Browse our latest Biochemistry and Chemical Biology articles

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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

    Roman O Fedoryshchak, Karim El-Bouri ... Richard Treisman
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A conformational fingerprint for amyloidogenic light chains

    Cristina Paissoni, Sarita Puri ... Carlo Camilloni
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    The chromokinesin Kid (KIF22) forms a homodimer, moves processively along microtubules and transports double-strand DNA

    Shinsuke Niwa, Natsuki Furusaki ... Kyoko Chiba
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Disordered proteins interact with the chemical environment to tune their protective function during drying

    Shraddha KC, Kenny H Nguyen ... Thomas C Boothby
    The ability of intrinsically disordered proteins to protect sensitive enzymes during drying can be tuned through interactions with cosolutes.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Introduction of cytosine-5 DNA methylation sensitizes cells to oxidative damage

    Joanna Krwawicz, Caroline J Sheeba ... Peter Sarkies
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8

    Amrita Rai, Petra Janning ... Roger S Goody
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins

    Kawaguchi Shinichi, Xu Xin ... Kai Toshie
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

    Raji E Joseph, Thomas E Wales ... Amy H Andreotti
    Revised
    Reviewed Preprint v2
    Updated
    1. Biochemistry and Chemical Biology

    Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785

    Shan Zhang, Robyn Stix ... José D Faraldo-Gómez
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Isobaric crosslinking mass spectrometry technology for studying conformational and structural changes in proteins and complexes

    Jie Luo, Jeff Ranish
    A novel pair of isobaric crosslinking reagents is described, which allow relative quantification of crosslinker-modified peptides during mass spectrometry analysis for comparative structural studies of proteins and protein complexes.
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