Browse our latest Cancer Biology articles

Uncovering a novel PDE1A/YTHDF2/STAT3 pathway in non-small cell lung cancer (NSCLC) progression also provides therapeutic strategies for treating NSCLC patients with metastasis.

SiNETs separate into two subtypes, both with low proliferation of neuroendocrine cells and higher proliferation of other cells.

A human pluripotent stem cell-based model demonstrates how TP53/RB1 loss and MYC overexpression drive aggressive, neuroendocrine small cell lung cancer progression and metastasis, enabling investigation of tumor heterogeneity and therapeutic response in a defined genetic context.

Disruption of vimentin–actin interaction induces XIST expression and drives epithelial-to-mesenchymal transition and stem cell-like traits in breast cancer cells, enhancing oncogenic behaviour in nude mice independent of oestrogen.

The N-terminally truncated Δ133p53α and Δ160p53α isoforms exert dominant-negative effects through co-aggregation with p53, disrupting its transcriptional activity and cellular distribution, thereby contributing to cancer development.

S100a4⁺ alveolar macrophages facilitate angiogenesis through CPT1A-PPAR-γ-mediated fatty acid metabolism, thereby triggering atypical adenomatous hyperplasia.

Patients with microsatellite stable/low microsatellite instability mismatch repair-proficient metastatic colorectal cancer may be sensitive to tislelizumab treatment after receiving Gamma Knife stereotactic radiotherapy.

Experiments with tools designed to detect DNA damage reveal unique and conserved features of telomeres in cancer cells.