Browse our latest Biochemistry and Chemical Biology articles

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    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Enrichment of rare codons at 5' ends of genes is a spandrel caused by evolutionary sequence turnover and does not improve translation

    Richard Sejour, Janet Leatherwood ... Bruce Futcher
    The 5' ends of genes are slightly enriched for rare codons largely because the ends turnover in evolution and gather rare codons, and these rare codons do not improve translation.
    1. Biochemistry and Chemical Biology

    Uncovering the BIN1-SH3 interactome underpinning centronuclear myopathy

    Boglarka Zambo, Evelina Edelweiss ... Gergo Gogl
    The SH3 domain of BIN1 mediates an unexpectedly large array of interactions, which is perturbed by missense variants.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Human DDX6 regulates translation and decay of inefficiently translated mRNAs

    Ramona Weber, Chung-Te Chang
    DDX6 triggers inefficiently translated mRNA decay by interacting with the ribosome through its FDF motif via the 5'-3' mRNA decay pathway.
    1. Biochemistry and Chemical Biology

    A synthetic method to assay polycystin channel biophysics

    Megan Larmore, Orhi Esarte Palomero ... Paul G DeCaen
    1. Biochemistry and Chemical Biology

    Intracellular Expression of a Fluorogenic DNA Aptamer Using Retron Eco2

    Mahesh A Vibhute, Corbin Machatzke ... Hannes Mutschler
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics
    3. Cell Biology
    Plasma membrane going around a banner with two different kinases and one affecting the nucleus/cell cycle. Phosphates are dotted in the background

    Special Issue: Allosteric Regulation of Kinase Activity

    Edited by Volker Dötsch et al.
    Our latest Special Issue brings together research on the allosteric regulation of kinase activity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Special Issue: Allosteric regulation of kinase activity

    Amy H Andreotti, Volker Dötsch
    The articles in this special issue highlight how modern cellular, biochemical, biophysical and computational techniques are allowing deeper and more detailed studies of allosteric kinase regulation.
    Editorial
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    1. Biochemistry and Chemical Biology

    E. coli ClpB is a Robust and Processive Protein Unfoldase

    Jaskamaljot Kaur Banwait, Liana Islam, Aaron L Lucius