural and biochemical analyses identify a bacterial lipoprotein that associates with the outer membrane component of tripartite multi-drug efflux pumps, and its potential functional roles are explored by complementary bioinformatics, proteomcid and genetic approaches.
