Browse our latest Cancer Biology articles

Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

A piece of first-surface mirror for side-view observation enables non-destructive in situ monitoring of structural changes of 3D tumor spheroids during the formation, migration, and fusion process.

NPRL2 gene therapy induces robust antitumor immunity and overcome anti-PD1 resistance through augmenting antigen-presentation and cytotoxic T cells activation in KRAS/STK11 mutant NSCLC in humanized mouse model.

Combined Inhibition of DNA replication and repair synergistically prevents tumor growth, representing a promising strategy for cancer therapy.

BCR profiling of tumor infiltrating B cells alongside with circulating and lymph node-resident B cells deepens understanding of their unique properties.

Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.

Telomere-sensitive regulation of IL1R1 by the shelterin protein TERF2 modulates tumour macrophage inflitration in triple-negative breast cancer.

The TIPE/PKM2/HIF-1α signaling pathway plays a crucial role in enhancing cancer stem cell properties by facilitating glycolysis, thereby presenting a promising therapeutic target for melanoma intervention.

Chemotherapy remodels lung adenocarcinoma’s tumor microenvironment by driving metabolic reprogramming and shifting immune cell functions to modulate tumor progression and immune responses.

The novel PDLIM2 nanomedicine enhances chemoimmunotherapy for complete cure of lung cancer.