Maria Maldonado, Abhilash Padavannil ... James A Letts
The first atomic resolution structure of a mitochondrial respiratory complex from plants provides insight into the assembly and evolution of respiration in autotrophic eukaryotes.
In order to enter a cell, an ammonium ion must first dissociate to form an ammonia molecule and a hydrogen ion (a proton), which then pass through the cell membrane separately and recombine inside.
Cryo-EM structures of human MCU-EMRE-MICU1-MICU2 complex in the apo and Ca2+-bound states reveal how MICU1 and MICU2 impart their gating function to the mitochondrial calcium uniporter.
Protein stability in the cage formed by the chaperonin GroEL and its cofactor GroES is reduced by more than 5 kcal mol-1 relative to that in bulk solution.
NMR and biochemical analysis reveal new insights into how the critical protein kinase Akt is regulated by phosphorylation and is inhibited by an experimental therapeutic.
Chongyuan Wang, Agata Jacewicz ... Stephen Barstow Long
Cryo-EM structures reveal that MICU1-MICU2 operates like a regulatable toxin to block the pore of the mitochondrial calcium uniporter and confer Ca2+-dependent control.
Sandy Mattijssen, James R Iben ... Richard J Maraia
LARP4 protects mRNAs against deadenylation over a wide range of poly(A) lengths but with most apparent functional impact on short lengths known to sensitize PABP binding and mRNA stability.
Tn5 transposase has direct tagmentation activity towards RNA/DNA hybrids, which is harnessed as a more convenient and faster RNA-seq library construction method and will benefit RNA and chromatin research.
