Browse our latest Biochemistry and Chemical Biology articles

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    1. Biochemistry and Chemical Biology

    Stall force measurement of the kinesin-3 motor KIF1A using a programmable DNA origami nanospring

    Nobumichi Takamatsu, Hiroko Furumoto ... Kumiko Hayashi
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites

    Steven P Maher, Malina A Bakowski ... Dennis E Kyle
    Drug repurposing screens reveal several epigenetic inhibitors as active against P. vivax hypnozoites demonstrating that epigenetic pathways play a central role in hypnozoite quiescence.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Synthetic gene circuits that selectively target RAS-driven cancers

    Gabriel Senn, Leon Nissen, Yaakov Benenson
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    MORC2 Mediates Transcriptional Regulation Through Liquid-Liquid Phase Separation and DNA Binding

    Yanshen Zhang, Weiya Xu ... Yihui Bi
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Biochemistry and Chemical Biology

    D-serine suppresses one-carbon metabolism by competing with mitochondrial L-serine transport

    Masataka Suzuki, Kenichiro Adachi ... Jumpei Sasabe
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Biochemistry and Chemical Biology

    Blue-shifted ancyromonad channelrhodopsins for multiplex optogenetics

    Elena G Govorunova, Oleg A Sineshchekov ... John L Spudich
    Ancyromonad channelrhodopsins advance understanding of ionic selectivity and wavelength regulation in light-gated ion channels, and expand the toolkit for multiplexing with red-shifted fluorescent sensors.
    1. Biochemistry and Chemical Biology

    Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response

    CJ San Felipe, Jyoti Batra ... James S Fraser
    Lipid binding stabilizes the SARS-CoV-2 Orf9b homodimer, slowing its conversion to the Tom70-binding monomeric form and modulating interferon suppression.
    1. Biochemistry and Chemical Biology

    The TTLL10 polyglycylase is stimulated by tubulin glutamylation and inhibited by polyglycylation

    Steven W Cummings, Yan Li ... Antonina Roll-Mecak
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    • Compelling