Overexpression of inhibitor of Bruton's tyrosine kinase contributes to the process of tumorigenesis by amplifying translation, represents a promising target for anti-cancer therapies.
Equivalence testing and Bayes factors are informative statistical methods for analyzing replication studies of original studies with null results, and can address the limitations of the commonly used non-significance criterion.
A genetic variant within a newly identified enhancer regulates the expression of a key pharmacogene and alters the balance between resistance and sensitivity to a widely used chemotherapeutic.
Older PhenoAge was consistently related to an increased risk of incident cancer with adjustment for chronological age and the aging process could be retarded by adherence to a healthy lifestyle.
Timothy J Walker, Eduardo Reyes-Alvarez ... Lois M Mulligan
TMEM127 depletion alters membrane dynamics, promoting cell surface accumulation and constitutive activity of growth factor receptors, and ultimately providing a novel paradigm for oncogenesis through aberrant receptor localization and signaling.
Gregory Caleb Howard, Jing Wang ... William P Tansey
Analysis of the action of WDR5 inhibitors in leukemia cells reveals decreased ribosome inventory, impaired protein synthesis, induction of nucleolar stress, and activation of p53 via alternative splicing of MDM4.
