Browse our latest Cancer Biology articles

Glycolysis and attenuates oxidative phosphorylation through long-chain fatty acids, while mitochondrial biogenesis and anabolism remain intact, to accelerate the progression of acute megakaryocytic leukemia.

A novel, non-invasive strategy combining radiomics and blood extracellular vesicle-derived microRNA profiling to sharpen pancreatic cancer diagnosis is introduced.

Abundant single-stranded telomeric DNA distinguishes alternative lengthening of telomeres-positive cells and represents a potential biomarker and therapeutic vulnerability.

The promotion of C1QBP accumulation by PA28γ leads to the malignant progression of tumor by affecting mitochondrial function, which could be a launch pad for therapeutic intervention of tumor development.

Uncovering a novel PDE1A/YTHDF2/STAT3 pathway in non-small cell lung cancer (NSCLC) progression also provides therapeutic strategies for treating NSCLC patients with metastasis.

SiNETs separate into two subtypes, both with low proliferation of neuroendocrine cells and higher proliferation of other cells.

A human pluripotent stem cell-based model demonstrates how TP53/RB1 loss and MYC overexpression drive aggressive, neuroendocrine small cell lung cancer progression and metastasis, enabling investigation of tumor heterogeneity and therapeutic response in a defined genetic context.

Disruption of vimentin–actin interaction induces XIST expression and drives epithelial-to-mesenchymal transition and stem cell-like traits in breast cancer cells, enhancing oncogenic behaviour in nude mice independent of oestrogen.

The N-terminally truncated Δ133p53α and Δ160p53α isoforms exert dominant-negative effects through co-aggregation with p53, disrupting its transcriptional activity and cellular distribution, thereby contributing to cancer development.