A cross-talk is revealed between two branches of metabolisms, amino acid limitation suppressing fatty acid biosynthesis, via posttranslational modifications of an enzyme involved in fatty acid biosynthesis.
Nelson García-Vázquez, Tania J González-Robles ... Michele Pagano
Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.
The thickness of the periplasmic region is reduced in strains of pneumococcus that are deleted in genes responsible for the incorporation of teichoic acid in the cell envelope.
Kinetic measurements of kinesin-1's front and rear heads reveal how different neck linker orientation regulate their activity, enabling the motor protein to move in a coordinated manner along microtubules.
A Sofia F Oliveira, Fiona L Kearns ... Adrian J Mulholland
Equilibrium and nonequilibrium simulations uncover how the fatty acid site in the SARS-CoV-2 spike modulates protein dynamics, revealing its intricate allosteric connections and the impact of glycans on these networks.
Conor J Howard, Nathan S Abell ... Nathan B Lubock
Mapping the functional landscape of >6600 MC4R variants via deep mutational scanning reveals novel determinants of biased signaling and ligand interactions that inform targeted obesity therapeutics.
