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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers

    Xiaoyu Yu, Yuanjun He ... Douglas J Kojetin
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology

    Crystal structure and catalytic mechanism of PL35 family glycosaminoglycan lyases with an ultrabroad substrate spectrum

    Lin Wei, Hai-Yan Cao ... Fuchuan Li
    The determination of GAGases structure facilitates the elucidation of the catalytic mechanism of PL35 family lyases and provides potential evidence for the hypothesis that GAG lyase evolved from alginate lyase.
    1. Biochemistry and Chemical Biology

    Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

    Yasuhiro Shinkai, Yunjie Ding ... Yoshito Kumagai
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies

    Ivan Talucci, Timon Leske ... Hans-Michael Maric
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    The alternative oxidase reconfigures the larval mitochondrial electron transport system to accelerate growth and development in Drosophila melanogaster

    Geovana S Garcia, Murilo F Othonicar ... Marcos T Oliveira
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Identification and classification of ion-channels across the tree of life: Insights into understudied CALHM channels

    Rahil Taujale, Sung Jin Park ... Natarajan Kannan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    • Inadequate
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy

    Liudmyla Arifova, Brian S MacTavish ... Douglas J Kojetin
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress

    Rezwana Karim, Wendi Teng ... Hening Lin
    A cross-talk is revealed between two branches of metabolisms, amino acid limitation suppressing fatty acid biosynthesis, via posttranslational modifications of an enzyme involved in fatty acid biosynthesis.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during microglial activation

    Benoit Arnould, Adeline Martz ... Thomas Grutter
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosis

    Nelson García-Vázquez, Tania J González-Robles ... Michele Pagano
    Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.
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