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    1. Biochemistry and Chemical Biology

    DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids

    Emily L Dearlove, Chatrin Chatrin ... Danny T Huang
    Biochemical and structural analyses reveal direct ubiquitin modification of single-stranded nucleic acids, catalysed by the DTX3L ubiquitin ligase.
    1. Biochemistry and Chemical Biology

    Single turnover transient state kinetics reveals processive protein unfolding catalyzed by Escherichia coli ClpB

    Jaskamaljot Kaur Banwait, Liana Islam, Aaron L Lucius
    Development of sequential mixing, single turnover stopped-flow approach reveals processive protein unfolding catalyzed by Escherichia coli ClpB.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Dynamic basis of lipopolysaccharide export by LptB2FGC

    Marina Dajka, Tobias Rath ... Benesh Joseph
    LptC regulates the LPS entry gate in LptB2FG, likely through a dynamic behavior of its transmembrane helix, while the β-jellyroll domains are tethered in the periplasm.
    1. Biochemistry and Chemical Biology

    The intrinsically disordered N-terminus of SUMO1 is an intramolecular inhibitor of SUMO1 interactions

    Sebastian M Richter, Fan Jin ... Frauke Melchior
    Revised
    Reviewed Preprint v2
    Updated
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

    Siying Zeng, Yuqi Wang ... Xun Hu
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    The deubiquitinase Ubp3/Usp10 constrains glucose-mediated mitochondrial repression via phosphate budgeting

    Vineeth Vengayil, Shreyas Niphadkar ... Sunil Laxman
    A primary constraint for mitochondrial repression is access to cytosolic inorganic phosphate, which is determined by the glycolytic flux rate.
    1. Biochemistry and Chemical Biology

    Stabilization of GTSE1 by cyclin D1-CDK4/6 promotes cell proliferation: relevance in cancer prognosis

    Nelson García-Vázquez, Tania J González-Robles ... Sharon Kaisari
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Immunotherapy: The power lies in the glycans

    Luca Unione, Jesús Jiménez-Barbero
    Glycans play an important role in modulating the interactions between natural killer cells and antibodies to fight pathogens and harmful cells.
    Version of Record
    Insight
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins

    Kristina Ehring, Sophia Friederike Ehlers ... Kay Grobe
    A composite hedgehog release model that incorporates and supports a previously disparate set of observations has been presented.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Point of View: Teaching troubleshooting skills to graduate students

    Gina Partipilo, Yang Gao ... Benjamin K Keitz
    Pipettes and Problem Solving is an initiative that teaches some of the skills needed to figure out why an experiment is producing unexpected results.
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