Browse our latest Cancer Biology articles

Restitution of RAP2A, human homolog of Drosophila asymmetric cell division regulator Rap2l, in glioblastoma neurosphere cultures targets the stemness of glioblastoma stem cells and could contribute to reduce glioblastoma expansion.

The identification of 20 causal plasma proteins for prostate cancer represents a critical step toward addressing the need for improved diagnostic specificity and reveals promising new targets for therapeutic intervention.

Chromosome compartment analysis of a cancer cell line cohort reveals different subsets of compartment changes where some track epithelial to mesenchymal transition while others reflect secondary metastatic organ-specific reorganizations.

Pharmacological disruption of TopBP1 condensation impairs ATR signaling, promotes DNA damage and apoptosis, and enhances the efficacy of FOLFIRI chemotherapy in colorectal cancer.

A unique pathogenic mutation on the primary prolyl hydroxylase of the oxygen-sensing pathway compromises the capacity to hydroxylate the hypoxia-inducible factor's N-terminal oxygen-dependent degradation domain proline while retaining activity against the otherwise catalytically predominant C-terminal proline.