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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into the recruitment of viral Type 2 IRES to ribosomal preinitiation complex for protein synthesis

    Deepakash Das, Tanweer Hussain
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Multiple modes of cholesterol translocation in the human Smoothened receptor

    Prateek D Bansal, Maia Kinnebrew ... Diwakar Shukla
    Not revised
    Reviewed Preprint v1
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    1. Biochemistry and Chemical Biology

    Systematic characterization of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry

    Hao Jiang, Jimena Druker ... Angus I Lamond
    Not revised
    Reviewed Preprint v1
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    • Solid
    1. Biochemistry and Chemical Biology

    Dynamic assembly of malate dehydrogenase-citrate synthase multienzyme complex in the mitochondria

    Joy Omini, Inga Krassovskaya ... Toshihiro Obata
    Not revised
    Reviewed Preprint v1
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    • Incomplete
    1. Biochemistry and Chemical Biology

    Action mechanism of a novel agrichemical quinofumelin against Fusarium graminearum

    Qian Xiu, Xiaoru Yin ... Yabing Duan
    The target of quinofumelin is DHODH in the de novo pyrimidine biosynthesis pathway.
    1. Biochemistry and Chemical Biology

    Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes

    Janelle JY Chuah, Madalena R Daugherty, David M Smith
    A single hydrophobic interaction drives allosteric gate-opening of the archaeal 20S proteasome, identifying a specific new target for therapeutic drug design.
    1. Biochemistry and Chemical Biology

    Phage-displayed synthetic library and screening platform for nanobody discovery

    Baolong Xia, Ah-Ram Kim ... Norbert Perrimon
    A phage-displayed synthetic library and screening platform offer a streamlined, cost-effective solution for nanobody discovery.
    1. Biochemistry and Chemical Biology

    Concatenated Modular BK Channel Constructs Reveal Divergent Stoichiometry in Gating Control by LRRC26 (γ1), Pore, and Selectivity Filter

    Guanxing Chen, Qin Li, Jiusheng Yan
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology

    Elevated ubiquitin phosphorylation by PINK1 contributes to proteasomal impairment and promotes neurodegeneration

    Cong Chen, Tong-Yao Gao ... Wei-Ping Zhang
    Elevated ubiquitin phosphorylation disrupts proteasomal function, creating a self-amplifying cycle that drives progressive protein aggregation and neuronal injury across multiple neurodegenerative conditions.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Superoxide Dismutases maintain niche homeostasis in stem cell populations

    Olivia Majhi, Aishwarya Chhatre ... Devanjan Sinha
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    • Incomplete
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