Browse our latest Biochemistry and Chemical Biology articles

Distinct surfaces of an interbacterial competition cell wall toxin mediate interactions with different cellular binding partners, resulting in an inherent evolutionary trade-off across the toxin superfamily.

Determination of a model of mitochondrial protein import elucidated using a high-resolution transport assay and kinetic modelling.

Fluorescently-tagged profilin-1 behaves similar to the tag-free protein in biochemical and cell-based assays.

The human eye lens imports and concentrates within itself a naturally abundant small molecule that inhibits cataract-associated aggregation of an eye lens protein before the aggregates get large enough to scatter light.

Hypertrophic cardiomyopathy-causing mutations in the light chain-binding region of β-cardiac myosin's lever arm appear to disrupt myosin tail-based autoinhibition, while mutations in the pliant region of the lever arm reduce autoinhibition in the presence of actin and impact myosin’s powerstroke.

The cryo-EM structural and functional analyses reveals the lactate dehydrogenase/electron-transferring flavoprotein (Ldh-EtfAB) in its enzymatically active form and the geometry of the confurcating flow of two energetically spitted electrons via 2 FAD and 1 [4Fe-4S] cluster to a central FAD.

Activin class member, activin C, is a canonical TGFβ family member that signals through the type I receptor, action receptor-like kinase 7 and is resistant to follistatin antagonism.

The integration of experimental and data mining approaches provides novel insights into deubiquitinating enzymes individually and as a gene family.

The first recently discovered inhibitors of lysine biosynthesis with in planta activity have a dual-target mode of action, which provides proof-of-concept for the development of multi-target ‘resistance-resistant’ herbicides with a novel mode of action.

PLC-γ isozymes are activated by a combination of receptor engagement and membrane proximity.