Browse our latest Biochemistry and Chemical Biology articles

Hybrid-type fluorescent ATP sensor showing submicromolar affinity, a large fluorescence response, high selectivity and pH-independence visualized extracellular ATP dynamics in the brain of living mice with high spatiotemporal resolution.

The mechanism of Dbf4-dependent kinase (DDK) recruitment to replication origins and its regulation by the checkpoint have been identified.

The major cytosolic yeast peroxiredoxin Tsa1 controls aging and H₂O₂-resistance by inhibiting protein kinase A through a conserved cysteine in the catalytic subunit activation loop and not by scavenging H₂O₂.

A nightshade family gene cluster creates phenotypic novelty in trichome defensive metabolites via evolution of lipid metabolic enzymes.

Specific and non-specific conformational confinement, via point mutation or cochaperone interaction or macro-molecular crowding, stimulates protein function in Hsp90 by reducing non-productive conformational flexibility.

The role of LIS1 in dynein-mediated transport in various biological contexts is reviewed with a focus on recent studies that revealed a new mechanism by which LIS1 functions.

As worms age reduced glutathione together with increased ferrous iron increases frailty and leads to ferroptosis, which is amenable to therapeutic intervention.

In an in vitro RNA replication system, an RNA spontaneously diversifies and continuously evolves through coevolution with parasitic entities.

A widespread ribonuclease is a CRISPR-associated ring nuclease with a highly unusual cooperative mechanism involving tetramerisation of the enzyme.

Two components of the inner kinetochore (OA and Mif2) are independently capable of transmitting physiologically relevant forces to a centromeric nucleosome.