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    1. Cancer Biology

    ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1

    Jordina Rincon-Torroella, Marco Dal Molin ... Surojit Sur
    Monocarboxylate transporter 1 overexpressed pancreatic cancers can be therapeutically targeted with ME3BP-7, a promising new agent with unique mode of action.
    1. Computational and Systems Biology
    2. Cancer Biology

    Single-Cell Atlas of AML Reveals Age-Related Gene Regulatory Networks in t(8;21) AML

    Jessica Whittle, Stefan Meyer ... Mudassar Iqbal
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Computational and Systems Biology
    2. Cancer Biology

    Drug combination prediction for cancer treatment using disease-specific drug response profiles and single-cell transcriptional signatures

    Daniel Osorio, Parastoo Shahrouzi ... Marieke L Kuijjer
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Cancer Biology
    2. Genetics and Genomics

    Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer

    Arkajyoti Bhattacharya, Thijs S Stutvoet ... Rudolf SN Fehrmann
    Independent component analysis of ovarian cancer transcriptomes reveals distinct transcriptional patterns associated with overall survival.
    1. Cancer Biology

    Causal associations between plasma proteins and prostate cancer: a Proteome-Wide Mendelian Randomization

    Chen Lin, Rong Zhuona ... Pang Xiaocong
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology
    2. Cancer Biology

    Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics

    David Papadopoli, Ranveer Palia ... Ivan Topisirovic
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cancer Biology
    2. Developmental Biology

    VGLL2 and TEAD1 fusion proteins identified in human sarcoma drive YAP/TAZ-independent tumorigenesis by engaging EP300

    Susu Guo, Xiaodi Hu ... Junhao Mao
    Characterization of recurrent fusion proteins in rhabdomyosarcoma identified a Hippo pathway-independent mechanism involving VGLL2 and TEAD1 driving oncogenic transformation.
    1. Cancer Biology

    Repression of the Wnt pathway effector TCF7L2 reverses lethal cachexia in mice with intestinal cancers

    Mei Ling Leong, Christiane Ruedl, Klaus Karjalainen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cancer Biology

    The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells

    Jie Fang, Shivendra Singh ... Jun Yang
    Drastic differences in genetic and epigenetic fitness of MYC-driven cancer cells in 3D vs 2D culture.
    Version of Record
    Research Article
    • Important
    • Convincing
    • Incomplete
    1. Cell Biology
    2. Cancer Biology

    Human RAP2A Homolog of the Drosophila Asymmetric Cell Division Regulator Rap2l Targets the Stemness of Glioblastoma Stem Cells

    Maribel Franco, Ricardo Gargini ... Ana Carmena
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
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