Browse our latest Biochemistry and Chemical Biology articles

Page 6 of 171
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    eIF3 engages with 3’-UTR termini of highly translated mRNAs

    Santi Mestre-Fos, Lucas Ferguson ... Jamie HD Cate
    The extent of human eukaryotic translation initiation factor eIF3 interaction with the 3' ends of mRNA 3' untranslated regions (3'-UTRs) correlates with the level of translation.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species

    Man Zhu, Meng Ma ... Jing Yang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control

    Mykola Roiuk, Marilena Neff, Aurelio A Teleman
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    Membrane mimetic thermal proteome profiling (MM-TPP) towards mapping membrane protein-ligand dynamics

    Rupinder Singh Jandu, Mohammed Al-Seragi ... Franck Duong van Hoa
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Yerba mate (Ilex paraguariensis) genome provides new insights into convergent evolution of caffeine biosynthesis

    Federico A Vignale, Andrea Hernandez Garcia ... Adrian G Turjanski
    DNA sequencing of the yerba mate (Ilex paraguariensis) genome reveals convergent genomic changes, biochemical pathways, mutations, and substrate-binding orientations responsible for caffeine biosynthesis when compared to coffee and tea plants.
    1. Biochemistry and Chemical Biology

    Elevated Ubiquitin Phosphorylation by PINK1 Contributes to Proteasomal Impairment and Promotes Neurodegeneration

    Cong Chen, Tong-Yao Gao ... Wei-Ping Zhang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease

    Angel D'Oliviera, Xuhang Dai ... Jeffrey S Mugridge
    The SARS-CoV-2 main protease specifically cleaves a conserved sequence in the human tRNA modifying enzyme TRMT1, resulting in reduced tRNA binding and the complete loss of TRMT1-mediated tRNA methyltransferase activity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    p53 engagement is a hallmark of an unfolded protein response in the nucleus of mammalian cells

    Joseph H Park, Thomas J Wandless
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes

    Upasana L Mallimadugula, Matthew A Cruz ... Gregory R Bowman
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology

    A green lifetime biosensor for calcium that remains bright over its full dynamic range

    Franka H van der Linden, Stephen C Thornquist ... Joachim Goedhart
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
Newer articles Older articles